Basic Description

Product Name	Recombinant SMARCD1 Antibody - Primary antibody, specific to SMARCD1, Rabbit IgG
Synonyms	60 kDa BRG-1/Brm-associated factor subunit A antibody \| 60 kDa BRG1/Brm associated factor subunit A antibody \| BAF60A antibody \| BRG1 associated factor 60Aantibody \| BRG1-associated factor 60A antibody \| Chromatin remodeling complex BAF60A subunitantibody
Specifications & Purity	ExactAb™, Validated, Recombinant, 0.6 mg/mL
Host species	Rabbit
Specificity	SMARCD1
Immunogen	A synthetic peptide derived from human SMARCD (AA 1-15)
Positive Control	WB: HeLa, A549, U2OS, Jurkat, HEK293 and NIIH/3T3 cell lysates.
Conjugation	Unconjugated
Grade	ExactAb™, Recombinant, Validated
Product Description	Rabbit anti Human SMARCD1 Antibody, Recombinant, could be used for WB and so on. Application: WB: 1/500-1/1000 Protein Function Involved in chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Has a strong influence on the Vitamin D-mediated transcriptional activity from an enhancer Vitamin D receptor element (VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor (VDR) heterodimer. Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.

Product Properties

Isotype	Rabbit IgG
SDS-PAGE	150 kDa
Purification Method	Antigen affinity purified
Form	Liquid
Concentration	0.6 mg/mL
Storage Temp	Store at -20°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Images

Recombinant SMARCD1 Antibody (Ab128279) - Western Blot
All lanes: Recombinant SMARCD1 Antibody (Ab128279) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 58 kDa
Observed band size: 58 kDa
Exposure time: 5.0 s

Associated Targets(Human)

SMARCD1 Tbio SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (0 Activities)

Discover Target: SMARCD1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Application

Application	Dilution info
WB	1/500-1/1000

Certificates

Certificate of Analysis(COA)

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2 results found

Lot Number	Certificate Type	Date	Item
ZJ24F0303521	Certificate of Analysis	Mar 22, 2024	Ab128279
ZJ24F0303520	Certificate of Analysis	Mar 22, 2024	Ab128279

FAQs and Articles

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SKU	Size	Availability	Price
Ab128279-10μl	10μl	In stock	$69.90
Ab128279-50μl	50μl	In stock	$189.90
Ab128279-100μl	100μl	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$299.90
Ab128279-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,699.90

Recombinant SMARCD1 Antibody - Primary antibody, specific to SMARCD1, Rabbit IgG