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Recombinant TNF Receptor II Antibody - Primary antibody, specific to TNF Receptor II, Rabbit IgG

    Application:
  • WB
Features and benefitsView More
  • Host species: Rabbit
  • Species reactivity(Reacts with): Human,Mouse,Rat
  • Isotype: Rabbit IgG
  • Conjugation: Unconjugated
Item Number
Ab131831
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab131831-10μl
10μl
In stock
$66.90
Ab131831-50μl
50μl
In stock
$199.90
Ab131831-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$299.90
Ab131831-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,499.90

Recombinant; Rabbit anti Human TNF Receptor II Antibody; WB; Unconjugated

Basic Description

Product NameRecombinant TNF Receptor II Antibody - Primary antibody, specific to TNF Receptor II, Rabbit IgG
SynonymsCD120b antibody | p75 antibody | p75 TNF receptor antibody | p75TNFR antibody | p80 TNF alpha receptor antibody | p80 TNF-alpha receptor antibody | Soluble TNFR1B variant 1 antibody | TBP-2 antibody | TBPII antibody | TNF R II antibody | TNF R2 antibody |
Specifications & PurityExactAb™, Validated, Recombinant, 0.5 mg/mL
Host speciesRabbit
SpecificityTNF Receptor II
ImmunogenA synthetic peptide derived from human TNF Receptor II (AA 415-461)
Positive ControlWB: Jurkat, MCF7, HeLa, THP-1 and K562 cell lysates.
ConjugationUnconjugated
GradeExactAb™, Recombinant, Validated
Product Description

Rabbit anti Human TNF Receptor II Antibody, Recombinant, could be used for WB and so on.
Application
WB: 1/500-1/1000
Protein Function
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.

Product Properties

IsotypeRabbit IgG
Light Chain Typekappa
SDS-PAGE150 kDa
Purification MethodProtein A purified
FormLiquid
Concentration0.5 mg/mL
Storage TempStore at -20°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at 4℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Images

Recombinant TNF Receptor II Antibody (Ab131831) - Western Blot
All lanes: Recombinant TNF Receptor II Antibody (Ab131831) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 48 kDa
Observed band size: 68 kDa
Exposure time: 12.9 s

Associated Targets(Human)

TNFRSF1B Tbio Tumor necrosis factor receptor superfamily member 1B (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Application

ApplicationDilution info
WB1/500-1/1000

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1/500-1/1000

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

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2 results found

Lot NumberCertificate TypeDateItem
ZJ24F0505948Certificate of AnalysisMay 22, 2024 Ab131831
ZJ24F0505949Certificate of AnalysisMay 22, 2024 Ab131831

Related Documents

References

1. Pennica, D D and 7 more authors..  (1992)  Biochemical properties of the 75-kDa tumor necrosis factor receptor. Characterization of ligand binding, internalization, and receptor phosphorylation..  The Journal of biological chemistry,    (15):   [PMID:1328224]
2. Dembic, Z Z and 7 more authors..  (1990)  Two human TNF receptors have similar extracellular, but distinct intracellular, domain sequences..  Cytokine,      [PMID:1966549]
3. Engelmann, H H, Novick, D D and Wallach, D D..  (1990)  Two tumor necrosis factor-binding proteins purified from human urine. Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors..  The Journal of biological chemistry,    (25):   [PMID:2153136]
4. Smith, C A CA and 8 more authors..  (1990)  A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins..  Science (New York, N.Y.),    (25):   [PMID:2160731]
5. Heller, R A RA and 5 more authors..  (1990)  Complementary DNA cloning of a receptor for tumor necrosis factor and demonstration of a shed form of the receptor..  Proceedings of the National Academy of Sciences of the United States of America,      [PMID:2166946]
6. Kohno, T T and 8 more authors..  (1990)  A second tumor necrosis factor receptor gene product can shed a naturally occurring tumor necrosis factor inhibitor..  Proceedings of the National Academy of Sciences of the United States of America,      [PMID:2172983]
7. Loetscher, H H and 5 more authors..  (1990)  Purification and partial amino acid sequence analysis of two distinct tumor necrosis factor receptors from HL60 cells..  The Journal of biological chemistry,    (25):   [PMID:2173696]
8. Suzuki, J J and 5 more authors..  (1994)  Purification of two types of TNF inhibitors in the urine of the patient with chronic glomerulonephritis..  Nephron,      [PMID:8015639]
9. Rothe, M M, Wong, S C SC, Henzel, W J WJ and Goeddel, D V DV..  (1994)  A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor..  Cell,    (26):   [PMID:8069916]
10. Beltinger, C P CP and 9 more authors..  (1996)  Physical mapping and genomic structure of the human TNFR2 gene..  Genomics,    (1):   [PMID:8661109]
11. Park, Y C YC, Burkitt, V V, Villa, A R AR, Tong, L L and Wu, H H..  (1999)  Structural basis for self-association and receptor recognition of human TRAF2..  Nature,    (8):   [PMID:10206649]
12. Tsuchiya, N N, Komata, T T, Matsushita, M M, Ohashi, J J and Tokunaga, K K..  (2000)  New single nucleotide polymorphisms in the coding region of human TNFR2: association with systemic lupus erythematosus..  Genes and immunity,      [PMID:11197692]
13. Morita, C C and 10 more authors..  (2001)  Association of tumor necrosis factor receptor type II polymorphism 196R with Systemic lupus erythematosus in the Japanese: molecular and functional analysis..  Arthritis and rheumatism,      [PMID:11762942]
14. Peral, Belén B, San Millán, José L JL, Castello, Roberto R, Moghetti, Paolo P and Escobar-Morreale, Héctor F HF..  (2002)  Comment: the methionine 196 arginine polymorphism in exon 6 of the TNF receptor 2 gene (TNFRSF1B) is associated with the polycystic ovary syndrome and hyperandrogenism..  The Journal of clinical endocrinology and metabolism,      [PMID:12161545]
15. Pan, Shi S and 5 more authors..  (2002)  Etk/Bmx as a tumor necrosis factor receptor type 2-specific kinase: role in endothelial cell migration and angiogenesis..  Molecular and cellular biology,      [PMID:12370298]
16. Lainez, Begoña B and 6 more authors..  (2004)  Identification and characterization of a novel spliced variant that encodes human soluble tumor necrosis factor receptor 2..  International immunology,      [PMID:14688072]
17. Gregory, S G SG and 178 more authors..  (2006)  The DNA sequence and biological annotation of human chromosome 1..  Nature,    (18):   [PMID:16710414]

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