Recombinant Troponin I/TNNI3 Antibody - Primary antibody, for LF,GICA,FIA,Capture antibody in LF various applications, from Human, generated in Mouse, specific to CTnI, IgG1

Features and benefits
  • Short Overview:

    Recombinant (24A5); Mouse anti Human Troponin I/TNNI3 a ntibody; LF, GICA, FIA, Capture antibody in LF, GICA; Unconjugated

  • Application: LF,GICA,FIA,Capture antibody in LF
  • Species reactivity(Reacts with): Human
  • Isotype: IgG1
    Application:
  • Capture Antibody
  • ELISA
  • FIA
  • GICA
  • LF
Item Number
Ab005499
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab005499-10μg
10μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$59.90
Ab005499-50μg
50μg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$177.90
Ab005499-100μg
100μg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$267.90
Ab005499-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$447.90

Recombinant (24A5); Mouse anti Human Troponin I/TNNI3 a ntibody; LF, GICA, FIA, Capture antibody in LF, GICA; Unconjugated

Basic Description

Product NameRecombinant Troponin I/TNNI3 Antibody - Primary antibody, for LF,GICA,FIA,Capture antibody in LF various applications, from Human, generated in Mouse, specific to CTnI, IgG1
SynonymsCardiac troponin I; CMD1FF; CMD2A; CMH7MGC116817; CTnI; familial hypertrophic cardiomyopathy 7; RCM1; TNNC1; TNNC1troponin I, cardiac; TNNI3,; troponin I type 3 (cardiac); troponin I, cardiac muscle; Troponin I/TNNI3
Specifications & PurityExactAb™, Validated, Carrier Free, Azide Free, Recombinant, Lot by Lot
Host SpeciesMouse
Host speciesMouse
SpecificityCTnI
ApplicationLF,GICA,FIA,Capture antibody in LF
ImmunogenE. coli-derived recombinant human CTNI
Epitope41-49 aa
ConjugationUnconjugated
GradeAzide Free, Carrier Free, ExactAb™, Recombinant, Validated
Product Description

Recombinant Troponin I/TNNI3 Antibody, 24A5, is a Capture antibody could be used for LF, GICA at 1.0 mg/mL

Product Properties

Antibody TypePrimary antibody
ClonalityRecombinant
IsotypeIgG1
Purification MethodProtein A purified
Matched Pairs[Ab005500] Recombinant Troponin I/TNNI3 antibody as Detection antibody in LF, GICA
SourceCHO supernatant
FormLiquid
ConcentrationLot by Lot
Storage TempStore at -20°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStorage: -20℃ for long term storage. Avoid repeated freeze/thaw cycles.

Images

Recombinant Troponin I/TNNI3 Antibody (Ab005499)-Binding ELISA
The binding activity of recombinant Troponin I/TNNI3 antibody with Troponin I/TNNI3 antigen. 

Troponin I/TNNI3 Standard Curve with Antibody Pair (Ab005499 & Ab005748 & Ab005751 & Ab005500) in GICA

·Capture antibody: Recombinant Troponin I/TNNI3 Antibody (Ab005499 & Ab005748 & Ab005751) at 1.0 mg/mL. 

·Detection antibody: Recombinant Troponin I/TNNI3 Antibody (Ab005500) at 1.0 mg/mL.

·Linear Range: 0.08-100 ng/mL, LLOD: 0.08 ng/mL.

Associated Targets(Human)

TNNI3 Tbio Troponin I, cardiac muscle (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot NumberCertificate TypeDateItem
ZJ23F0600269Certificate of AnalysisJun 07, 2023 Ab005499
ZJ23F0600268Certificate of AnalysisJun 07, 2023 Ab005499

Related Documents

References

1. Hunkeler, N M NM, Kullman, J J and Murphy, A M AM..  (1991)  Troponin I isoform expression in human heart..  Circulation research,      [PMID:1934363]
2. Vallins, W J WJ and 5 more authors..  (1990)  Molecular cloning of human cardiac troponin I using polymerase chain reaction..  FEBS letters,    (17):   [PMID:2226790]
3. Mittmann, K K, Jaquet, K K and Heilmeyer, L M LM..  (1990)  A common motif of two adjacent phosphoserines in bovine, rabbit and human cardiac troponin I..  FEBS letters,    (29):   [PMID:2226863]
4. Armour, K L KL, Harris, W J WJ and Tempest, P R PR..  (1993)  Cloning and expression in Escherichia coli of the cDNA encoding human cardiac troponin I..  Gene,    (15):   [PMID:8406024]
5. Bhavsar, P K PK, Brand, N J NJ, Yacoub, M H MH and Barton, P J PJ..  (1996)  Isolation and characterization of the human cardiac troponin I gene (TNNI3)..  Genomics,    (1):   [PMID:8661099]
6. Kimura, A A and 23 more authors..  (1997)  Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy..  Nature genetics,      [PMID:9241277]
7. Keane, N E NE and 5 more authors..  (1997)  The ordered phosphorylation of cardiac troponin I by the cAMP-dependent protein kinase--structural consequences and functional implications..  European journal of biochemistry,    (1):   [PMID:9346285]
8. Li, M X MX, Spyracopoulos, L L and Sykes, B D BD..  (1999)  Binding of cardiac troponin-I147-163 induces a structural opening in human cardiac troponin-C..  Biochemistry,    (29):   [PMID:10387074]
9. Niimura, Hideshi H and 6 more authors..  (2002)  Sarcomere protein gene mutations in hypertrophic cardiomyopathy of the elderly..  Circulation,    (29):   [PMID:11815426]
10. Wang, Xu X, Li, Monica X MX and Sykes, Brian D BD..  (2002)  Structure of the regulatory N-domain of human cardiac troponin C in complex with human cardiac troponin I147-163 and bepridil..  The Journal of biological chemistry,    (23):   [PMID:12060657]
11. Buscemi, Nina N, Foster, D Brian DB, Neverova, Irina I and Van Eyk, Jennifer E JE..  (2002)  p21-activated kinase increases the calcium sensitivity of rat triton-skinned cardiac muscle fiber bundles via a mechanism potentially involving novel phosphorylation of troponin I..  Circulation research,    (20):   [PMID:12242269]
12. Mogensen, Jens J and 8 more authors..  (2003)  Idiopathic restrictive cardiomyopathy is part of the clinical expression of cardiac troponin I mutations..  The Journal of clinical investigation,      [PMID:12531876]
13. Richard, Pascale P and 16 more authors..  (2003)  Hypertrophic cardiomyopathy: distribution of disease genes, spectrum of mutations, and implications for a molecular diagnosis strategy..  Circulation,    (6):   [PMID:12707239]
14. Erdmann, J J and 10 more authors..  (2003)  Mutation spectrum in a large cohort of unrelated consecutive patients with hypertrophic cardiomyopathy..  Clinical genetics,      [PMID:12974739]
15. Murphy, Ross T RT and 5 more authors..  (2004)  Novel mutation in cardiac troponin I in recessive idiopathic dilated cardiomyopathy..  Lancet (London, England),    (31):   [PMID:15070570]
16. Haworth, Robert S RS and 6 more authors..  (2004)  Protein kinase D is a novel mediator of cardiac troponin I phosphorylation and regulates myofilament function..  Circulation research,    (26):   [PMID:15514163]
17. Kedar, Vishram V and 5 more authors..  (2004)  Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I..  Proceedings of the National Academy of Sciences of the United States of America,    (28):   [PMID:15601779]
18. Ingles, J J and 5 more authors..  (2005)  Compound and double mutations in patients with hypertrophic cardiomyopathy: implications for genetic testing and counselling..  Journal of medical genetics,      [PMID:16199542]
19. You, Bei B and 7 more authors..  (2009)  Phosphorylation of cardiac troponin I by mammalian sterile 20-like kinase 1..  The Biochemical journal,    (15):   [PMID:18986304]
20. Carballo, Sebastian S and 9 more authors..  (2009)  Identification and functional characterization of cardiac troponin I as a novel disease gene in autosomal dominant dilated cardiomyopathy..  Circulation research,    (14):   [PMID:19590045]
21. Millat, Gilles G and 13 more authors..  ()  Clinical and mutational spectrum in a cohort of 105 unrelated patients with dilated cardiomyopathy..  European journal of medical genetics,      [PMID:21846512]
22. Zhang, Pingbo P and 6 more authors..  (2012)  Multiple reaction monitoring to identify site-specific troponin I phosphorylated residues in the failing human heart..  Circulation,    (9):   [PMID:22972900]

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