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Regorafenib (BAY 73-4506) - ≥99%, high purity , Nerve growth factor receptor Trk-A, CAS No.755037-03-7, Nerve growth factor receptor Trk-A

Moligand™
≥99%

CAS#: 755037-03-7
Formula: C₂₁H₁₅ClF₄N₄O₃
Molecular Weight: 482.82
MDL number: MFCD16038047
PubChem CID: 11167602

Item Number

R127804

Grouped product items
SKU	Size	Availability	Price
R127804-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$35.90
R127804-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$58.90
R127804-25mg	25mg	In stock	$132.90
R127804-100mg	100mg	In stock	$177.90
R127804-500mg	500mg	In stock	$801.90

Potent multikinase inhibitor

View related series

B-Raf proto-oncogene，serine/threonine kinase Inhibitor kinase insert domain receptor Inhibitor

Basic Description

Synonyms	Regorafenib\|755037-03-7\|BAY 73-4506\|Stivarga\|4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide\|Regorafenibum\|BAY73-4506\|Regorafenib (BAY 73-4506)\|BAY-73-4506\|4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amin
Specifications & Purity	Moligand™, ≥99%
Biochemical and Physiological Mechanisms	Potent\xa0multikinase inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, RET and Raf-1 (IC 50 values are 13, 4.2, 46, 22, 7, 1.5 and 2.5nM, respectively). Orally bioavailable antitumor, antiangiogenic, antiproliferative and antineoplastic agent.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Nerve growth factor receptor Trk-A
Product Description	Regorafenib (BAY 73-4506) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively.

Names and Identifiers

IUPAC Name	4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide
INCHI	InChI=1S/C21H15ClF4N4O3/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26/h2-10H,1H3,(H,27,31)(H2,29,30,32)
InChi Key	FNHKPVJBJVTLMP-UHFFFAOYSA-N
Canonical SMILES	CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F
Isomeric SMILES	CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F
PubChem CID	11167602
Molecular Weight	482.82

PubChem CID

CAS Registry No.

ChEMBL Ligand

ChEBI

Wikipedia

DrugBank Ligand

PEP

Reactome Reaction

R-HSA-6802938, R-HSA-9669854, R-HSA-9669900, R-HSA-9674430, R-HSA-9674095, R-HSA-9669870, R-HSA-9674408

Reactome Drug

R-ALL-9657514

DrugCentral Ligand

4654

Certificates

Certificate of Analysis(COA)

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10 results found

Lot Number	Certificate Type	Date	Item
F1502104	Certificate of Analysis	Jan 25, 2023	R127804
A2305736	Certificate of Analysis	Nov 10, 2022	R127804
A2305737	Certificate of Analysis	Nov 10, 2022	R127804
A2305740	Certificate of Analysis	Nov 10, 2022	R127804
A2305809	Certificate of Analysis	Nov 10, 2022	R127804
A2305815	Certificate of Analysis	Nov 10, 2022	R127804
A2305850	Certificate of Analysis	Nov 10, 2022	R127804
H1814073	Certificate of Analysis	May 09, 2022	R127804
H1814072	Certificate of Analysis	May 09, 2022	R127804
G1806033	Certificate of Analysis	Apr 14, 2022	R127804

Solubility

DMSO ≥95mg/mL;Water <1 mg/mL;Ethanol <1 mg/mL

Sensitivity

Heat Sensitive

Melt Point(°C)

208 °C

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS09, GHS07
Signal	Danger
Hazard Statements	H302:Harmful if swallowed H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects H372:Causes damage to organs through prolonged or repeated exposure H360:May damage fertility or the unborn child H362:May cause harm to breast-fed children
Precautionary Statements	P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P391:Collect spillage. P330:Rinse mouth. P263:Avoid contact during pregnancy/while nursing. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P319:Get medical help if you feel unwell.

References

1. Hafner FT, Werner D, Kaiser M. (2014) Determination of regorafenib (BAY 73-4506) and its major human metabolites BAY 75-7495 (M-2) and BAY 81-8752 (M-5) in human plasma by stable-isotope dilution liquid chromatography-tandem mass spectrometry.. Bioanalysis, 6 (14): (1923-37). [PMID:25158964]

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Regorafenib (BAY 73-4506) - ≥99%, high purity , Nerve growth factor receptor Trk-A, CAS No.755037-03-7, Nerve growth factor receptor Trk-A

Basic Description

Product Properties

Names and Identifiers

Database links