Grouped product items

SKU

Size

Availability

Price

Qty

R287694-10mg

10mg

In stock

$642.90

R287694-50mg

50mg

In stock

$11.90

R287694-100mg

100mg

Available within 4-8 weeks(?)

$18.90

R287694-250mg

250mg

Available within 4-8 weeks(?)

$36.90

R287694-500mg

500mg

In stock

$66.90

R287694-1g

In stock

$120.90

R287694-5g

In stock

$423.90

R287694-25g

25g

Available within 4-8 weeks(?)

$1,483.90

Basic Description

Synonyms	compound 4b [PMID: 28124907] \| SCHEMBL17712225 \| GS5734 \| GS-5734 \| HB9521 \| (2S)-2-{(2R,3S,4R,5R)-[5-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxy]phenoxy-(S)-phosphorylamino}propionic acid 2-ethyl-butyl es
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Viral RNA-dependent RNA polymerase inhibitor (RdRp) and broad spectrum antiviral nucleotide prodrug. Metabolized to active form,GS 441524. Exhibits activity against a range of RNA virusesin vitro(EC50values are 0.019, 0.07, 0.07 - 0.34, 0.086 - 0.14, and
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Replicase polyprotein 1ab inhibitor

Product Properties

ALogP	1.9

Associated Targets(Human)

Homo sapiens (32628 Activities)

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Caco-2 (12174 Activities)

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Calu-3 (339 Activities)

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HCT-8 (3484 Activities)

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Huh-7 (12904 Activities)

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MRC5 (9203 Activities)

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MT4 (17854 Activities)

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A549 (127892 Activities)

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HEL 299 (144 Activities)

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HEp-2 (3859 Activities)

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HepG2 (196354 Activities)

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Macrophage cell line (190 Activities)

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HeLa (62764 Activities)

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PBMC (10003 Activities)

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HEK-293T (167025 Activities)

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16HBE14o- (68 Activities)

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Associated Targets(non-human)

Human orthopneumovirus (392 Activities)

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Influenza B virus (2113 Activities)

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Sindbis virus (1599 Activities)

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Yellow fever virus (1530 Activities)

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Hepatitis C virus (23859 Activities)

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Murine hepatitis virus (113 Activities)

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Influenza A virus (11224 Activities)

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Respiratory syncytial virus (3434 Activities)

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BHK-21 (725 Activities)

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MDCK (10148 Activities)

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Vero (26788 Activities)

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Human coronavirus 229E (235 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

dengue virus type 2 (2400 Activities)

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Brain (1 Activities)

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Plasma (328 Activities)

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Lassa virus (234 Activities)

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Nipah virus (19 Activities)

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Vero 76 (245 Activities)

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Middle East respiratory syndrome-related coronavirus (220 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Zika virus (1028 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

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SARS-CoV (424 Activities)

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Vero C1008 (1716 Activities)

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Ebolavirus (617 Activities)

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Junin virus (193 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NS5 (58 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Human coronavirus OC43 (66 Activities)

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Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	2-ethylbutyl (2S)-2-[[[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxyoxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate
INCHI	InChI=1S/C27H35N6O8P/c1-4-18(5-2)13-38-26(36)17(3)32-42(37,41-19-9-7-6-8-10-19)39-14-21-23(34)24(35)27(15-28,40-21)22-12-11-20-25(29)30-16-31-33(20)22/h6-12,16-18,21,23-24,34-35H,4-5,13-14H2,1-3H3,(H,32,37)(H2,29,30,31)/t17-,21+,23+,24+,27-,42-/m0/s1
InChi Key	RWWYLEGWBNMMLJ-YSOARWBDSA-N
Canonical SMILES	CCC(CC)COC(=O)C(C)NP(=O)(OCC1C(C(C(O1)(C#N)C2=CC=C3N2N=CN=C3N)O)O)OC4=CC=CC=C4
Isomeric SMILES	CCC(CC)COC(=O)[C@H](C)N[P@](=O)(OC[C@@H]1[C@H]([C@H]([C@](O1)(C#N)C2=CC=C3N2N=CN=C3N)O)O)OC4=CC=CC=C4
PubChem CID	121304016
Molecular Weight	602.58

Database links

PubChem CID	121304016
CAS Registry No.	1809249-37-3
ChEMBL Ligand	CHEMBL4065616
Reactome Reaction	R-HSA-9680262, R-HSA-9687384, R-HSA-9687388, R-HSA-9694419, R-HSA-9694665, R-HSA-9694541
Reactome Drug	R-ALL-9680278
DrugCentral Ligand	5376

Certificates

Certificate of Analysis(COA)

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Find and download the COA for your product by matching the lot number on the packaging.

14 results found

Lot Number	Certificate Type	Date	Item
G2411025	Certificate of Analysis	Oct 25, 2023	R287694
G2411041	Certificate of Analysis	Oct 25, 2023	R287694
J2411076	Certificate of Analysis	Oct 25, 2023	R287694
K2310125	Certificate of Analysis	Oct 25, 2023	R287694
K2310126	Certificate of Analysis	Oct 25, 2023	R287694
K2310131	Certificate of Analysis	Oct 25, 2023	R287694
K2310132	Certificate of Analysis	Oct 25, 2023	R287694
K2310133	Certificate of Analysis	Oct 25, 2023	R287694
G2220798	Certificate of Analysis	Jun 16, 2022	R287694
G2220799	Certificate of Analysis	Jun 16, 2022	R287694
G2220800	Certificate of Analysis	Jun 16, 2022	R287694
G2220801	Certificate of Analysis	Jun 16, 2022	R287694
G2220802	Certificate of Analysis	Jun 16, 2022	R287694
G2220804	Certificate of Analysis	Jun 16, 2022	R287694

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Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 60.26, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 12.05, Max Conc. mM: 20

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H373:Causes damage to organs through prolonged or repeated exposure H302:Harmful if swallowed H372:Causes damage to organs through prolonged or repeated exposure
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

Alternative Products

References

1. Siegel D, Hui HC, Doerffler E, Clarke MO, Chun K, Zhang L, Neville S, Carra E, Lew W, Ross B et al.. (2017) Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses.. J Med Chem, 60 (5): (1648-1661). [PMID:28124907]
2. Sheahan TP, Sims AC, Graham RL, Menachery VD, Gralinski LE, Case JB, Leist SR, Pyrc K, Feng JY, Trantcheva I et al.. (2017) Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses.. Sci Transl Med, 9 (396): (1755-70). [PMID:28659436]
3. Lamb YN. (2020) Remdesivir: First Approval.. Drugs, 80 (13): (1355-1363). [PMID:32870481]
4. Agostini ML, Andres EL, Sims AC, Graham RL, Sheahan TP, Lu X, Smith EC, Case JB, Feng JY, Jordan R et al.. (2018) Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease.. mBio, 9 (2): (1755-70). [PMID:29511076]
5. Holshue ML, DeBolt C, Lindquist S, Lofy KH, Wiesman J, Bruce H, Spitters C, Ericson K, Wilkerson S, Tural A et al.. (2020) First Case of 2019 Novel Coronavirus in the United States.. N Engl J Med, 382 (10): (929-936). [PMID:32004427]
6. Grein J, Ohmagari N, Shin D, Diaz G, Asperges E, Castagna A, Feldt T, Green G, Green ML, Lescure FX et al.. (2020) Compassionate Use of Remdesivir for Patients with Severe Covid-19.. N Engl J Med, 382 (24): (2327-2336). [PMID:32275812]
7. Gordon CJ, Tchesnokov EP, Woolner E, Perry JK, Feng JY, Porter DP, Götte M. (2020) Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency.. J Biol Chem, 295 (20): (6785-6797). [PMID:32284326]

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Remdesivir - ≥98%(HPLC), high purity , Replicase polyprotein 1ab inhibitor, CAS No.1809249-37-3, Replicase polyprotein 1ab inhibitor

Basic Description

Product Properties

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Show more⌵

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Alternative Products

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator