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Remdesivir - ≥98%(HPLC), high purity , Replicase polyprotein 1ab inhibitor, CAS No.1809249-37-3, Replicase polyprotein 1ab inhibitor

  • Moligand™
  • ≥98%(HPLC)
Item Number
R287694
Grouped product items
SKUSizeAvailabilityPrice Qty
R287694-10mg
10mg
In stock
$642.90
R287694-50mg
50mg
In stock
$11.90
R287694-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$18.90
R287694-250mg
250mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$36.90
R287694-500mg
500mg
In stock
$66.90
R287694-1g
1g
In stock
$120.90
R287694-5g
5g
In stock
$423.90
R287694-25g
25g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,483.90
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Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral nucelotide prodrug

View related series
CoV RNA-dependent RNA polymerase Inhibitor SARS-CoV RNA-dependent RNA polymerase Inhibitor

Basic Description

Synonyms1809249-37-3|3QKI37EEHE|GS 5734|GS 5734 [WHO-DD]|GS-5734|GS5734|Remdesivir|REMDESIVIR [INN]|Remdesivir [USAN]|REMDESIVIR [WHO-DD]|remdesivirum|UNII-3QKI37EEHE|Veklury|2-ethylbutyl (2S)-2-[[[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyan
Specifications & Purity≥98%(HPLC)
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionReplicase polyprotein 1ab inhibitor

Product Properties

ALogP1.9

Names and Identifiers

IUPAC Name 2-ethylbutyl (2S)-2-[[[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxyoxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate
INCHI InChI=1S/C27H35N6O8P/c1-4-18(5-2)13-38-26(36)17(3)32-42(37,41-19-9-7-6-8-10-19)39-14-21-23(34)24(35)27(15-28,40-21)22-12-11-20-25(29)30-16-31-33(20)22/h6-12,16-18,21,23-24,34-35H,4-5,13-14H2,1-3H3,(H,32,37)(H2,29,30,31)/t17-,21+,23+,24+,27-,42-/m0/s1
InChi Key RWWYLEGWBNMMLJ-YSOARWBDSA-N
Canonical SMILES CCC(CC)COC(=O)C(C)NP(=O)(OCC1C(C(C(O1)(C#N)C2=CC=C3N2N=CN=C3N)O)O)OC4=CC=CC=C4
Isomeric SMILES CCC(CC)COC(=O)[C@H](C)N[P@](=O)(OC[C@@H]1[C@H]([C@H]([C@](O1)(C#N)C2=CC=C3N2N=CN=C3N)O)O)OC4=CC=CC=C4
PubChem CID 121304016
Molecular Weight 602.58

Certificates

Certificate of Analysis(COA)

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13 results found

Lot NumberCertificate TypeDateItem
G2411025Certificate of AnalysisOct 25, 2023 R287694
G2411041Certificate of AnalysisOct 25, 2023 R287694
K2310125Certificate of AnalysisOct 25, 2023 R287694
K2310126Certificate of AnalysisOct 25, 2023 R287694
K2310131Certificate of AnalysisOct 25, 2023 R287694
K2310132Certificate of AnalysisOct 25, 2023 R287694
K2310133Certificate of AnalysisOct 25, 2023 R287694
G2220798Certificate of AnalysisJun 16, 2022 R287694
G2220799Certificate of AnalysisJun 16, 2022 R287694
G2220800Certificate of AnalysisJun 16, 2022 R287694
G2220801Certificate of AnalysisJun 16, 2022 R287694
G2220802Certificate of AnalysisJun 16, 2022 R287694
G2220804Certificate of AnalysisJun 16, 2022 R287694

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Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 60.26, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 12.05, Max Conc. mM: 20

Safety and Hazards(GHS)

Pictogram(s) GHS08,   GHS07
Signal Danger
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H373:Causes damage to organs through prolonged or repeated exposure

H302:Harmful if swallowed

H372:Causes damage to organs through prolonged or repeated exposure

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P317:IF SWALLOWED: Get medical help.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

Related Documents

 SDS

 Specification Sheet

Alternative Products

  1. Remdesivir (GS-5734) - 10mM in DMSO, used for , CAS No. 1809249-37-3(DMSO), by Aladdin Scientific
    Remdesivir (GS-5734)

    Starting at $429.90

References

1. Siegel D, Hui HC, Doerffler E, Clarke MO, Chun K, Zhang L, Neville S, Carra E, Lew W, Ross B et al..  (2017)  Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses..  J Med Chem,  60  (5): (1648-1661).  [PMID:28124907]
2. Sheahan TP, Sims AC, Graham RL, Menachery VD, Gralinski LE, Case JB, Leist SR, Pyrc K, Feng JY, Trantcheva I et al..  (2017)  Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses..  Sci Transl Med,  9  (396): (589-97).  [PMID:28659436]
3. Lamb YN.  (2020)  Remdesivir: First Approval..  Drugs,  80  (13): (1355-1363).  [PMID:32870481]
4. Agostini ML, Andres EL, Sims AC, Graham RL, Sheahan TP, Lu X, Smith EC, Case JB, Feng JY, Jordan R et al..  (2018)  Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease..  mBio,  9  (2): (589-97).  [PMID:29511076]
5. Holshue ML, DeBolt C, Lindquist S, Lofy KH, Wiesman J, Bruce H, Spitters C, Ericson K, Wilkerson S, Tural A et al..  (2020)  First Case of 2019 Novel Coronavirus in the United States..  N Engl J Med,  382  (10): (929-936).  [PMID:32004427]
6. Grein J, Ohmagari N, Shin D, Diaz G, Asperges E, Castagna A, Feldt T, Green G, Green ML, Lescure FX et al..  (2020)  Compassionate Use of Remdesivir for Patients with Severe Covid-19..  N Engl J Med,  382  (24): (2327-2336).  [PMID:32275812]
7. Gordon CJ, Tchesnokov EP, Woolner E, Perry JK, Feng JY, Porter DP, Götte M.  (2020)  Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency..  J Biol Chem,  295  (20): (6785-6797).  [PMID:32284326]

Solution Calculators

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