Remogliflozin etabonate (GSK189075) - 10mM in DMSO, high purity , CAS No.442201-24-3

Item Number

R423992

Grouped product items
SKU	Size	Availability	Price	Qty
R423992-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$667.90

SGLT2 Selective Inhibitors

Basic Description

Synonyms	remogliflozin etabonate \| 442201-24-3 \| GSK-189075 \| GSK189075A \| GSK-189075A \| GSK 189075 \| Remogliflozin etabonate [INN] \| TR0QT6QSUL \| GSK189075 \| BHV-091009 \| ethyl (((2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-((4-(4-isopropoxybenzyl)-1-isopropyl-5-methyl-1H-pyrazol-3-yl)oxy)te
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Remogliflozin etabonate (GSK189075) is an orally active, selective and low-affinity inhibitor of sodium glucose cotransporter (SGLT2) with Ki of 1950 nM, 2140 nM, 43100 nM, 8570 nM for hSGLT2, rSGLT2, hSGLT1, rSGLT1, respectively. Remogliflozin etabonate
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	Information Remogliflozin etabonate (GSK189075) is an orally active, selective and low-affinity inhibitor ofsodium glucose cotransporter (SGLT2)with Ki of 1950 nM, 2140 nM, 43100 nM, 8570 nM for hSGLT2, rSGLT2, hSGLT1, rSGLT1, respectively. Remogliflozin etabonate exhibits antidiabetic efficacy in rodent models. Targets hSGLT2 (Cell-free assay); rSGLT2 (Cell-free assay); rSGLT1 (Cell-free assay); hSGLT1 (Cell-free assay) 1950 nM(Ki); 2140 nM(Ki); 8570 nM(Ki); 43100 nM(Ki)

Associated Targets(non-human)

Slc5a1 Sodium/glucose cotransporter 1 (11 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Slc5a2 Sodium/glucose cotransporter 2 (17 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	ethyl [(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[5-methyl-1-propan-2-yl-4-[(4-propan-2-yloxyphenyl)methyl]pyrazol-3-yl]oxyoxan-2-yl]methyl carbonate
INCHI	InChI=1S/C26H38N2O9/c1-7-33-26(32)34-13-20-21(29)22(30)23(31)25(36-20)37-24-19(16(6)28(27-24)14(2)3)12-17-8-10-18(11-9-17)35-15(4)5/h8-11,14-15,20-23,25,29-31H,7,12-13H2,1-6H3/t20-,21-,22+,23-,25+/m1/s1
InChi Key	UAOCLDQAQNNEAX-ABMICEGHSA-N
Canonical SMILES	CCOC(=O)OCC1C(C(C(C(O1)OC2=NN(C(=C2CC3=CC=C(C=C3)OC(C)C)C)C(C)C)O)O)O
Isomeric SMILES	CCOC(=O)OC[C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)OC2=NN(C(=C2CC3=CC=C(C=C3)OC(C)C)C)C(C)C)O)O)O
PubChem CID	9871420
Molecular Weight	522.59

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Basic Description