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Resiquimod - ≥98%(HPLC), high purity , CAS No.144875-48-9, Agonist of TLR7;Agonist of TLR8

Moligand™

≥98%(HPLC)

CAS#: 144875-48-9
Formula: C₁₇H₂₂N₄O₂
Molecular Weight: 314.38
MDL number: MFCD00937759
PubChem CID: 159603

Item Number

R131891

Grouped product items
SKU	Size	Availability	Price
R131891-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$112.90
R131891-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$179.90
R131891-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$326.90
R131891-1g	1g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$919.90
R131891-5g	5g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$3,219.90

Toll-like receptor 7 (TLR7) agonist

View related series

TLR7 Agonist TLR8 Agonist

Basic Description

Synonyms	R848 \| R 848 \| S 28463 \| R-848 \| Resiquimod [INN] \| 1-(4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol. \| 1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol \| s28463 \| R848;S28463 \| Resiquimod (GMP
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Toll-like receptor 7 (TLR7) agonist. Induces upregulation of IL-6, IL-12, IFN-γand iNOS expression in mouse bone marrow-derived macrophages (BMMs). Inhibits RANKL-induced osteoclast differentiation in mouse BMMs and human peripheral blood monocytes. Also
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of TLR7;Agonist of TLR8
Note	200mg 售完停产

Product Properties

ALogP	1.3

Associated Targets(Human)

TLR8 Tchem Toll-like receptor 8 (1 Activities)

Discover Target: TLR8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TLR7 Tclin Toll-like receptor 7 (5 Activities)

Discover Target: TLR7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HEK293 (82097 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PBMC (10003 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TLR8 Tchem Toll-like receptor 8 (1853 Activities)

Discover Target: TLR8

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NUDT1 Tchem 7,8-dihydro-8-oxoguanine triphosphatase (280 Activities)

Discover Target: NUDT1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Pseudomonas aeruginosa (123386 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Klebsiella pneumoniae (43867 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Staphylococcus aureus (210822 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Acinetobacter baumannii (41033 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Escherichia coli (133304 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cryptococcus neoformans (21258 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Candida albicans (78123 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mustela putorius furo (1007 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Hepatitis C virus (23859 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Splenocyte (1641 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cynomolgus monkey (4946 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CT26 (928 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Tlr7 Toll-like receptor 7 (174 Activities)

Discover Target: Tlr7

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasma (328 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Tlr7 TLR7 and TLR8 (70 Activities)

Discover Target: Tlr7

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TLR7 Toll-like receptor 7/8 (156 Activities)

Discover Target: TLR7

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	1-[4-amino-2-(ethoxymethyl)imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol
INCHI	InChI=1S/C17H22N4O2/c1-4-23-9-13-20-14-15(21(13)10-17(2,3)22)11-7-5-6-8-12(11)19-16(14)18/h5-8,22H,4,9-10H2,1-3H3,(H2,18,19)
InChi Key	BXNMTOQRYBFHNZ-UHFFFAOYSA-N
Canonical SMILES	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N
Isomeric SMILES	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N
WGK Germany	3
RTECS	NJ5911320
PubChem CID	159603
Molecular Weight	314.38

Database links

Wikipedia	Resiquimod
ChEBI	CHEBI:36706
CAS Registry No.	144875-48-9
PubChem CID	159603
ChEMBL Ligand	CHEMBL383322
RCSB PDB Ligand	RX8

Certificates

Certificate of Analysis(COA)

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15 results found

Lot Number	Certificate Type	Date	Item
G2401033	Certificate of Analysis	Jul 10, 2024	R131891
G2409127	Certificate of Analysis	Jun 22, 2024	R131891
G2409128	Certificate of Analysis	Jun 22, 2024	R131891
G2409129	Certificate of Analysis	Jun 22, 2024	R131891
G2409130	Certificate of Analysis	Jun 22, 2024	R131891
G2409131	Certificate of Analysis	Jun 22, 2024	R131891
F2414041	Certificate of Analysis	Jun 20, 2024	R131891
H2222101	Certificate of Analysis	Jun 20, 2024	R131891
H2222106	Certificate of Analysis	Jun 20, 2024	R131891
H2222107	Certificate of Analysis	Jun 20, 2024	R131891
D2416463	Certificate of Analysis	Mar 11, 2024	R131891
D2428397	Certificate of Analysis	Mar 11, 2024	R131891
H2222098	Certificate of Analysis	Aug 02, 2022	R131891
H2331037	Certificate of Analysis	Aug 02, 2022	R131891
I2305257	Certificate of Analysis	Aug 02, 2022	R131891

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 31.44, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 15.72, Max Conc. mM: 50
Sensitivity	Moisture sensitive；Heat sensitive
Melt Point(°C)	193℃

Safety and Hazards(GHS)

WGK Germany	3
RTECS	NJ5911320

Alternative Products

References

1. Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, Horiuchi T, Tomizawa H, Takeda K, Akira S. (2002) Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway.. Nat Immunol, 3 (2): (196-200). [PMID:11812998]
2. Jurk M, Heil F, Vollmer J, Schetter C, Krieg AM, Wagner H, Lipford G, Bauer S. (2002) Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848.. Nat Immunol, 3 (6): (499). [PMID:12032557]
3. Stockfleth E, Hofbauer GFL, Reinhold U, Popp G, Hengge UR, Szeimies RM, Brüning H, Anliker M, Hunger T, Dummer R et al.. (2019) Topical resiquimod dosing regimens in patients with multiple actinic keratoses: a multicentre, partly placebo-controlled, double-blind clinical trial.. Br J Dermatol, 180 (2): (297-305). [PMID:30171698]

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