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Home Bioactive Small Molecules Resiquimod - 10mM in DMSO, high purity , Toll-like receptor 7 agonist, CAS No.144875-48-9(DMSO), Toll-like receptor 7 agonist
Resiquimod - 10mM in DMSO, high purity , Toll-like receptor 7 agonist, CAS No.144875-48-9(DMSO), Toll-like receptor 7 agonist
Toll-like receptor 7 (TLR7) agonist
Basic Description Synonyms Resiquimod | 144875-48-9 | 1-(4-Amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol | R-848 | 1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol | Resiquimod [INN] | R 848 | R848 | S-28463 | Resiquimod (GMP) | S 28463 | V3DMU Specifications & Purity Moligand™, 10mM in DMSO Biochemical and Physiological Mechanisms Toll-like receptor 7 (TLR7) agonist. Induces upregulation of IL-6, IL-12, IFN-γand iNOS expression in mouse bone marrow-derived macrophages (BMMs). Inhibits RANKL-induced osteoclast differentiation in mouse BMMs and human peripheral blood monocytes. Also Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type AGONIST Mechanism of action Toll-like receptor 7 agonist
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 1-[4-amino-2-(ethoxymethyl)imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol INCHI InChI=1S/C17H22N4O2/c1-4-23-9-13-20-14-15(21(13)10-17(2,3)22)11-7-5-6-8-12(11)19-16(14)18/h5-8,22H,4,9-10H2,1-3H3,(H2,18,19) InChi Key BXNMTOQRYBFHNZ-UHFFFAOYSA-N Canonical SMILES CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N Isomeric SMILES CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N WGK Germany 3 RTECS NJ5911320 PubChem CID 159603 Molecular Weight 314.38
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 31.44, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 15.72, Max Conc. mM: 50 Sensitivity Moisture sensitive；Heat sensitive Melt Point(°C) 193℃
Safety and Hazards(GHS) WGK Germany 3 RTECS NJ5911320
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