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Resolvin D1 - A solution in ethanol,≥95%, high purity , CAS No.872993-05-0, Agonist of FPR2/ALX;Agonist of GPR32;Gating inhibitor of TRPA1

Moligand™
≥95%
A solution in ethanol

CAS#: 872993-05-0
Formula: C₂₂H₃₂O₅
Molecular Weight: 376.5
PubChem CID: 53394122

Item Number

R341442

Grouped product items
SKU	Size	Availability	Price	Qty
R341442-10μg	10μg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$539.90

an anti-inflammatory that reduces human polymorphonuclear leukocyte transendothelial migration

View related series

FPR2/ALX Agonist GPR32 Agonist TRPA1 Gating inhibitor

Basic Description

Synonyms	17(R)-Resolvin D1\|SB48260\|RvD1\|Resolvin D1\|7,8,17-TRIHYDROXYDOCOSA-4,9,11,13,15,19-HEXAENOIC ACID\|17(R)-RvD1\|DTXSID60694000
Specifications & Purity	Moligand™, ≥95%, A solution in ethanol
Storage Temp	Protected from light,Store at -80°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST, GATING INHIBITOR
Mechanism of action	Agonist of FPR2/ALX;Agonist of GPR32;Gating inhibitor of TRPA1
Product Description	Resolvin D1 is from a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA) and docosahexaenoic (DHA)(1), it is an anti-inflammatory and promotes the resolution of the inflammatory response back to a non-inflamed state.2 RvD1 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase. It reduces human polymorphonuclear leukocyte (PMNL) transendothelial migration, the earliest event in acute inflammation, with EC50 values of ~30 nM. It exhibits a dose-dependent reduction in leukocyte infiltration in a murine model of peritonitis with a maximal inhibition of ~35% at a 10-100 ng dose. Resolvin D1 (RvD1) is supplied as a solution in ethanol. To change the solvent, simply evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice. It is recommended that this product be stored and handled in an ethanol solution. Resolvins can isomerize and degrade when put into freeze thaw conditions and/or in solvents such as dimethyl formamide or DMSO.

Associated Targets

GPR32 Tchem Probable G-protein coupled receptor 32 1 Activities

Discover Target: GPR32

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FPR2 Tchem N-formyl peptide receptor 2 1 Activities

Discover Target: FPR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPA1 Tclin Transient receptor potential cation channel subfamily A member 1 1 Activities

Discover Target: TRPA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	7,8,17-trihydroxydocosa-4,9,11,13,15,19-hexaenoic acid
INCHI	InChI=1S/C22H32O5/c1-2-3-9-14-19(23)15-10-6-4-5-7-11-16-20(24)21(25)17-12-8-13-18-22(26)27/h3-12,15-16,19-21,23-25H,2,13-14,17-18H2,1H3,(H,26,27)
InChi Key	OIWTWACQMDFHJG-UHFFFAOYSA-N
Canonical SMILES	CCC=CCC(C=CC=CC=CC=CC(C(CC=CCCC(=O)O)O)O)O
Isomeric SMILES	CCC=CCC(C=CC=CC=CC=CC(C(CC=CCCC(=O)O)O)O)O
PubChem CID	53394122
Molecular Weight	376.5

CAS Registry No.

872993-05-0

PubChem CID

73755062

GPCRdb Ligand

resolvin D1

Certificates

Certificate of Analysis(COA)

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4 results found

Lot Number	Certificate Type	Date	Item
H2422504	Certificate of Analysis	Aug 15, 2024	R341442
E2429501	Certificate of Analysis	Apr 23, 2024	R341442
H2309197	Certificate of Analysis	Jul 25, 2023	R341442
G2303071	Certificate of Analysis	Jun 09, 2023	R341442

Solubility

Soluble in water (0.05 mg/mL) at 25° C, PBS pH 7.2 (~0.05 mg/mL), DMSO (~50 mg/mL), DMF (~50 mg/mL), and ethanol.

Sensitivity

Light sensitive

Boil Point(°C)

78° C

References

1. Colby JK, Abdulnour RE, Sham HP, Dalli J, Colas RA, Winkler JW, Hellmann J, Wong B, Cui Y, El-Chemaly S et al.. (2016) Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Protective for Injured Epithelia.. Am J Pathol, 186 (7): (1801-1813). [PMID:27171898]
2. Zhang MJ, Sansbury BE, Hellmann J, Baker JF, Guo L, Parmer CM, Prenner JC, Conklin DJ, Bhatnagar A, Creager MA et al.. (2016) Resolvin D2 Enhances Postischemic Revascularization While Resolving Inflammation.. Circulation, 134 (9): (666-680). [PMID:27507404]
3. Codagnone M, Cianci E, Lamolinara A, Mari VC, Nespoli A, Isopi E, Mattoscio D, Arita M, Bragonzi A, Iezzi M et al.. (2018) Resolvin D1 enhances the resolution of lung inflammation caused by long-term Pseudomonas aeruginosa infection.. Mucosal Immunol, 11 (1): (35-49). [PMID:28422188]

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