Basic Description

Synonyms	Retapamulin\|224452-66-8\|Altabax\|Altargo\|SB-275833\|SB 275833\|SB275833\|Rebapamulin\|4MG6O8991R\|NSC-759885\|[(1S,2R,3S,4S,6R,7R,8R,14R)-4-ethenyl-3-hydroxy-2,4,7,14-tetramethyl-9-oxo-6-tricyclo[5.4.3.01,8]tetradecanyl] 2-[[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]o
Specifications & Purity	Moligand™, ≥99%
Biochemical and Physiological Mechanisms	Retapamulin(SB-275833) is a topical antibiotic developed by GlaxoSmithKline. Retapamulin(SB-275833) is the first drug in the new class of pleuromutilin antibiotics to be approved for human use.Retapamulin(SB-275833) is marketed as an ointment under the br
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	70S ribosome inhibitor
Note	50mg卖完停产，不再备货
Product Description	Retapamulin is a topical antibiotic, which binds to both E. coli and S. aureus ribosomes with similar potencies with Kd of 3 nM. A broad spectrum antibiotic with no cross resistance to existing classes

Product Properties

ALogP	6.1

Associated Targets

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	[(1S,2R,3S,4S,6R,7R,8R,14R)-4-ethenyl-3-hydroxy-2,4,7,14-tetramethyl-9-oxo-6-tricyclo[5.4.3.01,8]tetradecanyl] 2-[[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]sulfanyl]acetate
INCHI	InChI=1S/C30H47NO4S/c1-7-28(4)16-24(35-25(33)17-36-22-14-20-8-9-21(15-22)31(20)6)29(5)18(2)10-12-30(19(3)27(28)34)13-11-23(32)26(29)30/h7,18-22,24,26-27,34H,1,8-17H2,2-6H3/t18-,19+,20-,21+,22?,24-,26+,27+,28-,29+,30+/m1/s1
InChi Key	STZYTFJPGGDRJD-FJJJPKKESA-N
Canonical SMILES	CC1CCC23CCC(=O)C2C1(C(CC(C(C3C)O)(C)C=C)OC(=O)CSC4CC5CCC(C4)N5C)C
Isomeric SMILES	C[C@@H]1CC[C@@]23CCC(=O)[C@H]2[C@@]1([C@@H](C[C@@]([C@H]([C@@H]3C)O)(C)C=C)OC(=O)CSC4C[C@H]5CC[C@@H](C4)N5C)C
PubChem CID	6918462
Molecular Weight	517.76

Database links

PubChem CID	6918462
CAS Registry No.	224452-66-8
Antibiotic DB	1994

Certificates

Certificate of Analysis(COA)

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7 results found

Lot Number	Certificate Type	Date	Item
K2211618	Certificate of Analysis	Aug 22, 2024	R125875
K2211621	Certificate of Analysis	Aug 22, 2024	R125875
K2211723	Certificate of Analysis	Aug 22, 2024	R125875
A2419558	Certificate of Analysis	Nov 20, 2023	R125875
A2419579	Certificate of Analysis	Nov 20, 2023	R125875
A2419580	Certificate of Analysis	Nov 20, 2023	R125875
A2419586	Certificate of Analysis	Nov 20, 2023	R125875

Chemical and Physical Properties

Solubility	DMSO 104 mg/mL ;Water <1 mg/mL;Ethanol 104 mg/mL

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H412:Harmful to aquatic life with long lasting effects H302:Harmful if swallowed H312:Harmful in contact with skin
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

References

1. Traczewski MM, Brown SD. (2008) Proposed MIC and disk diffusion microbiological cutoffs and spectrum of activity of retapamulin, a novel topical antimicrobial agent.. Antimicrob Agents Chemother, 52 (11): (3863-7). [PMID:18725451]

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SKU	Size	Availability	Price
R125875-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$19.90
R125875-250mg	250mg	In stock	$45.90
R125875-1g	1g	In stock	$119.90
R125875-5g	5g	In stock	$359.90

Retapamulin - ≥99%, high purity , 70S ribosome inhibitor, CAS No.224452-66-8, 70S ribosome inhibitor