Skip to the beginning of the images gallery

retaspimycin hydrochloride , Heat shock protein HSP90 inhibitor, CAS No.R613160, Heat shock protein HSP90 inhibitor

Moligand™

PubChem CID: 11685945

Item Number

R613160

Grouped product items
SKU	Size	Availability	Price	Qty
R613160-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
R613160-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

View related series

heat shock protein 90 alpha family class A member 1 Inhibitor

Basic Description

Synonyms	retaspimycin hydrochloride\|Retaspimycin HCl\|IPI-504\|857402-63-2\|IPI-504 HYDROCHLORIDE\|CHEBI:71956\|IPI 504\|Retaspimycin hydrochloride [USAN]\|Retaspimycin (Hydrochloride)\|928Q33Q049\|857402-63-2 (HCl)\|[(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6,20,22-trihydroxy-5,11
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Heat shock protein HSP90 inhibitor

Associated Targets

HSP90B1 Tchem Endoplasmin 0 Activities

Discover Target: HSP90B1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HSP90AA1 Tchem Heat shock protein HSP 90-alpha 1 Activities

Discover Target: HSP90AA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDGFRA Tclin Platelet-derived growth factor receptor alpha 0 Activities

Discover Target: PDGFRA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	[(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6,20,22-trihydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16-oxo-21-(prop-2-enylamino)-17-azabicyclo[16.3.1]docosa-1(22),8,12,14,18,20-hexaen-10-yl] carbamate;hydrochloride
INCHI	InChI=1S/C31H45N3O8.ClH/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35;/h8-11,15-17,19,24-25,27,29,33,35-37H,1,12-14H2,2-7H3,(H2,32,39)(H,34,38);1H/b11-9-,18-10+,20-15+;/t17-,19+,24+,25+,27-,29+;/m1./s1
InChi Key	OIRUWDYJGMHDHJ-AFXVCOSJSA-N
Canonical SMILES	C=CCNc1c(O)cc2c(c1C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(\C)/[C@@H]([C@H](/C=C\C=C(\C(=O)N2)/C)OC)OC(=O)N)O.Cl
Isomeric SMILES	C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=C\C=C(\C(=O)NC2=CC(=C(C(=C2O)C1)NCC=C)O)/C)OC)OC(=O)N)\C)C)O)OC.Cl
PubChem CID	11685945

PubChem CID

11685945

Reactome Reaction

R-HSA-1218824

Reactome Drug

R-ALL-1217514

References

1. Ge J, Normant E, Porter JR, Ali JA, Dembski MS, Gao Y, Georges AT, Grenier L, Pak RH, Patterson J et al.. (2006) Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.. J Med Chem, 49 (15): (4606-15). [PMID:16854066]
2. Wagner AJ, Chugh R, Rosen LS, Morgan JA, George S, Gordon M, Dunbar J, Normant E, Grayzel D, Demetri GD. (2013) A phase I study of the HSP90 inhibitor retaspimycin hydrochloride (IPI-504) in patients with gastrointestinal stromal tumors or soft-tissue sarcomas.. Clin Cancer Res, 19 (21): (6020-9). [PMID:24045182]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

retaspimycin hydrochloride , Heat shock protein HSP90 inhibitor, CAS No.R613160, Heat shock protein HSP90 inhibitor

Basic Description

Associated Targets

HSP90B1 Tchem Endoplasmin 0 Activities

HSP90AA1 Tchem Heat shock protein HSP 90-alpha 1 Activities

PDGFRA Tclin Platelet-derived growth factor receptor alpha 0 Activities

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Related Documents

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator