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Transmembrane Transporters
Voltage-gated ion channels
Potassium channels
retigabine derivative 10g , CAS No.R613161, Activator of K v7.4;Activator of K v7.5

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retigabine derivative 10g , CAS No.R613161, Activator of K v7.4;Activator of K v7.5

Moligand™

PubChem CID: 155567226

Item Number

R613161

Grouped product items
SKU	Size	Availability	Price	Qty
R613161-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
R613161-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

Kv7.4 Activator Kv7.5 Activator

Basic Description

Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	ACTIVATOR
Mechanism of action	Activator of K v7.4;Activator of K v7.5

Associated Targets(Human)

KCNQ4 Tclin Potassium voltage-gated channel subfamily KQT member 4 (1 Activities)

Discover Target: KCNQ4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNQ5 Tclin Potassium voltage-gated channel subfamily KQT member 5 (1 Activities)

Discover Target: KCNQ5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNQ4 Tclin Voltage-gated potassium channel subunit Kv7.4 (100 Activities)

Discover Target: KCNQ4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KCNQ5 Tclin Voltage-gated potassium channel subunit Kv7.5 (49 Activities)

Discover Target: KCNQ5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KCNQ3 Tclin Voltage-gated potassium channel subunit Kv7.3 (20 Activities)

Discover Target: KCNQ3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Kcnq2 Voltage-gated potassium channel subunit Kv7.2 (95 Activities)

Discover Target: Kcnq2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	tert-butyl N-[2-(ethoxycarbonylamino)-5-[(4-fluorophenyl)methyl-prop-2-ynylamino]phenyl]carbamate
INCHI	InChI=1S/C24H28FN3O4/c1-6-14-28(16-17-8-10-18(25)11-9-17)19-12-13-20(26-22(29)31-7-2)21(15-19)27-23(30)32-24(3,4)5/h1,8-13,15H,7,14,16H2,2-5H3,(H,26,29)(H,27,30)
InChi Key	FWQHRZXEQNUCSY-UHFFFAOYSA-N
Canonical SMILES	CCOC(=O)Nc1ccc(cc1NC(=O)OC(C)(C)C)N(Cc1ccc(cc1)F)CC#C
Isomeric SMILES	CCOC(=O)NC1=C(C=C(C=C1)N(CC#C)CC2=CC=C(C=C2)F)NC(=O)OC(C)(C)C
PubChem CID	155567226

Database links

PubChem CID	155567226
ChEMBL Ligand	CHEMBL4588394
BindingDB Ligand	50521289

Certificates

Certificate of Analysis(COA)

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References

1. Wang L, Qiao GH, Hu HN, Gao ZB, Nan FJ. (2019) Discovery of Novel Retigabine Derivatives as Potent KCNQ4 and KCNQ5 Channel Agonists with Improved Specificity.. ACS Med Chem Lett, 10 (1): (27-33). [PMID:30655942] [10.1021/op500134e]

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