Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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R106321-250mg | 250mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $206.90 |
Synonyms | (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid | TRETINOIN COMPONENT OF ZIANA | Tretinoina (INN-Spanish) | Avita (0.025% gel) | Retinoate | Tretinoina [INN-Spanish] | b-Retinoic acid | Tretinoin [USAN:USP:INN: |
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Specifications & Purity | Moligand™, analytical standard |
Biochemical and Physiological Mechanisms | Description: IC50 Value: N/A All-trans retinoic acid (ATRA) has been widely investigated for treatments of many cancers including prostate cancer. in vitro: ATRA was able to induce the growth arrest and to increase HOXB13 expression in AR |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | analytical standard, Moligand™ |
Action Type | AGONIST, ANTAGONIST |
Mechanism of action | Retinoic acid receptor agonist |
ALogP | 6.3 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid |
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INCHI | InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+ |
InChi Key | SHGAZHPCJJPHSC-YCNIQYBTSA-N |
Canonical SMILES | CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C |
Isomeric SMILES | CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/C(=O)O)/C)/C |
WGK Germany | 2 |
RTECS | VH6475000 |
PubChem CID | 444795 |
Molecular Weight | 300.44 |
Beilstein | 2057223 |
Reaxy-Rn | 2057223 |
Enter Lot Number to search for COA:
Melt Point(°C) | 180-181°C |
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Pictogram(s) | GHS08, GHS07 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H360:May damage fertility or the unborn child |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 2 |
RTECS | VH6475000 |
Reaxy-Rn | 2057223 |
Merck Index | 8165 |
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18. Hang Hu, Defeng Xu. (2021) Co-delivery of docetaxel and retinoic acid by poly (ethylene glycol)-retinoic acid conjugates based micelles for synergistic prostate cancer therapy. Micro & Nano Letters, 16 (6): (336-343). [PMID:] |
19. Jiang Ying, Song Hanbing, Jiang Ling, Qiao Yu, Yang Dan, Wang Donghua, Li Ji. (2020) Silybin Prevents Prostate Cancer by Inhibited the ALDH1A1 Expression in the Retinol Metabolism Pathway. Frontiers in Cell and Developmental Biology, 8 (888). [PMID:32984354] |
20. Ken Zhao, Jie Liu, Gang Dong, Huan Xia, Pingan Wang, Xuan Xiao, Zhen Chen. (2020) Preliminary research on the effects and mechanisms of umbilical cord‑derived mesenchymal stem cells in streptozotocin‑induced diabetic retinopathy Corrigendum in /10.3892/ijmm.2020.4708. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 46 (2): (849-858). [PMID:32626946] |
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22. Hu Hang, Wang Chong, Zhang Rong, Xiao Chen, Lai Chao, Li Zifu, Xu Defeng. (2020) Branched worm-like nanoparticles featured with programmed drug release for synergistic castration-resistant prostate cancer therapy. JOURNAL OF MATERIALS SCIENCE, 55 (16): (6992-7008). [PMID:] |
23. Song Lin, Yao Lifen, Zhang Limei, Piao Zhongyuan, Lu Yichan. (2020) Schizandrol A protects against Aβ1–42-induced autophagy via activation of PI3K/AKT/mTOR pathway in SH-SY5Y cells and primary hippocampal neurons. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 393 (9): (1739-1752). [PMID:31900522] |
24. Qing-qing Xia, Ling-min Zhang, Ying-ying Zhou, Ya-lin Wu, Jie Li. (2019) All-trans-retinoic acid generation is an antidotal clearance pathway for all-trans-retinal in the retina. Journal of Zhejiang University-SCIENCE B, 20 (12): ( 960–971). [PMID:31749343] |
25. Chao Guo, Junrong Zhu, Jingwen Wang, Jialin Duan, Shanbo Ma, Ying Yin, Wei Quan, Wei Zhang, Yue Guan, Yi Ding, Aidong Wen, Yingdong Zhang. (2019) Neuroprotective effects of protocatechuic aldehyde through PLK2/p-GSK3β/Nrf2 signaling pathway in both in vivo and in vitro models of Parkinson's disease. Aging-US, 11 (21): ( 9424–9441). [PMID:31697645] |
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27. Lumei Chi, Dan Jiao, Guangxian Nan, Honghua Yuan, Jing Shen, Yu Gao. (2019) miR-9-5p attenuates ischemic stroke through targeting ERMP1-mediated endoplasmic reticulum stress. ACTA HISTOCHEMICA, 121 (151438). [PMID:31500865] |
28. Cui Huang, Jing Ma, Bai‑Xiang Li, Yan Sun. (2019) Wnt1 silencing enhances neurotoxicity induced by paraquat and maneb in SH‑SY5Y cells. Experimental and Therapeutic Medicine, 18 (5): (3643-3649). [PMID:31602242] |
29. Tingting Luo, Jingtian Han, Feng Zhao, Xiaohong Pan, Baocheng Tian, Xiujuan Ding, Jing Zhang. (2019) Redox-sensitive micelles based on retinoic acid modified chitosan conjugate for intracellular drug delivery and smart drug release in cancer therapy. CARBOHYDRATE POLYMERS, 215 (8). [PMID:30981373] |
30. Yanqiu Zhang, Lianjun Peng, Jiahui Chu, Ming Zhang, Lizhu Sun, Bin Zhong, Qiyong Wu. (2018) pH and redox dual-responsive copolymer micelles with surface charge reversal for co-delivery of all-trans-retinoic acid and paclitaxel for cancer combination chemotherapy. International Journal of Nanomedicine, [PMID:30410335] |
31. Jia Jiao, Hongshuai Wu, Fanghui Chen, Renjie Chen, Baiwang Sun, Mingliang Wang. (2018) Delivery of coumarin-containing all-trans retinoic acid derivatives via targeted nanoparticles encapsulating indocyanine green for chemo/photothermal/photodynamic therapy of breast cancer. NEW JOURNAL OF CHEMISTRY, 42 (11): (8805-8814). [PMID:] |
32. Yuming Yang, Caixia Yue, Yu Han, Wei Zhang, Aina He, Chunlei Zhang, Ting Yin, Qian Zhang, Jingjing Zhang, Yao Yang, Jian Ni, Jielin Sun, Daxiang Cui. (2016) Tumor-Responsive Small Molecule Self-Assembled Nanosystem for Simultaneous Fluorescence Imaging and Chemotherapy of Lung Cancer. ADVANCED FUNCTIONAL MATERIALS, 26 (47): (8735-8745). [PMID:] |
33. Jing Zhang, Jian Han, Xiuli Zhang, Jing Jiang, Maolei Xu, Daolai Zhang, Jingtian Han. (2015) Polymeric nanoparticles based on chitooligosaccharide as drug carriers for co-delivery of all-trans-retinoic acid and paclitaxel. CARBOHYDRATE POLYMERS, 129 (25). [PMID:26050884] |
34. Juan Yang, Nana Wu, Jie Peng, Xiaoquan Yang, Jian Guo, Shouwei Yin, Jinmei Wang. (2015) Prevention of retinoic acid-induced osteoporosis in mice by isoflavone-enriched soy protein. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 96 (1): (331-338). [PMID:25645024] |
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