Reveromycin B - >90%, high purity , CAS No.144860-68-4

  • ≥90%
Item Number
R329692
Grouped product items
SKUSizeAvailabilityPrice Qty
R329692-250μg
250μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$370.90

a novel polyketide type antibiotic shown inhibit mitogenic activity

Basic Description

Specifications & Purity≥90%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Product Description

Reveromycin B is a novel polyketide type antibiotic reveromycin B is a much less active analogue of reveromycin A formed by rearrangement of the 6:6 spiroketal to a 5:6 spiroketal. Lacking much of the biological activity of reveromycin A, reveromycin B is a useful negative control in resolving the mode of action of this class. It has shown to be an inhibitor of the mitogenic activity of epidermal growth factor.

Product Properties

pKapKₐ: 4.31 (Predicted)

Associated Targets(non-human)

ileS Isoleucyl-tRNA synthetase (49 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NRK (373 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name (2E,4S,5S,6E,8E)-10-[(2R,5S,8S,9R)-2-butyl-2-[(1S,2E,4E)-5-carboxy-1-(3-carboxypropanoyloxy)-4-methylpenta-2,4-dienyl]-8-methyl-1,10-dioxaspiro[4.5]decan-9-yl]-5-hydroxy-4,8-dimethyldeca-2,6,8-trienoic acid
INCHI InChI=1S/C36H52O11/c1-6-7-19-35(30(14-10-25(3)23-33(42)43)45-34(44)17-16-32(40)41)21-22-36(47-35)20-18-27(5)29(46-36)13-9-24(2)8-12-28(37)26(4)11-15-31(38)39/h8-12,14-15,23,26-30,37H,6-7,13,16-22H2,1-5H3,(H,38,39)(H,40,41)(H,42,43)/b12-8+,14-10+,15-11+,24-9+,25-23+/t26-,27-,28-,29+,30-,35+,36-/m0/s1
InChi Key XVFQIVPMOPJEIO-OXVOKJAASA-N
Canonical SMILES CCCCC1(CCC2(O1)CCC(C(O2)CC=C(C)C=CC(C(C)C=CC(=O)O)O)C)C(C=CC(=CC(=O)O)C)OC(=O)CCC(=O)O
Isomeric SMILES CCCC[C@@]1(CC[C@@]2(O1)CC[C@@H]([C@H](O2)C/C=C(\C)/C=C/[C@@H]([C@@H](C)/C=C/C(=O)O)O)C)[C@H](/C=C/C(=C/C(=O)O)/C)OC(=O)CCC(=O)O
PubChem CID 10865248
Molecular Weight 660.8

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySoluble in ethyl acetate, ethanol, methanol, DMF, and DMSO.
Refractive Indexn20D1.56 (Predicted)
Boil Point(°C)848.97° C at 760 mmHg (Predicted)

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Solution Calculators