RG108 is a non-nucleoside DNA methyltransferase (Dnmt) inhibitor that blocks the enzyme active site. RG108 inhibits DNA methylation in human cancer cell lines without detectable toxicity in vitro. The compound demethylates and reactivates epigenetically s
Storage Temp
Protected from light,Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
RG108 is an inhibitor of DNA methyltransferase with IC50 of 115 nM, does not cause trapping of covalent enzymes. A Dnmt inhibitor that silences tumor suppressor genes.
Associated Targets(Human)
DNMT3BTchem DNA (cytosine-5)-methyltransferase 3B 1 Activities
1.Liu K et al.. (2020) DNA Methylation May be Involved in the Analgesic Effect of Hyperbaric Oxygen via Regulating FUNDC1.. Pain Res Manag, 2020 (1528362). [PMID:32148597]
2.Bialesova L et al.. (2017) Epigenetic Regulation of PLIN 1 in Obese Women and its Relation to Lipolysis.. Sci Rep, 7 (10152). [PMID:28860604]
3.Saunders J et al.. (2018) Negative Evidence for a Functional Role of Neuronal DNMT3a in Persistent Pain.. Front Mol Neurosci, 11 (332). [PMID:30258352]
4.Zanconato F et al.. (2018) Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4.. Nat Med, 24 (10):(1599-1610). [PMID:30224758]
Solution Calculators
Molarity Calculator
Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator
Determine the dilution needed to prepare a stock solution.
H2222097