Click Here for 5% Off Your First Aladdin Purchase!
Call +1 (833) 552-7181 or Contact us Earn $25 in coupons on your first order with Aladdin!
Toggle Nav
My Cart
Search
Advanced Search
Menu
Sign In
྾
main product photo

RG108 - ≥98%, high purity , CAS No.48208-26-0

  • ≥98%
Item Number
R126814
Grouped product items
SKUSizeAvailabilityPrice Qty
R126814-10mg
10mg
In stock
$77.90
R126814-50mg
50mg
In stock
$260.90
R126814-250mg
250mg
In stock
$1,174.90
R126814-1g
1g
In stock
$4,228.90
Add to Wish List Compare
Bulk Order  SDS  DATASHEET

Discover RG108 by Aladdin Scientific in ≥98% for only $77.90. Available - in Ligands at Aladdin Scientific. Novel, non-nucleoside DNA methyltransferase inhibitor (DNMT) Tags: azole, Five-Membered Heterocyclic Compounds.

View related series
azole Five-Membered Heterocyclic Compounds

Basic Description

SynonymsRG108|48208-26-0|N-Phthalyl-L-tryptophan|RG 108|RG-108|(S)-2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid|CHEMBL1564869|(S)-2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid.|NSC-401077|(2S)-2-(1,3-dioxoisoindol-2-yl)-3-(1H-indol-
Specifications & Purity≥98%
Storage TempProtected from light,Store at -20°C,Argon charged
Shipped InDry ice
Product Description

RG108 is an inhibitor of DNA methyltransferase with IC50 of 115 nM, does not cause trapping of covalent enzymes.
A Dnmt inhibitor that silences tumor suppressor genes.

Associated Targets

DNMT3B Tchem DNA (cytosine-5)-methyltransferase 3B 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

DNMT1 Tclin DNA (cytosine-5)-methyltransferase 1 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name (2S)-2-(1,3-dioxoisoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid
INCHI InChI=1S/C19H14N2O4/c22-17-13-6-1-2-7-14(13)18(23)21(17)16(19(24)25)9-11-10-20-15-8-4-3-5-12(11)15/h1-8,10,16,20H,9H2,(H,24,25)/t16-/m0/s1
InChi Key HPTXLHAHLXOAKV-INIZCTEOSA-N
Canonical SMILES C1=CC=C2C(=C1)C(=O)N(C2=O)C(CC3=CNC4=CC=CC=C43)C(=O)O
Isomeric SMILES C1=CC=C2C(=C1)C(=O)N(C2=O)[C@@H](CC3=CNC4=CC=CC=C43)C(=O)O
WGK Germany 3
PubChem CID 702558
Molecular Weight 334.33
Reaxy-Rn 4552782

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

12 results found

Lot NumberCertificate TypeDateItem
H2222097Certificate of AnalysisJun 20, 2024 R126814
H2222100Certificate of AnalysisJun 20, 2024 R126814
G2312550Certificate of AnalysisJun 16, 2023 R126814
G2312554Certificate of AnalysisJun 16, 2023 R126814
G2312556Certificate of AnalysisJun 16, 2023 R126814
G2312621Certificate of AnalysisJun 16, 2023 R126814
G2312627Certificate of AnalysisJun 16, 2023 R126814
G2312639Certificate of AnalysisJun 16, 2023 R126814
G2312640Certificate of AnalysisJun 16, 2023 R126814
G2312682Certificate of AnalysisJun 16, 2023 R126814
F1503110Certificate of AnalysisJan 25, 2023 R126814
H2222105Certificate of AnalysisJun 20, 2022 R126814

more

Chemical and Physical Properties

SolubilitySoluble in DMSO (100 mM), water (<1 mg/ml at 25 °C), ethanol (67 mg/ml at 25 °C), and DMF (~30 mg/ml).
Sensitivityheat sensitive;light sensitive
Specific Rotation[α]-271° (C=1,EtOH)
Melt Point(°C)181 °C

Safety and Hazards(GHS)

WGK Germany 3
Reaxy-Rn 4552782

Related Documents

 SDS

 Specification Sheet

Alternative Products

  1. RG108 - 10mM in DMSO, used for , CAS No. 48208-26-0(DMSO), by Aladdin Scientific
    RG108

    Starting at $181.90

References

1. Liu K et al..  (2020)  DNA Methylation May be Involved in the Analgesic Effect of Hyperbaric Oxygen via Regulating FUNDC1..  Pain Res Manag,  2020  (1528362).  [PMID:32148597]
2. Bialesova L et al..  (2017)  Epigenetic Regulation of PLIN 1 in Obese Women and its Relation to Lipolysis..  Sci Rep,  7  (10152).  [PMID:28860604]
3. Saunders J et al..  (2018)  Negative Evidence for a Functional Role of Neuronal DNMT3a in Persistent Pain..  Front Mol Neurosci,  11  (332).  [PMID:30258352]
4. Zanconato F et al..  (2018)  Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4..  Nat Med,  24  (10): (1599-1610).  [PMID:30224758]

Solution Calculators

Privacy Policy Website Terms of Use Return policy Terms and Conditions of Sale Cookie Policy Sales Policy
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
Copyright © 2023-present Aladdin Scientific Corp . All rights reserved.