RG108 - 10mM in DMSO, high purity , CAS No.48208-26-0(DMSO)

  • 10mM in DMSO
Item Number
R408948
Grouped product items
SKUSizeAvailabilityPrice Qty
R408948-1ml
1ml
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$181.90

DNA Methyltransferase Inhibitors

Basic Description

Specifications & Purity10mM in DMSO
Storage TempStore at -80°C
Shipped InIce chest + Ice pads
Product Description

Information

RG108 RG108 (N-Phthalyl-L-tryptophan) is an inhibitor of DNA methyltransferase with IC50 of 115 nM in a cell-free assay, does not cause trapping of covalent enzymes.
In vitro

RG108 effectively blocks DNA methyltransferases in vitro and does not cause covalent enzyme trapping in human cell lines. Incubation of cells with low micromolar concentrations of RG108 results in significant demethylation of genomic DNA without any detectable toxicity. Intriguingly, RG108 causes demethylation and reactivation of tumor suppressor genes, but it does not affect the methylation of centromeric satellite sequences. In another study, the synthesis and in vitro analysis of a biotinylated RG108 conjugate is investigated to evaluate the interactions with DNA methyltransferase enzymes. In a recent study, it is shown RG108 can significantly reduce the DNA methyltransferases activity in SM derived iPS cells as compared to the native SMs.

In vivo


Cell Data

cell lines:

Concentrations:1-100 μM

Incubation Time:5 days

Powder Purity:≥99%

Associated Targets(Human)

DNMT3B Tchem DNA (cytosine-5)-methyltransferase 3B 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

DNMT1 Tclin DNA (cytosine-5)-methyltransferase 1 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Canonical SMILES OC(=O)C(CC1=C[NH]C2=C1C=CC=C2)N3C(=O)C4=CC=CC=C4C3=O
Molecular Weight 334.33

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