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RG2833 - ≥98%, high purity , CAS No.1215493-56-3, Inhibitor of histone deacetylase 1;Inhibitor of histone deacetylase 3

  • Moligand™
  • ≥98%
Item Number
R127721
Grouped product items
SKUSizeAvailabilityPrice Qty
R127721-5mg
5mg
In stock
$58.90
R127721-10mg
10mg
In stock
$105.90
R127721-25mg
25mg
In stock
$127.90
R127721-50mg
50mg
In stock
$147.90
R127721-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$246.90
R127721-250mg
250mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$555.90

Basic Description

SynonymsRG2833|1215493-56-3|RG-2833|N-(6-((2-Aminophenyl)amino)-6-oxohexyl)-4-methylbenzamide|RGFP 109|RGFP-109|RGFP109|RG2833 (RGFP109)|N-(6-(2-Aminophenylamino)-6-oxohexyl)-4-methylbenzamide|17V14R89EU|N-[6-(2-aminoanilino)-6-oxohexyl]-4-methylbenzamide|N-[6-(2
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological Mechanisms Description: IC50 Value: N/A RGFP 109 is a histone deacetylase inhibitor which can attenuate L-DOPA-induced dyskinesia in the MPTP-lesioned marmoset. in vitro: N/A in vivo: RGFP109 had no acute effects on dyskinesia after single or 6 days once-daily trea
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of histone deacetylase 1;Inhibitor of histone deacetylase 3

Associated Targets

HDAC4 Tclin Histone deacetylase 4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC1 Tclin Histone deacetylase 1 3 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC7 Tclin Histone deacetylase 7 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC2 Tclin Histone deacetylase 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

LTA4H Tchem Leukotriene A-4 hydrolase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC8 Tclin Histone deacetylase 8 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC5 Tclin Histone deacetylase 5 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC3 Tclin Histone deacetylase 3 3 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name N-[6-(2-aminoanilino)-6-oxohexyl]-4-methylbenzamide
INCHI InChI=1S/C20H25N3O2/c1-15-10-12-16(13-11-15)20(25)22-14-6-2-3-9-19(24)23-18-8-5-4-7-17(18)21/h4-5,7-8,10-13H,2-3,6,9,14,21H2,1H3,(H,22,25)(H,23,24)
InChi Key VOPDXHFYDJAYNS-UHFFFAOYSA-N
Canonical SMILES CC1=CC=C(C=C1)C(=O)NCCCCCC(=O)NC2=CC=CC=C2N
Isomeric SMILES CC1=CC=C(C=C1)C(=O)NCCCCCC(=O)NC2=CC=CC=C2N
PubChem CID 56654642
Molecular Weight 339.43

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

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6 results found

Lot NumberCertificate TypeDateItem
A2205348Certificate of AnalysisOct 10, 2023 R127721
A2205349Certificate of AnalysisOct 10, 2023 R127721
A2205350Certificate of AnalysisOct 10, 2023 R127721
A2205354Certificate of AnalysisOct 10, 2023 R127721
A2205359Certificate of AnalysisOct 10, 2023 R127721
A2205360Certificate of AnalysisOct 10, 2023 R127721

Chemical and Physical Properties

Solubility insoluble in H2O; ≥16.95 mg/mL in DMSO; ≥8.05 mg/mL in EtOH with gentle warming and ultrasonic

Related Documents

References

1. Rai M, Soragni E, Chou CJ, Barnes G, Jones S, Rusche JR, Gottesfeld JM, Pandolfo M.  (2010)  Two new pimelic diphenylamide HDAC inhibitors induce sustained frataxin upregulation in cells from Friedreich's ataxia patients and in a mouse model..  PLoS ONE,  (1): (e8825).  [PMID:20098685]

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