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RG2833 - ≥98%, high purity , CAS No.1215493-56-3, Inhibitor of histone deacetylase 1;Inhibitor of histone deacetylase 3

Item Number
R127721
Grouped product items
SKUSizeAvailabilityPrice Qty
R127721-5mg
5mg
In stock
$58.90
R127721-10mg
10mg
In stock
$105.90
R127721-25mg
25mg
In stock
$127.90
R127721-50mg
50mg
In stock
$147.90
R127721-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$246.90
R127721-250mg
250mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$555.90
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histone deacetylase 1 Inhibitor histone deacetylase 3 Inhibitor

Basic Description

SynonymsAS-55992 | FT-0700118 | AC-33034 | N-[6-(2-aminoanilino)-6-oxohexyl]-4-methylbenzamide | N-[6-(2-aminophenylamino)-6-oxohexyl]-4-methylbenzamide | RGFP 109 | BDBM207629 | AKOS030525997 | DTXSID20153300 | A13139 | N-(6-(2-Aminophenylamino)-6-oxohexyl)-4-me
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological Mechanisms Description: IC50 Value: N/A RGFP 109 is a histone deacetylase inhibitor which can attenuate L-DOPA-induced dyskinesia in the MPTP-lesioned marmoset. in vitro: N/A in vivo: RGFP109 had no acute effects on dyskinesia after single or 6 days once-daily trea
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of histone deacetylase 1;Inhibitor of histone deacetylase 3

Associated Targets(Human)

HDAC1 Tclin Histone deacetylase 1 (3 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HDAC3 Tclin Histone deacetylase 3 (3 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
LTA4H Tchem Leukotriene A4 hydrolase (1442 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HDAC8 Tclin Histone deacetylase 8 (4516 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HDAC2 Tclin Histone deacetylase 2 (3971 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HDAC3 Tclin Histone deacetylase 3 (3654 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HDAC4 Tclin Histone deacetylase 4 (2328 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HDAC7 Tclin Histone deacetylase 7 (1047 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HDAC3 Tclin Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) (735 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac1 Histone deacetylase 1 (93 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac5 Histone deacetylase 5 (5 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name N-[6-(2-aminoanilino)-6-oxohexyl]-4-methylbenzamide
INCHI InChI=1S/C20H25N3O2/c1-15-10-12-16(13-11-15)20(25)22-14-6-2-3-9-19(24)23-18-8-5-4-7-17(18)21/h4-5,7-8,10-13H,2-3,6,9,14,21H2,1H3,(H,22,25)(H,23,24)
InChi Key VOPDXHFYDJAYNS-UHFFFAOYSA-N
Canonical SMILES CC1=CC=C(C=C1)C(=O)NCCCCCC(=O)NC2=CC=CC=C2N
Isomeric SMILES CC1=CC=C(C=C1)C(=O)NCCCCCC(=O)NC2=CC=CC=C2N
PubChem CID 56654642
Molecular Weight 339.43

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

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6 results found

Lot NumberCertificate TypeDateItem
A2205348Certificate of AnalysisOct 10, 2023 R127721
A2205349Certificate of AnalysisOct 10, 2023 R127721
A2205350Certificate of AnalysisOct 10, 2023 R127721
A2205354Certificate of AnalysisOct 10, 2023 R127721
A2205359Certificate of AnalysisOct 10, 2023 R127721
A2205360Certificate of AnalysisOct 10, 2023 R127721

Chemical and Physical Properties

Solubility insoluble in H2O; ≥16.95 mg/mL in DMSO; ≥8.05 mg/mL in EtOH with gentle warming and ultrasonic

Related Documents

 SDS

 Specification Sheet

References

1. Rai M, Soragni E, Chou CJ, Barnes G, Jones S, Rusche JR, Gottesfeld JM, Pandolfo M.  (2010)  Two new pimelic diphenylamide HDAC inhibitors induce sustained frataxin upregulation in cells from Friedreich's ataxia patients and in a mouse model..  PLoS ONE,  5  (1): (e8825).  [PMID:20098685]

Solution Calculators

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