Determine the necessary mass, volume, or concentration for preparing a solution.
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Synonyms | Rhein | 478-43-3 | Monorhein | Rhubarb Yellow | Rheic acid | Cassic acid | 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid | 4,5-Dihydroxyanthraquinone-2-carboxylic acid | Chrysazin-3-carboxylic acid | 1,8-Dihydroxy-3-carboxyanthraquinone | Rheinic acid | NSC |
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Specifications & Purity | 10mM in DMSO |
Storage Temp | Store at -80°C |
Shipped In | Ice chest + Ice pads |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid |
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INCHI | InChI=1S/C15H8O6/c16-9-3-1-2-7-11(9)14(19)12-8(13(7)18)4-6(15(20)21)5-10(12)17/h1-5,16-17H,(H,20,21) |
InChi Key | FCDLCPWAQCPTKC-UHFFFAOYSA-N |
Canonical SMILES | C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)C(=O)O |
Isomeric SMILES | C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)C(=O)O |
WGK Germany | 2 |
RTECS | CA9516000 |
PubChem CID | 10168 |
Molecular Weight | 284.22 |
Beilstein | 2222155 |
Reaxy-Rn | 2222155 |
Enter Lot Number to search for COA:
Melt Point(°C) | 321-322°C |
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Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 2 |
RTECS | CA9516000 |
Reaxy-Rn | 2222155 |
Merck Index | 8176 |
1. Taorong Shen, Xing Huang, Yanfei Zhang, Yanli Tong, Yakun Shi, Jianhe Guo, Xiaoyong Zou, Yuzhi Xu, Zong Dai. (2023) Dephosphorylation Switch DNAzyme-RCA Circuit: A Robust Strategy for the Homogeneous and Reliable Detection of FTO Demethylase. ANALYTICAL CHEMISTRY, [PMID:38118402] [10.1021/acs.analchem.3c04762] |
2. Bi Wang, Jingjing Yang, Xingzeng Zhao, Xu Feng, Shu Xu, Pirui Li, Linwei Li, Yu Chen. (2023) Antifungal activity of the botanical compound rhein against Phytophthora capsici and the underlying mechanisms. PEST MANAGEMENT SCIENCE, (6): [PMID:37897133] [10.1002/ps.7852] |
3. Yan Zhou, Tian-Xiu Qiu, Huan Wang, Ling Hu, Lei Liu, Jiong Chen. (2023) Application of rhein as an immunostimulant controls spring viremia of carp virus infection. FISH & SHELLFISH IMMUNOLOGY, 142 (109128). [PMID:37777100] [10.1016/j.fsi.2023.109128] |
4. Rongkun Zhu, Zengcheng Du, Mingfang Zhu, Huanru Liang, Shumei Wang, Qing Zhou, Rui Li, Yulan Li, Chaoying Zeng, Wenhao Liu, Qiqing Chen. (2023) Molecularly imprinted polymers embedded with double perovskite quantum dots: A ratiometric fluorescence sensor for visible and fluorescent determination of Rhein. CHEMICAL ENGINEERING JOURNAL, 468 (143618). [PMID:] [10.1016/j.cej.2023.143618] |
5. Wan Li, Kexin Fang, Hao Yuan, Dongru Li, Haochen Li, Yin Chen, Xinyao Luo, Lian Zhang, Xiaochuan Ye. (2023) Acid-induced Poria cocos alkali-soluble polysaccharide hydrogel: Gelation behaviour, characteristics, and potential application in drug delivery. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 242 (124383). [PMID:37030457] [10.1016/j.ijbiomac.2023.124383] |
6. Lei Zhang, Ying-Xuan Liu, Ya-Ting Yao, Tian-Jiao Zhou, Hu-Lin Jiang, Cheng-jun Li. (2023) Injectable rhein-assisted crosslinked hydrogel for efficient local osteosarcoma chemotherapy. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 634 (122637). [PMID:36702387] [10.1016/j.ijpharm.2023.122637] |
7. Qing-Yun Hu, Junfeng Hu, Han Li, Xiaolin Fang, Zhi-Jun Sun, Zhigang Xu, Lu Zhang. (2022) Anti-inflammatory and antioxidant effects of rhein loaded nanomicelles in periodontitis. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 654 (130164). [PMID:] [10.1016/j.colsurfa.2022.130164] |
8. Yongjun Wu, Yong Xie, Hongwei Shi. (2022) Determination and Model Correlation of Rhein in 12 Pure Solvents from 283.15 K to 323.15 K. JOURNAL OF CHEMICAL AND ENGINEERING DATA, 67 (9): (2742–2748). [PMID:] [10.1021/acs.jced.2c00232] |
9. Yuanyuan Song, Ziqi Wang, Yijing Long, Yang Mao, Feng Jiang, Yuanyuan Lu. (2022) 2-Alkyl-anthraquinones inhibit Candida albicans biofilm via inhibiting the formation of matrix and hyphae. RESEARCH IN MICROBIOLOGY, 173 (103955). [PMID:35550403] [10.1016/j.resmic.2022.103955] |
10. Zhihui Yin, Demin Gao, Ke Du, Chen Han, Yuhan Liu, Ying Wang, Xiaoyan Gao. (2022) Rhein Ameliorates Cognitive Impairment in an APP/PS1 Transgenic Mouse Model of Alzheimer’s Disease by Relieving Oxidative Stress through Activating the SIRT1/PGC-1α Pathway. Oxidative Medicine and Cellular Longevity, 2022 (2524832). [PMID:35360200] [10.1155/2022/2524832] |
11. Rui Wang, Baifei Hu, Cheng Ye, Zhigang Zhang, Mingzhu Yin, Qiushi Cao, Yuanming Ba, Hongtao Liu. (2022) Stewed Rhubarb Decoction Ameliorates Adenine-Induced Chronic Renal Failure in Mice by Regulating Gut Microbiota Dysbiosis. Frontiers in Pharmacology, 13 (842720). [PMID:35392552] [10.3389/fphar.2022.842720] |
12. Ying Xu, Xuan Yu, Jiaqi Gui, Yiqun Wan, Jinping Chen, Ting Tan, Fan Liu, Lan Guo. (2022) Ultrasonic Solvent Extraction Followed by Dispersive Solid Phase Extraction (d-SPE) Cleanup for the Simultaneous Determination of Five Anthraquinones in Polygonum multiflorum by UHPLC-PDA. Foods, 11 (3): (386). [PMID:35159536] [10.3390/foods11030386] |
13. Yin Zhihui, Geng Xinyue, Zhang Zhengyi, Wang Ying, Gao Xiaoyan. (2021) Rhein Relieves Oxidative Stress in an Aβ1-42 Oligomer-Burdened Neuron Model by Activating the SIRT1/PGC-1α-Regulated Mitochondrial Biogenesis. Frontiers in Pharmacology, 12 (2481). [PMID:34566664] [10.3389/fphar.2021.746711] |
14. Jing Liang, Ke Min, Piao Long, Xuqian Weng, Qun Huang, Bo Chen, Ming Ma. (2021) Selective adsorption of flavonoids on cerium-doped ferroferric oxide magnetic particles. JOURNAL OF CHROMATOGRAPHY A, 1648 (462189). [PMID:33975082] [10.1016/j.chroma.2021.462189] |
15. Yan Zhang, Qing-nan Li, Kaiyue Zhou, Qinfeng Xu, Chun-yang Zhang. (2020) Identification of Specific N6-Methyladenosine RNA Demethylase FTO Inhibitors by Single-Quantum-Dot-Based FRET Nanosensors. ANALYTICAL CHEMISTRY, 92 (20): (13936–13944). [PMID:32972135] [10.1021/acs.analchem.0c02828] |
16. Sun Xu, Xu Li, Jiang Weina, Xuan Yan, Lu Wen, Li Zhong, Yang Shilong, Gu Zhenzhen. (2021) Adsorption mechanism of rhein-coated Fe3O4 as magnetic adsorbent based on low-field NMR. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 28 (1): (1052-1060). [PMID:32829435] [10.1007/s11356-020-10541-5] |
17. Yunchang Fan, Zeyu Niu, Chen Xu, Lei Yang, Tuojie Yang. (2019) Protic Ionic Liquids as Efficient Solvents in Microwave-Assisted Extraction of Rhein and Emodin from Rheum palmatum L.. MOLECULES, 24 (15): (2770). [PMID:31366111] [10.3390/molecules24152770] |
18. Qingqing Hao, Lilin Lu, Xianwen Kan. (2019) Probe and analogue: Double roles of thionine for aloe-emodin selective and sensitive ratiometric detection. SENSORS AND ACTUATORS B-CHEMICAL, 292 (247). [PMID:] [10.1016/j.snb.2019.04.129] |
19. Yang Lehe, Lin Shichong, Kang Yanting, Xiang Youqun, Xu Lingyuan, Li Jifa, Dai Xuanxuan, Liang Guang, Huang Xiaoying, Zhao Chengguang. (2019) Rhein sensitizes human pancreatic cancer cells to EGFR inhibitors by inhibiting STAT3 pathway. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 38 (1): (1-13). [PMID:30674340] [10.1186/s13046-018-1015-9] |
20. Pin Lv, Manshuo Liu, Rongqiang Liao, Yulin Zhao, Xiali Liao, Chuanzhu Gao, Bo Yang. (2017) Host–guest inclusion system of rhein with polyamine-modified β-cyclodextrins: characterization and cytotoxicity. PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, [PMID:27499262] [10.1080/10837450.2016.1221429] |
21. Xiaoya Jiang, Xiaoyan Jiao, Doudou Zhang, Ligai Bai, Haiyan Liu, Hongyuan Yan. (2017) Fabrication of a polymer monolithic column via redox system and its application in efficient separation of Chinese herb Rheum palmatum L.. JOURNAL OF APPLIED POLYMER SCIENCE, 134 (21): [PMID:] [10.1002/app.44874] |
22. Dong Jian-Wei, Cai Le, Fang Yun-Shan, Duan Wei-He, Li Zhen-Jie, Ding Zhong-Tao. (2016) Simultaneous, Simple and Rapid Determination of Five Bioactive Free Anthraquinones in Radix et Rhizoma Rhei by Quantitative 1H NMR. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 27 (11): (2120-2126). [PMID:] [10.5935/0103-5053.20160103] |
23. Manshuo Liu, Pin Lv, Rongqiang Liao, Yulin Zhao, Bo Yang. (2017) Synthesis, characterization and biological activity of Rhein-cyclodextrin conjugate. JOURNAL OF MOLECULAR STRUCTURE, 1128 (239). [PMID:] [10.1016/j.molstruc.2016.08.047] |
24. Xingqiang Wu, Shuxuan Liang, Xusheng Ge, Yunkai Lv, Hanwen Sun. (2015) Synthesis and evaluation of dummy molecularly imprinted microspheres for the specific solid-phase extraction of six anthraquinones from slimming tea. JOURNAL OF SEPARATION SCIENCE, 38 (8): (1263-1270). [PMID:25677958] [10.1002/jssc.201401341] |
25. Gong Hao, He Zihao, Peng Anlin, Zhang Xin, Cheng Biao, Sun Yue, Zheng Ling, Huang Kun. (2014) Effects of several quinones on insulin aggregation. Scientific Reports, 4 (1): (1-8). [PMID:25008537] [10.1038/srep05648] |
26. Dan Li, Shaopu Liu, Yizhong Shen, Jidong Yang, Youqiu He. (2014) Molecular spectroscopic studies on the interactions of rhein and emodin with thioglycolic acid-capped core/shell CdTe/CdS quantum dots and their analytical applications. LUMINESCENCE, 30 (1): (60-66). [PMID:24850622] [10.1002/bio.2690] |
1. Taorong Shen, Xing Huang, Yanfei Zhang, Yanli Tong, Yakun Shi, Jianhe Guo, Xiaoyong Zou, Yuzhi Xu, Zong Dai. (2023) Dephosphorylation Switch DNAzyme-RCA Circuit: A Robust Strategy for the Homogeneous and Reliable Detection of FTO Demethylase. ANALYTICAL CHEMISTRY, [PMID:38118402] [10.1021/acs.analchem.3c04762] |
2. Bi Wang, Jingjing Yang, Xingzeng Zhao, Xu Feng, Shu Xu, Pirui Li, Linwei Li, Yu Chen. (2023) Antifungal activity of the botanical compound rhein against Phytophthora capsici and the underlying mechanisms. PEST MANAGEMENT SCIENCE, (6): [PMID:37897133] [10.1002/ps.7852] |
3. Yan Zhou, Tian-Xiu Qiu, Huan Wang, Ling Hu, Lei Liu, Jiong Chen. (2023) Application of rhein as an immunostimulant controls spring viremia of carp virus infection. FISH & SHELLFISH IMMUNOLOGY, 142 (109128). [PMID:37777100] [10.1016/j.fsi.2023.109128] |
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