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Rho Kinase Inhibitor V , CAS No.1072906-02-5
a cell-permeable and potent, ATP-binding pocket-targeting inhibitor of ROCK-II
Basic Description Synonyms BDBM25472 | J-001755 | HMS3229N11 | N-[4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxine-2-carboxamide | SCHEMBL1987209 | 1072906-02-5 | N-[4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxine-3-carboxamide | Rho Kinase Inhibitor V | DTXSID906486 Storage Temp Store at 2-8°C Shipped In Wet ice Product Description Rho Kinase Inhibitor V is a cell-permeable pyrazolyl carboxamide compound that acts as a potent, ATP-binding pocket-targeting inhibitor of Rock-2 (ROCK-II) and effectively inhibits the myosin light chain 2 phosphorylation on Thr18/Ser19 in A7r5 cells. Rho Kinase Inhibitor V affects the activities of PKA, MRCK, Akt1 and CYP-450 enzymes only at much higher concentrations.
Associated Targets(Human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name N-[4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxine-3-carboxamide INCHI InChI=1S/C18H15N3O3/c22-18(17-11-23-15-3-1-2-4-16(15)24-17)21-14-7-5-12(6-8-14)13-9-19-20-10-13/h1-10,17H,11H2,(H,19,20)(H,21,22) InChi Key MCQBNMPALTYSES-UHFFFAOYSA-N Canonical SMILES C1C(OC2=CC=CC=C2O1)C(=O)NC3=CC=C(C=C3)C4=CNN=C4 Isomeric SMILES C1C(OC2=CC=CC=C2O1)C(=O)NC3=CC=C(C=C3)C4=CNN=C4 PubChem CID 25093233 Molecular Weight 321.3
Chemical and Physical Properties Solubility Soluble in DMSO, and ethanol.
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