Rhodamine 123 - 98%, high purity , CAS No.62669-70-9

  • ≥98%
Item Number
R299309
Grouped product items
SKUSizeAvailabilityPrice Qty
R299309-5mg
5mg
In stock
$64.90
R299309-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$116.90
R299309-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$186.90
R299309-500mg
500mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$499.90
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Fluorescent Dye

Basic Description

SynonymsSCHEMBL3808879 | RH-123; R-22420 | RH-123 | rhodamine 110 methyl ester | CS-W012067 | Rhodamine 123, BioReagent, for fluorescence, >=85% (HPLC) | s3577 | F9995-1239 | CHEBI:8828 | RH 123 | 2-(6-Amino-3-imino-3H-xanthen-9-yl)benzoic acid methyl ester monoh
Specifications & Purity≥98%
Biochemical and Physiological MechanismsFluorescent dye most commonly used in flow cytometry as functional reporter for Pgp. Functional assays for MDR proteins are better prognostic indicators in cancer therapy than levels of MDR protein expression. Rh 123 can be used in multiparameter analyses
Storage TempStore at 2-8°C
Shipped InWet ice
Product Description

Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms

Associated Targets(Human)

A2780 (11979 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ABCG2 Tchem ATP-binding cassette sub-family G member 2 (4927 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ABCB11 Tchem Bile salt export pump (2311 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Abcb1b P-glycoprotein 1 (174 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Abcb1a P-glycoprotein 3 (492 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Acinetobacter baumannii (41033 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Saccharomyces cerevisiae (19171 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FM3A (1296 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Abcb1 Multidrug resistance protein 1 (79 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ABC1 ATP binding cassette transporter Abc1p (50 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name methyl 2-(3-amino-6-iminoxanthen-9-yl)benzoate;hydrochloride
INCHI InChI=1S/C21H16N2O3.ClH/c1-25-21(24)15-5-3-2-4-14(15)20-16-8-6-12(22)10-18(16)26-19-11-13(23)7-9-17(19)20;/h2-11,22H,23H2,1H3;1H
InChi Key MYFATKRONKHHQL-UHFFFAOYSA-N
Canonical SMILES COC(=O)C1=CC=CC=C1C2=C3C=CC(=N)C=C3OC4=C2C=CC(=C4)N.Cl
Isomeric SMILES COC(=O)C1=CC=CC=C1C2=C3C=CC(=N)C=C3OC4=C2C=CC(=C4)N.Cl
WGK Germany 3
PubChem CID 9929799
Molecular Weight 380.82
Beilstein 6030951

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

12 results found

Lot NumberCertificate TypeDateItem
F2411426Certificate of AnalysisMay 27, 2024 R299309
F2411427Certificate of AnalysisMay 27, 2024 R299309
F2411428Certificate of AnalysisMay 27, 2024 R299309
F2411429Certificate of AnalysisMay 27, 2024 R299309
F2411430Certificate of AnalysisMay 27, 2024 R299309
K2415064Certificate of AnalysisNov 23, 2023 R299309
L2318379Certificate of AnalysisNov 23, 2023 R299309
L2318380Certificate of AnalysisNov 23, 2023 R299309
L2318381Certificate of AnalysisNov 23, 2023 R299309
L2318393Certificate of AnalysisNov 23, 2023 R299309
L2405098Certificate of AnalysisNov 23, 2023 R299309
G2219230Certificate of AnalysisJul 22, 2022 R299309

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Chemical and Physical Properties

SolubilitySoluble in ethanol (20 mg/ml), DMSO, methanol, and water (partly miscible).
Melt Point(°C)235°C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H302:Harmful if swallowed

Precautionary Statements

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P330:Rinse mouth.

P301+P317:IF SWALLOWED: Get medical help.

WGK Germany 3

Related Documents

Citations of This Product

1. Junwei Yao, Heng Zhi, Qingshan Shi, Yu Zhang, Jin Feng, Jingxia Liu, Hui Huang, Xiaobao Xie.  (2023)  Tannic Acid Interfacial Modification of Prochloraz Ethyl Cellulose Nanoparticles for Enhancing the Antimicrobial Effect and Biosafety of Fungicides.  ACS Applied Materials & Interfaces,  15  (35): (41324–41336).  [PMID:37602737] [10.1021/acsami.3c07761]
2. He Yan, Li Junjie, Yi Liling, Li Xiaohuan, Luo Man, Pang Yayan, Wang Maoju, Li Zhaolun, Xu Mingliang, Dong Zhifang, Du Yehong.  (2023)  Octadecaneuropeptide Ameliorates Cognitive Impairments Through Inhibiting Oxidative Stress in Alzheimer’s Disease Models.  JOURNAL OF ALZHEIMERS DISEASE,  92  (4): (1413-1426).  [PMID:36911940] [10.3233/JAD-221115]
3. Ruiyu Zhu, Weilun Wang, Zisheng Luo, Haiyan Lin, Yong Li, Weiqiang Lu, Zimu Xu, Chenggang Cai, Shuheng Hu.  (2023)  Blue LED light treatment inhibits virulence and patulin biosynthesis in Penicillium expansum.  POSTHARVEST BIOLOGY AND TECHNOLOGY,  200  (112340).  [PMID:] [10.1016/j.postharvbio.2023.112340]
4. Yu Le, Wang Zhuang, Wang De-Gao.  (2023)  Factors affecting the toxicity and oxidative stress of layered double hydroxide-based nanomaterials in freshwater algae.  ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,  30  (22): (63109-63120).  [PMID:36959400] [10.1007/s11356-023-26522-3]
5. Xiaomei Liang, Yulu Yang, Chuanqing Huang, Zhibin Ye, Wujiang Lai, Jiamao Luo, Xiaoxuan Li, Xiao Yi, Jun-Bing Fan, Ying Wang, Yifeng Wang.  (2023)  cRGD-targeted heparin nanoparticles for effective dual drug treatment of cisplatin-resistant ovarian cancer.  JOURNAL OF CONTROLLED RELEASE,  356  (691).  [PMID:36933699] [10.1016/j.jconrel.2023.03.017]
6. Jiali Qian, Hongli Li, Yuanhang Wang, Yixuan Li, Jie Yu, Lei Zhou, Qiaosheng Pu.  (2023)  Zwitterionic surfactant as an additive for efficient electrophoretic separation of easily absorbed rhodamine dyes on plastic microchips.  JOURNAL OF CHROMATOGRAPHY A,  1688  (463716).  [PMID:36565653] [10.1016/j.chroma.2022.463716]
7. Ge Jian, Xu Wei-jia, Chen Hai-feng, Dong Zong-hua, Liu Wei, Nian Fu-zhao, Liu Jun.  (2022)  Induction mechanism of cigarette smoke components (CSCs) on dyslipidemia and hepatic steatosis in rats.  Lipids in Health and Disease,  21  (1): (1-20).  [PMID:36348421] [10.1186/s12944-022-01725-8]
8. Xinyang Zhang, Zhendong Gan, Yanrui Wang, Xiaobin Tang, Guibai Li, Heng Liang.  (2022)  Effect of chemical cleaning on nanofiltration process in treating surface water.  Journal of Water Process Engineering,  50  (103271).  [PMID:] [10.1016/j.jwpe.2022.103271]
9. Bin Zhao, Lixuan Xu, Peixin Shen, Liang Wang, Yiran Qian, Xiaojia He, Xiuru Chu, Pengda Zhang.  (2023)  Effect of fulvic acid on transparent exopolymer particle formation and membrane fouling.  SEPARATION AND PURIFICATION TECHNOLOGY,  305  (122369).  [PMID:] [10.1016/j.seppur.2022.122369]
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23. Shihui Liu, Youdong Hu, Rongrong Tao, Qingwei Huo, Lin Wang, Chunzhi Tang, Changjiang Pan, Tao Gong, Nenggui Xu, Tao Liu.  (2019)  Immobilization of Fibronectin-Loaded Polyelectrolyte Nanoparticles on Cardiovascular Material Surface to Improve the Biocompatibility.  Biomed Research International,  2019  (5478369).  [PMID:31781622] [10.1155/2019/5478369]
24. Jia Liu, Zhilan Ye, Mengxi Xiang, Bingcheng Chang, Jinyuan Cui, Tiantian Ji, Lei Zhao, Qilin Li, Yan Deng, Luming Xu, Guobin Wang, Lin Wang, Zheng Wang.  (2019)  Functional extracellular vesicles engineered with lipid-grafted hyaluronic acid effectively reverse cancer drug resistance.  BIOMATERIALS,  223  (119475).  [PMID:31520888] [10.1016/j.biomaterials.2019.119475]
25. Peng Cao, Yu Zhang, Zi Huang, Mitchell A. Sullivan, Zihao He, Jinglin Wang, Zehong Chen, Huiping Hu, Kaiping Wang.  (2019)  The Preventative Effects of Procyanidin on Binge Ethanol-Induced Lipid Accumulation and ROS Overproduction via the Promotion of Hepatic Autophagy.  MOLECULAR NUTRITION & FOOD RESEARCH,  63  (18): (1801255).  [PMID:31336037] [10.1002/mnfr.201801255]
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27. Yanlan Lin, Xu Tang, Liangzong Xu, Shaoyun Wang.  (2019)  Antibacterial properties and possible action mechanism of chelating peptides-zinc nanocomposite against Escherichia coli.  FOOD CONTROL,  106  (106675).  [PMID:] [10.1016/j.foodcont.2019.06.001]
28. Fan Zhang, Nan Ye, Se Wang, Yue Meng, Hao Fang, Zhuang Wang, De-Gao Wang.  (2019)  Dissolved Organic Matter Modulates Algal Oxidative Stress and Membrane System Responses to Binary Mixtures of Nano-Metal-Oxides (nCeO2, nMgO and nFe3O4) and Sulfadiazine.  Nanomaterials,  (5): (712).  [PMID:31067831] [10.3390/nano9050712]
29. Jianyu Wang, Maomao Ma, Jun Yang, Long Chen, Ping Yu, Jun Wang, Deming Gong, Shuguang Deng, Xuefang Wen, Zheling Zeng.  (2018)  In Vitro Antibacterial Activity and Mechanism of Monocaprylin against Escherichia coli and Staphylococcus aureus.  JOURNAL OF FOOD PROTECTION,  81  (1988).  [PMID:30461297] [10.4315/0362-028X.JFP-18-248]
30. Zheng Fang, Liangzong Xu, Yanlan Lin, Xixi Cai, Shaoyun Wang.  (2019)  The preservative potential of Octopus scraps peptides−Zinc chelate against Staphylococcus aureus: Its fabrication, antibacterial activity and action mode.  FOOD CONTROL,  98  (24).  [PMID:] [10.1016/j.foodcont.2018.11.015]
31. Yue Meng, Se Wang, Zhuang Wang, Nan Ye, Hao Fang.  (2018)  Algal toxicity of binary mixtures of zinc oxide nanoparticles and tetrabromobisphenol A: Roles of dissolved organic matters.  ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,  64  (78).  [PMID:30308412] [10.1016/j.etap.2018.09.010]
32. Luming Xu, Jia Liu, Jiangbo Xi, Qilin Li, Bingcheng Chang, Xianming Duan, Guobin Wang, Shuai Wang, Zheng Wang, Lin Wang.  (2018)  Synergized Multimodal Therapy for Safe and Effective Reversal of Cancer Multidrug Resistance Based on Low-Level Photothermal and Photodynamic Effects.  Small,  14  (31): (1800785).  [PMID:29931728] [10.1002/smll.201800785]
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34. Du Yehong, Fu Min, Wang Yu Tian, Dong Zhifang.  (2018)  Neuroprotective Effects of Ginsenoside Rf on Amyloid-β-Induced Neurotoxicity in vitro and in vivo.  JOURNAL OF ALZHEIMERS DISEASE,  64  (1): (309-322).  [PMID:29865080] [10.3233/JAD-180251]
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37. Hu Cuihua, Chen Xiaolong, Huang Yibing, Chen Yuxin.  (2018)  Synergistic effect of the pro-apoptosis peptide kla-TAT and the cationic anticancer peptide HPRP-A1.  APOPTOSIS,  23  (2): (132-142).  [PMID:29397453] [10.1007/s10495-018-1443-1]
38. Zhiyu He, Zhijia Liu, Houkuan Tian, Yizong Hu, Lixin Liu, Kam W. Leong, Hai-Quan Mao, Yongming Chen.  (2018)  Scalable production of core–shell nanoparticles by flash nanocomplexation to enhance mucosal transport for oral delivery of insulin.  Nanoscale,  10  (7): (3307-3319).  [PMID:29384554] [10.1039/C7NR08047F]
39. Ying-Ying Wang, Xun Xiang, Ren Yan, Yi Liu, Feng-Lei Jiang.  (2018)  Förster Resonance Energy Transfer from Quantum Dots to Rhodamine B As Mediated by a Cationic Surfactant: A Thermodynamic Perspective.  Journal of Physical Chemistry C,  122  (2): (1148–1157).  [PMID:] [10.1021/acs.jpcc.7b08236]
40. Bing Zhang, Hongyun Meng, Xue Wang, Honghong Chang, Wenlong Wei.  (2017)  Bio-dye sensitized detection of Hg2+ based GO-ZnO-CdS nanohybrids.  SENSORS AND ACTUATORS B-CHEMICAL,  253  (495).  [PMID:] [10.1016/j.snb.2017.06.026]
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42. Jinxiu Guo, Zhaoyan Wang, Ping Sun, Qianyong Tang, Hongli Li, Xiayan Wang, Guangsheng Guo, Qiaosheng Pu.  (2017)  Ionic polymer enhanced electrophoresis in plastic microchips for rapid and robust determination of rhodamine dyes.  SENSORS AND ACTUATORS B-CHEMICAL,  250  (250).  [PMID:] [10.1016/j.snb.2017.04.123]
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45. Huanan Wang, Ming Yao, Wenqing Xu.  (2016)  The antitumor effects of mitochondria-targeted 6-(nicotinamide) methyl coumarin.  Open Life Sciences,  11  (1): (542-551).  [PMID:] [10.1515/biol-2016-0070]
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47. Weihua Jiang, Lei Yang, Lipeng Qiu, Jingwen Xu, Xiuchun Yang, Ju Wang, Hui Zhou, Dongkai Wang.  (2015)  Multifunctional hybrid nanoparticles based on sodium carboxymethylcellulose-graft-histidine and TPGS for enhanced effect of docetaxel.  RSC Advances,  (66): (53835-53845).  [PMID:] [10.1039/C5RA05586E]

References

1. Junwei Yao, Heng Zhi, Qingshan Shi, Yu Zhang, Jin Feng, Jingxia Liu, Hui Huang, Xiaobao Xie.  (2023)  Tannic Acid Interfacial Modification of Prochloraz Ethyl Cellulose Nanoparticles for Enhancing the Antimicrobial Effect and Biosafety of Fungicides.  ACS Applied Materials & Interfaces,  15  (35): (41324–41336).  [PMID:37602737] [10.1021/acsami.3c07761]
2. He Yan, Li Junjie, Yi Liling, Li Xiaohuan, Luo Man, Pang Yayan, Wang Maoju, Li Zhaolun, Xu Mingliang, Dong Zhifang, Du Yehong.  (2023)  Octadecaneuropeptide Ameliorates Cognitive Impairments Through Inhibiting Oxidative Stress in Alzheimer’s Disease Models.  JOURNAL OF ALZHEIMERS DISEASE,  92  (4): (1413-1426).  [PMID:36911940] [10.3233/JAD-221115]
3. Ruiyu Zhu, Weilun Wang, Zisheng Luo, Haiyan Lin, Yong Li, Weiqiang Lu, Zimu Xu, Chenggang Cai, Shuheng Hu.  (2023)  Blue LED light treatment inhibits virulence and patulin biosynthesis in Penicillium expansum.  POSTHARVEST BIOLOGY AND TECHNOLOGY,  200  (112340).  [PMID:] [10.1016/j.postharvbio.2023.112340]
4. Yu Le, Wang Zhuang, Wang De-Gao.  (2023)  Factors affecting the toxicity and oxidative stress of layered double hydroxide-based nanomaterials in freshwater algae.  ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,  30  (22): (63109-63120).  [PMID:36959400] [10.1007/s11356-023-26522-3]
5. Xiaomei Liang, Yulu Yang, Chuanqing Huang, Zhibin Ye, Wujiang Lai, Jiamao Luo, Xiaoxuan Li, Xiao Yi, Jun-Bing Fan, Ying Wang, Yifeng Wang.  (2023)  cRGD-targeted heparin nanoparticles for effective dual drug treatment of cisplatin-resistant ovarian cancer.  JOURNAL OF CONTROLLED RELEASE,  356  (691).  [PMID:36933699] [10.1016/j.jconrel.2023.03.017]
6. Jiali Qian, Hongli Li, Yuanhang Wang, Yixuan Li, Jie Yu, Lei Zhou, Qiaosheng Pu.  (2023)  Zwitterionic surfactant as an additive for efficient electrophoretic separation of easily absorbed rhodamine dyes on plastic microchips.  JOURNAL OF CHROMATOGRAPHY A,  1688  (463716).  [PMID:36565653] [10.1016/j.chroma.2022.463716]
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Solution Calculators