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Rhynchophylline - analytical standard，≥98%, high purity , CAS No.76-66-4
Ca 2+ channel blocker. Non-competitive NMDA antagonist.
Basic Description Synonyms Rhynchophylline | Mitrinermine | Rhyncophylline | Rhynchophyllin | 76-66-4 | Mitrinermin | Rhynocophylline | UNII-46BQ79VJ8D | 46BQ79VJ8D | NSC 21731 | CHEMBL519266 | CHEBI:70069 | DTXSID70878612 | NSC-21731 | Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid,6'-ethyl-1,2,2',3',6 Specifications & Purity analytical standard, ≥98% Biochemical and Physiological Mechanisms Ca 2+ channel blocker. Non-competitive NMDA antagonist (IC 50 = 43.2 μM). Inhibits glutamate-induced neuronal death. Inhibits dopamine-induced apoptosis. Reduces endothelin-induced cerebral arteriole contraction. Storage Temp Store at 2-8°C Shipped In Wet ice Grade analytical standard Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name methyl (E)-2-[(3R,6'R,7'S,8'aS)-6'-ethyl-2-oxospiro[1H-indole-3,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7'-yl]-3-methoxyprop-2-enoate INCHI InChI=1S/C22H28N2O4/c1-4-14-12-24-10-9-22(17-7-5-6-8-18(17)23-21(22)26)19(24)11-15(14)16(13-27-2)20(25)28-3/h5-8,13-15,19H,4,9-12H2,1-3H3,(H,23,26)/b16-13+/t14-,15-,19-,22+/m0/s1 InChi Key DAXYUDFNWXHGBE-KAXDATADSA-N Canonical SMILES CCC1CN2CCC3(C2CC1C(=COC)C(=O)OC)C4=CC=CC=C4NC3=O Isomeric SMILES CC[C@H]1CN2CC[C@]3([C@@H]2C[C@@H]1/C(=C\OC)/C(=O)OC)C4=CC=CC=C4NC3=O PubChem CID 5281408 Molecular Weight 384.47
Chemical and Physical Properties Safety and Hazards(GHS) Pictogram(s) GHS06 Signal Danger Hazard Statements H300: Fatal if swallowed
Precautionary Statements P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P301+P316: IF SWALLOWED: Get emergency medical help immediately.
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