Basic Description

Synonyms	DTXSID70878612 \| CCG-268460 \| Rhynchophylline \| RHYNCHOPHYLLINE (CONSTITUENT OF CAT'S CLAW) [DSC] \| Rhynocophylline \| C09236 \| SCHEMBL2047380 \| NSC-21731 \| R0105 \| CHEBI:70069 \| NSC 21731 \| Q7321711 \| CORYNOXAN-16-CARBOXYLIC ACID, 16,17-DIDEHYDRO-17-METHO
Specifications & Purity	analytical standard, ≥98%
Biochemical and Physiological Mechanisms	Ca 2+ channel blocker. Non-competitive NMDA antagonist (IC 50 = 43.2 μM). Inhibits glutamate-induced neuronal death. Inhibits dopamine-induced apoptosis. Reduces endothelin-induced cerebral arteriole contraction.
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	analytical standard
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(Human)

HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)

Discover Target: HTR1A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ACE Tclin Angiotensin-converting enzyme (1423 Activities)

Discover Target: ACE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KCNH2 Tclin HERG (29587 Activities)

Discover Target: KCNH2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KCNA2 Tclin Voltage-gated potassium channel subunit Kv1.2 (28 Activities)

Discover Target: KCNA2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HL-60 (67320 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SW480 (6023 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	methyl (E)-2-[(3R,6'R,7'S,8'aS)-6'-ethyl-2-oxospiro[1H-indole-3,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7'-yl]-3-methoxyprop-2-enoate
INCHI	InChI=1S/C22H28N2O4/c1-4-14-12-24-10-9-22(17-7-5-6-8-18(17)23-21(22)26)19(24)11-15(14)16(13-27-2)20(25)28-3/h5-8,13-15,19H,4,9-12H2,1-3H3,(H,23,26)/b16-13+/t14-,15-,19-,22+/m0/s1
InChi Key	DAXYUDFNWXHGBE-KAXDATADSA-N
Canonical SMILES	CCC1CN2CCC3(C2CC1C(=COC)C(=O)OC)C4=CC=CC=C4NC3=O
Isomeric SMILES	CC[C@H]1CN2CC[C@]3([C@@H]2C[C@@H]1/C(=C\OC)/C(=O)OC)C4=CC=CC=C4NC3=O
PubChem CID	5281408
Molecular Weight	384.47

Certificates

Certificate of Analysis(COA)

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1 results found

Lot Number	Certificate Type	Date	Item
K1510037	Certificate of Analysis	Apr 11, 2023	R102720

Chemical and Physical Properties

Melt Point(°C)	216°C

Safety and Hazards(GHS)

Pictogram(s)	GHS06
Signal	Danger
Hazard Statements	H300:Fatal if swallowed
Precautionary Statements	P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately.

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Meng Wang, Hui Li, Yaxin Zhao, Chuanfeng Lv, Guanghua Zhou. (2019) Rhynchophylline attenuates allergic bronchial asthma by inhibiting transforming growth factor‑β1‑mediated Smad and mitogen‑activated protein kinase signaling transductions in vivo and in vitro. Experimental and Therapeutic Medicine, 17 (1): (251-259). [PMID:30651790] [10.3892/etm.2018.6909]

References

1. Meng Wang, Hui Li, Yaxin Zhao, Chuanfeng Lv, Guanghua Zhou. (2019) Rhynchophylline attenuates allergic bronchial asthma by inhibiting transforming growth factor‑β1‑mediated Smad and mitogen‑activated protein kinase signaling transductions in vivo and in vitro. Experimental and Therapeutic Medicine, 17 (1): (251-259). [PMID:30651790] [10.3892/etm.2018.6909]

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Rhynchophylline - analytical standard，≥98%, high purity , CAS No.76-66-4