RI-1 - ≥98%, high purity , CAS No.415713-60-9

  • ≥98%
Item Number
R125517
Grouped product items
SKUSizeAvailabilityPrice Qty
R125517-10mg
10mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$127.90
R125517-50mg
50mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$246.90

RAD51 inhibitor

View related series
Cell Cycle/DNA Damage RAD51

Basic Description

SynonymsQ18392915 | HY-15317 | STL503566 | NCGC00371132-01 | RI1 | RI-1 | RI-1 (chemical) | RAD51 inhibitor 1 | UNII-S8WG8ZRQ99 | cid_1074953 | SW219349-1 | 3-chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione | N-(4-Hydroxy-3-methoxybenzyl)octa
Specifications & Purity≥98%
Biochemical and Physiological MechanismsRAD51 inhibitor. Inhibits homologous recombination and formation of subnuclear RAD51 foci in cells following DNA damage. Antitumor agent. Active in vitro .
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

RI-1 is a RAD51 inhibitor with IC50 ranging from 5 to 30 μM.

Associated Targets(Human)

BCL2A1 Tchem Bcl-2-related protein A1 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GAPDH Tchem Glyceraldehyde-3-phosphate dehydrogenase liver (1284 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK293 (82097 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BCL2A1 Tchem Bcl-2-related protein A1 (291 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RAD51 Tchem DNA repair protein RAD51 homolog 1 (504 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RAD1 Tchem Cell cycle checkpoint protein RAD1 (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 3-chloro-1-(3,4-dichlorophenyl)-4-morpholin-4-ylpyrrole-2,5-dione
INCHI InChI=1S/C14H11Cl3N2O3/c15-9-2-1-8(7-10(9)16)19-13(20)11(17)12(14(19)21)18-3-5-22-6-4-18/h1-2,7H,3-6H2
InChi Key MWSUIZKGNWELRF-UHFFFAOYSA-N
Canonical SMILES C1COCCN1C2=C(C(=O)N(C2=O)C3=CC(=C(C=C3)Cl)Cl)Cl
Isomeric SMILES C1COCCN1C2=C(C(=O)N(C2=O)C3=CC(=C(C=C3)Cl)Cl)Cl
PubChem CID 1074953
Molecular Weight 361.61

Certificates

Certificate of Analysis(COA)

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1 results found

Lot NumberChartCertificate TypeDateItem
F1509073Certificate of AnalysisJan 25, 2023 R125517

Chemical and Physical Properties

SolubilityDMSO 50 mg/mL;Water <1 mg/mL; EtOH <1 mg/mL

Related Documents

References

1. Barbieri EM et al..  (2017)  Precise Editing at DNA Replication Forks Enables Multiplex Genome Engineering in Eukaryotes..  Cell,  171  (6): (1453-1467.e13).  [PMID:29153834]

Solution Calculators