Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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R101754-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $64.90 | |
R101754-1g | 1g | In stock | $352.90 | |
R101754-5g | 5g | In stock | $1,587.90 | |
R101754-10g | 10g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,857.90 | |
R101754-25g | 25g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $6,429.90 | |
R101754-100g | 100g | In stock | $23,147.90 | |
R101754-500g | 500g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $104,162.90 |
Antiviral nucleoside
Synonyms | KBioSS_002331 | RBV | Ribavirin Teva | 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,2,4-triazole-3-carboxamide | Ribavirin [USAN:USP:INN:BAN] | 1-(beta-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide | Varazid | 1-((2R,3R,4S,5R |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | A non interferon-inducing, broad spectrum antiviral nucleoside. Active metabolites interfere with viral replication. Shows antiviral activity against a number of viruses including Hepatitis C, influenza and polio. |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Ribavirin is a non-interferon-inducing, broad spectrum antiviral nucleoside. Ribavirin is reported to be active against RSV, HIV, HCV, and other infectious agents. The compound’s metabolite, ribavirin-5′-phosphate, inhibits inosine monophosphate (IMP) dehydrogenase. |
ALogP | -1.8 |
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IUPAC Name | 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide |
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INCHI | InChI=1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1 |
InChi Key | IWUCXVSUMQZMFG-AFCXAGJDSA-N |
Canonical SMILES | C1=NC(=NN1C2C(C(C(O2)CO)O)O)C(=O)N |
Isomeric SMILES | C1=NC(=NN1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)C(=O)N |
WGK Germany | 3 |
RTECS | XZ4250000 |
PubChem CID | 37542 |
Molecular Weight | 244.2 |
Reaxy-Rn | 892462 |
DrugBank Ligand | DB00811 |
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PubChem CID | 37542 |
CAS Registry No. | 36791-04-5 |
ChEMBL Ligand | CHEMBL1643 |
Wikipedia | Ribavirin |
ChEBI | CHEBI:63580 |
RCSB PDB Ligand | RBV |
Reactome Reaction | R-HSA-9678749, R-HSA-9680836 |
Reactome Drug | R-ALL-9680963 |
DrugCentral Ligand | 2373 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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D2422028 | Certificate of Analysis | Mar 26, 2024 | R101754 |
D2422029 | Certificate of Analysis | Mar 26, 2024 | R101754 |
D2020053 | Certificate of Analysis | Feb 26, 2024 | R101754 |
H1905083 | Certificate of Analysis | May 08, 2023 | R101754 |
F1509078 | Certificate of Analysis | Apr 11, 2023 | R101754 |
C2406028 | Certificate of Analysis | Jun 28, 2022 | R101754 |
I2212285 | Certificate of Analysis | Jun 28, 2022 | R101754 |
I2212286 | Certificate of Analysis | Jun 28, 2022 | R101754 |
I2212287 | Certificate of Analysis | Jun 28, 2022 | R101754 |
I2212288 | Certificate of Analysis | Jun 28, 2022 | R101754 |
I2212308 | Certificate of Analysis | Jun 28, 2022 | R101754 |
I2212309 | Certificate of Analysis | Jun 28, 2022 | R101754 |
I2405039 | Certificate of Analysis | Jun 28, 2022 | R101754 |
L2312043 | Certificate of Analysis | Jun 28, 2022 | R101754 |
Solubility | Soluble in water (20 mg/ml), DMSO (49 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), and alcohol (slightly). |
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Specific Rotation[α] | -36 ° (C=1, H2O) |
Melt Point(°C) | 176°C |
Pictogram(s) | GHS08, GHS07 |
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Signal | Danger |
Hazard Statements | H319:Causes serious eye irritation H335:May cause respiratory irritation H341:Suspected of causing genetic defects H373:Causes damage to organs through prolonged or repeated exposure H412:Harmful to aquatic life with long lasting effects H317:May cause an allergic skin reaction H360:May damage fertility or the unborn child H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P260:Do not breathe dust/fume/gas/mist/vapors/spray. P281:Use personal protective equipment as required. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | XZ4250000 |
Reaxy-Rn | 892462 |
Merck Index | 8198 |
1. Weifeng Zhang, Hualong Deng, Yanfen Liu, Shaohong Chen, You Liu, Yuntao Zhao. (2023) Ribavirin inhibits peste des petits ruminants virus proliferation in vitro. VETERINARNI MEDICINA, 68 (12): ( 464–476). [PMID:38303996] |
2. Xiang Liu, Bing-Ke Li, Qin-Xue Liu, Peng-Fei Li, Fei Ling, Gao-Xue Wang. (2024) In vivo and in vitro antiviral effect and mechanisms of rhein against nervous necrosis virus. AQUACULTURE, 579 (740207). [PMID:19864460] |
3. Fuying Li, Shiying Chen, Haoxin Hu, Chengfeng Liang, Shiyu Sun, Can Jin, Fenghua Chen. (2023) Crystallization Selectivity of Ribavirin Solution and Amorphous Phase. MOLECULES, 28 (17): (6320). [PMID:37687147] |
4. Hongmei Dong, Lifeng Ding, Boyuan Ran, Yongbo Song, Ruihong Wang, Lu Zhao, Yulan Niu. (2023) A study on the anti-corrosion mechanism of the eco-friendly inhibitor Ribavirin on Q235 steel in an acidic chloride environment. International Journal of Electrochemical Science, 18 (100250). [PMID:] |
5. Kezhuo Zhang, Huadong Cai, Min Lu, Daixian Wei, Jiaqi Yin, Nengshui Ding, Weihua Lai, Juan Peng. (2022) Quantum dot nanobead immunochromatographic assay based on bispecific monoclonal antibody for the simultaneous detection of aflatoxin B1 and amantadine. FOOD AND AGRICULTURAL IMMUNOLOGY, 33 (1): (403-418). [PMID:] |
6. Yunlong Yan, Maoxi Huang, Li Wang, Wei Xue, Xin Xie, Xiangyang Li. (2022) Insights into a rapid screening method for anti-cucumber mosaic virus compounds. JOURNAL OF VIROLOGICAL METHODS, 301 (114402). [PMID:34871628] |
1. Keppeke GD et al.. (2018) IMP/GTP balance modulates cytoophidium assembly and IMPDH activity.. Cell Div, 13 (5). [PMID:29946345] |
2. Weifeng Zhang, Hualong Deng, Yanfen Liu, Shaohong Chen, You Liu, Yuntao Zhao. (2023) Ribavirin inhibits peste des petits ruminants virus proliferation in vitro. VETERINARNI MEDICINA, 68 (12): ( 464–476). [PMID:38303996] |
3. Xiang Liu, Bing-Ke Li, Qin-Xue Liu, Peng-Fei Li, Fei Ling, Gao-Xue Wang. (2024) In vivo and in vitro antiviral effect and mechanisms of rhein against nervous necrosis virus. AQUACULTURE, 579 (740207). [PMID:19864460] |
4. Fuying Li, Shiying Chen, Haoxin Hu, Chengfeng Liang, Shiyu Sun, Can Jin, Fenghua Chen. (2023) Crystallization Selectivity of Ribavirin Solution and Amorphous Phase. MOLECULES, 28 (17): (6320). [PMID:37687147] |
5. Hongmei Dong, Lifeng Ding, Boyuan Ran, Yongbo Song, Ruihong Wang, Lu Zhao, Yulan Niu. (2023) A study on the anti-corrosion mechanism of the eco-friendly inhibitor Ribavirin on Q235 steel in an acidic chloride environment. International Journal of Electrochemical Science, 18 (100250). [PMID:] |
6. Kezhuo Zhang, Huadong Cai, Min Lu, Daixian Wei, Jiaqi Yin, Nengshui Ding, Weihua Lai, Juan Peng. (2022) Quantum dot nanobead immunochromatographic assay based on bispecific monoclonal antibody for the simultaneous detection of aflatoxin B1 and amantadine. FOOD AND AGRICULTURAL IMMUNOLOGY, 33 (1): (403-418). [PMID:] |
7. Yunlong Yan, Maoxi Huang, Li Wang, Wei Xue, Xin Xie, Xiangyang Li. (2022) Insights into a rapid screening method for anti-cucumber mosaic virus compounds. JOURNAL OF VIROLOGICAL METHODS, 301 (114402). [PMID:34871628] |