RIP2 kinase inhibitor 2 - 99%, high purity , CAS No.1581270-11-2

Item Number

R651935

Grouped product items
SKU	Size	Availability	Price
R651935-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$168.90
R651935-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$420.90
R651935-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$600.90
R651935-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,800.90
R651935-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,520.90

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Basic Description

Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	RIP2 kinase inhibitor 2 is a receptor interacting protein-2 ( RIP2 ) kinase inhibitor extracted from patent WO/2014043437 A1, compound example 9.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	RIP2 kinase inhibitor 2 is a receptor interacting protein-2 ( RIP2 ) kinase inhibitor extracted from patent WO/2014043437 A1, compound example 9. In Vitro RIP2 kinase inhibitor 2 is a novel prodrug of a quinazolyl amine that inhibits RIP2 kinase. Receptor interacting protein-2 (RIP2) kinase is a TKL family serine/threonine protein kinase involved in innate immune signaling. Following activation, RIP2 kinase associates with NODI or NOD2 and appears to function principally as a molecular scaffold to bring together other kinases (TAK1, ΙΚΚα/β/γ) involved in NF-κΒ and mitogen-activated protein kinase activation. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:RIP2 Kinase

Associated Targets(Human)

RIPK2 Tchem Receptor-interacting serine/threonine-protein kinase 2 (2 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin HERG (29587 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RIPK2 Tchem Serine/threonine-protein kinase RIPK2 (1546 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	6-tert-butylsulfonyl-N-(4,5-dimethyl-1H-pyrazol-3-yl)-7-(2-methoxyethoxy)quinolin-4-amine
INCHI	InChI=1S/C21H28N4O4S/c1-13-14(2)24-25-20(13)23-16-7-8-22-17-12-18(29-10-9-28-6)19(11-15(16)17)30(26,27)21(3,4)5/h7-8,11-12H,9-10H2,1-6H3,(H2,22,23,24,25)
InChi Key	QODPGRHWJBWTJC-UHFFFAOYSA-N
Canonical SMILES	CC1=C(NN=C1NC2=C3C=C(C(=CC3=NC=C2)OCCOC)S(=O)(=O)C(C)(C)C)C
Isomeric SMILES	CC1=C(NN=C1NC2=C3C=C(C(=CC3=NC=C2)OCCOC)S(=O)(=O)C(C)(C)C)C
PubChem CID	73426595
Molecular Weight	432.54

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Basic Description