RIPK1-IN-7 - 98%, high purity , CAS No.2300982-44-7

Item Number

R647624

• Specifications & Purity: ≥98%
• Biochemical and Physiological Mechanisms: RIPK1-IN-7 is a potent and selective RIPK1 inhibitor with a K d of 4 nM and an enzymatic IC 50 of 11 nM. RIPK1-IN-7 exhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model.
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads

Product Description

RIPK1-IN-7 is a potent and selective RIPK1 inhibitor with a K d of 4 nM and an enzymatic IC 50 of 11 nM. RIPK1-IN-7 exhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model

In Vitro

RIPK1-IN-7 shows potent cell protection effect in the TSZ-induced HT29 cell necroptosis model with an EC 50 of 2nM. RIPK1-IN-7 displays considerable activity against several other kinases, such as Flt4, TrkA, TrkB, TrkC, Axl, HRI, Mer, and MAP4K5 with IC 50 s of 20, 26, 8, 7, 35, 26, 29, and 27 nM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:IC50: 11 nM (RIPK1), Kd: 4 nM (RIPK1)