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RIPK3 inhibitor 18 , CAS No.R613202, Inhibitor of discoidin domain receptor tyrosine kinase 2;Inhibitor of EPH receptor A5;Inhibitor of EPH receptor A8;Inhibitor of EPH receptor B2;Inhibitor of FGR proto-oncogene; Src family tyrosine kinase;Inhibitor of MET proto-oncogene; receptor tyrosine

Moligand™

PubChem CID: 138393291

Item Number

R613202

Grouped product items
SKU	Size	Availability	Price	Qty
R613202-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$305.90
R613202-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,065.90

View related series

discoidin domain receptor tyrosine kinase 2 Inhibitor EPH receptor A5 Inhibitor EPH receptor A8 Inhibitor EPH receptor B2 Inhibitor FGR proto-oncogene，Src family tyrosine kinase Inhibitor MET proto-oncogene，receptor tyrosine kinase Inhibitor mitogen-activated protein kinase kinase kinase kinase 3 Inhibitor Raf-1 proto-oncogene，serine/threonine kinase Inhibitor receptor interacting serine/threonine kinase 1 Inhibitor receptor interacting serine/threonine kinase 3 Inhibitor

Basic Description

Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of discoidin domain receptor tyrosine kinase 2;Inhibitor of EPH receptor A5;Inhibitor of EPH receptor A8;Inhibitor of EPH receptor B2;Inhibitor of FGR proto-oncogene; Src family tyrosine kinase;Inhibitor of MET proto-oncogene; receptor tyrosine

Associated Targets

EPHA8 Tchem Ephrin type-A receptor 8 0 Activities

Discover Target: EPHA8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EPHA5 Tchem Ephrin type-A receptor 5 0 Activities

Discover Target: EPHA5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DDR2 Tchem Discoidin domain-containing receptor 2 0 Activities

Discover Target: DDR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RAF1 Tclin RAF proto-oncogene serine/threonine-protein kinase 0 Activities

Discover Target: RAF1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EPHB2 Tchem Ephrin type-B receptor 2 0 Activities

Discover Target: EPHB2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FGR Tchem Tyrosine-protein kinase Fgr 0 Activities

Discover Target: FGR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MET Tclin Hepatocyte growth factor receptor 0 Activities

Discover Target: MET

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RIPK3 Tchem Receptor-interacting serine/threonine-protein kinase 3 0 Activities

Discover Target: RIPK3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RIPK2 Tchem Receptor-interacting serine/threonine-protein kinase 2 0 Activities

Discover Target: RIPK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RIPK1 Tchem Receptor-interacting serine/threonine-protein kinase 1 0 Activities

Discover Target: RIPK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAP4K3 Tchem Mitogen-activated protein kinase kinase kinase kinase 3 0 Activities

Discover Target: MAP4K3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-{4-[(2-cyclopropaneamidopyridin-4-yl)oxy]-2,3-dimethylphenyl}-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
INCHI	InChI=1S/C29H25FN4O4/c1-17-18(2)25(38-22-13-14-31-26(16-22)33-27(35)19-5-6-19)12-11-24(17)32-28(36)23-4-3-15-34(29(23)37)21-9-7-20(30)8-10-21/h3-4,7-16,19H,5-6H2,1-2H3,(H,32,36)(H,31,33,35)
InChi Key	PETCZXAONWLUFT-UHFFFAOYSA-N
Canonical SMILES	O=C(C1CC1)Nc1nccc(c1)Oc1ccc(c(c1C)C)NC(=O)c1cccn(c1=O)c1ccc(cc1)F
Isomeric SMILES	CC1=C(C=CC(=C1C)OC2=CC(=NC=C2)NC(=O)C3CC3)NC(=O)C4=CC=CN(C4=O)C5=CC=C(C=C5)F
PubChem CID	138393291

References

1. Yan B, Liu L, Huang S, Ren Y, Wang H, Yao Z, Li L, Chen S, Wang X, Zhang Z. (2017) Discovery of a new class of highly potent necroptosis inhibitors targeting the mixed lineage kinase domain-like protein.. Chem Commun (Camb.), 53 (26): (3637-3640). [PMID:28267172]
2. Bryan MC, Rajapaksa NS. (2018) Kinase Inhibitors for the Treatment of Immunological Disorders: Recent Advances.. J Med Chem, 61 (20): (9030-9058). [PMID:29870256]

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