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RIPK3 inhibitor 18 , CAS No.R613202, Inhibitor of discoidin domain receptor tyrosine kinase 2;Inhibitor of EPH receptor A5;Inhibitor of EPH receptor A8;Inhibitor of EPH receptor B2;Inhibitor of FGR proto-oncogene; Src family tyrosine kinase;Inhibitor of MET proto-oncogene; receptor tyrosine

Item Number
R613202
Grouped product items
SKUSizeAvailabilityPrice Qty
R613202-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$305.90
R613202-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,065.90
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View related series
discoidin domain receptor tyrosine kinase 2 Inhibitor EPH receptor A5 Inhibitor EPH receptor A8 Inhibitor EPH receptor B2 Inhibitor FGR proto-oncogene，Src family tyrosine kinase Inhibitor MET proto-oncogene，receptor tyrosine kinase Inhibitor mitogen-activated protein kinase kinase kinase kinase 3 Inhibitor Raf-1 proto-oncogene，serine/threonine kinase Inhibitor receptor interacting serine/threonine kinase 1 Inhibitor receptor interacting serine/threonine kinase 3 Inhibitor

Basic Description

Specifications & PurityMoligand™
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of discoidin domain receptor tyrosine kinase 2;Inhibitor of EPH receptor A5;Inhibitor of EPH receptor A8;Inhibitor of EPH receptor B2;Inhibitor of FGR proto-oncogene; Src family tyrosine kinase;Inhibitor of MET proto-oncogene; receptor tyrosine

Associated Targets(Human)

EPHA8 Tchem Ephrin type-A receptor 8 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
EPHA5 Tchem Ephrin type-A receptor 5 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
DDR2 Tchem Discoidin domain-containing receptor 2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
RAF1 Tclin RAF proto-oncogene serine/threonine-protein kinase (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
EPHB2 Tchem Ephrin type-B receptor 2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
FGR Tchem Tyrosine-protein kinase Fgr (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MET Tclin Hepatocyte growth factor receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
RIPK3 Tchem Receptor-interacting serine/threonine-protein kinase 3 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
RIPK1 Tchem Receptor-interacting serine/threonine-protein kinase 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MAP4K3 Tchem Mitogen-activated protein kinase kinase kinase kinase 3 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MET Tclin Hepatocyte growth factor receptor (10718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RIPK2 Tchem Serine/threonine-protein kinase RIPK2 (1546 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
U2OS (164939 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RIPK1 Tchem Receptor-interacting serine/threonine-protein kinase 1 (1548 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RIPK3 Tchem Receptor-interacting serine/threonine-protein kinase 3 (468 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name N-{4-[(2-cyclopropaneamidopyridin-4-yl)oxy]-2,3-dimethylphenyl}-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
INCHI InChI=1S/C29H25FN4O4/c1-17-18(2)25(38-22-13-14-31-26(16-22)33-27(35)19-5-6-19)12-11-24(17)32-28(36)23-4-3-15-34(29(23)37)21-9-7-20(30)8-10-21/h3-4,7-16,19H,5-6H2,1-2H3,(H,32,36)(H,31,33,35)
InChi Key PETCZXAONWLUFT-UHFFFAOYSA-N
Canonical SMILES O=C(C1CC1)Nc1nccc(c1)Oc1ccc(c(c1C)C)NC(=O)c1cccn(c1=O)c1ccc(cc1)F
Isomeric SMILES CC1=C(C=CC(=C1C)OC2=CC(=NC=C2)NC(=O)C3CC3)NC(=O)C4=CC=CN(C4=O)C5=CC=C(C=C5)F
PubChem CID 138393291

Certificates

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Related Documents

 SDS

 Specification Sheet

References

1. Yan B, Liu L, Huang S, Ren Y, Wang H, Yao Z, Li L, Chen S, Wang X, Zhang Z.  (2017)  Discovery of a new class of highly potent necroptosis inhibitors targeting the mixed lineage kinase domain-like protein..  Chem Commun (Camb.),  53  (26): (3637-3640).  [PMID:28267172] [10.1021/op500134e]
2. Bryan MC, Rajapaksa NS.  (2018)  Kinase Inhibitors for the Treatment of Immunological Disorders: Recent Advances..  J Med Chem,  61  (20): (9030-9058).  [PMID:29870256] [10.1021/op500134e]

Solution Calculators

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