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Risankizumab (anti-IL-23) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to IL23A, >95%, high purity, Human IgG1, INHIBITOR of Interleukin-23 inhibitor

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
Features and benefitsView More
  • Host species: Human
  • Species reactivity(Reacts with): Cynomolgus monkey,Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
Item Number
Ab169268
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab169268-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$139.90
Ab169268-1mg
1mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$657.90
Ab169268-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,407.90
Ab169268-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,457.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product NameRisankizumab (anti-IL-23) - Primary antibody, for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to IL23A, >95%, high purity, Human IgG1
SynonymsRecombinant Risankizumab Antibody | Risankizumab | Risankizumab rzaa | BI 655066 | Risankizumab (anti-IL-23) | Anti-IL-23a Reference Antibody (risankizumab) | IL 23 A antibody | IL 23 antibody | IL 23 subunit alpha antibody | IL 23A antibody | IL 23p19 an
Specifications & PurityCarrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host speciesHuman
SpecificityIL23A
ApplicationELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
ConjugationUnconjugated
GradeAzide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action TypeINHIBITOR
Mechanism of actionINHIBITOR of Interleukin-23 inhibitor
Product Description

Risankizumab targets the p19 subunit of IL-23. Risankizumab is indicated for the treatment of psoriasis and is safe and effective in maintaining remission in active Crohn's disease.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg 

Product Properties

Antibody TypePrimary antibody
ClonalityRecombinant
IsotypeHuman IgG1
Light Chain Typekappa
SDS-PAGE26.1 kDa (Light Chain) & 51.0 kDa (Heavy Chain), under reducing conditions; 166.7 kDa, under non-reducing conditions.
Purification MethodProtein A purified
Purity>95%
SourceCHO supernatant
FormLiquid
ConcentrationSee COA
Storage TempStore at -80°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS1612838-76-2

Images

Risankizumab (anti-IL-23) (Ab169268) - SEC
The purity of Risankizumab (anti-IL-23) (Ab169268) is more than 95% verified by HPLC.

Associated Targets(Human)

IL23A Tclin Interleukin-23 subunit alpha (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Certificates

C of A & Other Certificates

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot NumberCertificate TypeDateItem
ZJ23F0901031Certificate of AnalysisSep 14, 2023 Ab169268
ZJ23F0901029Certificate of AnalysisSep 14, 2023 Ab169268

Related Documents

References

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9. Gordon KB, Strober B, Lebwohl M, Augustin M, Blauvelt A, Poulin Y, Papp KA, Sofen H, Puig L, Foley P et al..  (2018)  Efficacy and safety of risankizumab in moderate-to-severe plaque psoriasis (UltIMMa-1 and UltIMMa-2): results from two double-blind, randomised, placebo-controlled and ustekinumab-controlled phase 3 trials..  Lancet,  392  (10148): (650-661).  [PMID:30097359] [10.1021/op500134e]
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14. Pirhonen, Jaana J, Matikainen, Sampsa S and Julkunen, Ilkka I..  (2002)  Regulation of virus-induced IL-12 and IL-23 expression in human macrophages..  Journal of immunology (Baltimore, Md. : 1950),    (15):   [PMID:12421946]
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24. Papp, K K and 12 more authors..  (2015)  Tildrakizumab (MK-3222), an anti-interleukin-23p19 monoclonal antibody, improves psoriasis in a phase IIb randomized placebo-controlled trial..  The British journal of dermatology,      [PMID:26042589]
25. Bloch, Yehudi and 11 more authors..  (2018)  Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23 Receptor Enables Recruitment of the Shared Receptor IL-12Rβ1..  Immunity,    (16):   [PMID:29287995]
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28. Sun, Rui and Abraham, Clara..  (2020)  IL23 Promotes Antimicrobial Pathways in Human Macrophages, Which Are Reduced With the IBD-Protective IL23R R381Q Variant..  Cellular and molecular gastroenterology and hepatology,      [PMID:32474165]
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