Risperidone is an antipsychotic; serotonin-dopamine antagonist.Atypical antipsychotic agent. Potent 5-HT 2A antagonist (K i = 0.4 nM). Also displays high affinity at D 2 receptors (K i = 3.13 nM).
Storage Temp
Store at 2-8°C
Shipped In
Wet ice
Grade
Moligand™
Action Type
ANTAGONIST
Mechanism of action
Dopamine D2 receptor antagonist
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Risperidone is a benzisoxazole derivative. It functions as an antagonist for dopamine D2, histamine H1 and α1 and α2 adrenergic receptors. Risperidone is used to treat schizophrenia, bipolar disorder and autism
Risperidone has been used:
• to study its effects on bone formation and differentiation
• to investigate the relationship between risperidone (RIS) dosages and RIS plasma levels in autism spectrum disorder (ASD) pediatric patients
• to reverse induced schizophrenia-like behavior in mice
1.Blessing WW et al.. (2017) Clozapine, chlorpromazine and risperidone dose-dependently reduce emotional hyperthermia, a biological marker of salience.. Psychopharmacology (Berl), 234 (21):(3259-3269). [PMID:28812124]
2.Fijal K et al.. (2014) Co-administration of 5-HT6 receptor antagonists with clozapine, risperidone, and a 5-HT2A receptor antagonist: effects on prepulse inhibition in rats.. Psychopharmacology (Berl), 231 (269-81). [PMID:23954911]
3.Malekizadeh Y et al.. (2020) Whole transcriptome in silico screening implicates cardiovascular and infectious disease in the mechanism of action underlying atypical antipsychotic side effects.. Alzheimers Dement (N Y), 6 (e12078). [PMID:32864416]
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I2208051