Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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R127644-500mg | 500mg | In stock | $57.90 | |
R127644-1g | 1g | In stock | $104.90 | |
R127644-5g | 5g | In stock | $469.90 | |
R127644-25g | 25g | In stock | $2,112.90 | |
R127644-100g | 100g | In stock | $7,604.90 |
Atypical antipsychotic. 5-HT 2A / D 2 antagonist.
Synonyms | CHEBI:8871 | Risperdal M-Tab | RISPERIDONE [HSDB] | RISPERIDONE [EP IMPURITY] | Risperidone M-tab | HMS2089C22 | PERSERIS KIT | R-64766 | R-64-766 | Risperidone impurity K | 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-te |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Risperidone is an antipsychotic; serotonin-dopamine antagonist.Atypical antipsychotic agent. Potent 5-HT 2A antagonist (K i = 0.4 nM). Also displays high affinity at D 2 receptors (K i = 3.13 nM). |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | ANTAGONIST |
Mechanism of action | Dopamine D2 receptor antagonist |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Risperidone is a benzisoxazole derivative. It functions as an antagonist for dopamine D2, histamine H1 and α1 and α2 adrenergic receptors. Risperidone is used to treat schizophrenia, bipolar disorder and autism Risperidone has been used: • to study its effects on bone formation and differentiation • to investigate the relationship between risperidone (RIS) dosages and RIS plasma levels in autism spectrum disorder (ASD) pediatric patients • to reverse induced schizophrenia-like behavior in mice |
ALogP | 2.7 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one |
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INCHI | InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3 |
InChi Key | RAPZEAPATHNIPO-UHFFFAOYSA-N |
Canonical SMILES | CC1=C(C(=O)N2CCCCC2=N1)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F |
Isomeric SMILES | CC1=C(C(=O)N2CCCCC2=N1)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F |
WGK Germany | 3 |
RTECS | UV1164800 |
PubChem CID | 5073 |
UN Number | 2811 |
Packing Group | III |
Molecular Weight | 410.48 |
Reaxy-Rn | 4891881 |
PubChem CID | 5073 |
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DrugBank Ligand | DB00734 |
CAS Registry No. | 106266-06-2 |
ChEBI | CHEBI:8871 |
Wikipedia | Risperidone |
BindingDB Ligand | 50001885 |
ChEMBL Ligand | CHEMBL85 |
PEP | risperidone |
RCSB PDB Ligand | 8NU |
DrugCentral Ligand | 2389 |
GPCRdb Ligand | risperidone |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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I2208051 | Certificate of Analysis | Jun 20, 2024 | R127644 |
I2208052 | Certificate of Analysis | Jun 20, 2024 | R127644 |
I2208053 | Certificate of Analysis | Jun 20, 2024 | R127644 |
I2208054 | Certificate of Analysis | Jun 20, 2024 | R127644 |
G2415162 | Certificate of Analysis | Apr 27, 2024 | R127644 |
G2404197 | Certificate of Analysis | Apr 27, 2024 | R127644 |
G2404198 | Certificate of Analysis | Apr 27, 2024 | R127644 |
J2120530 | Certificate of Analysis | Aug 18, 2023 | R127644 |
J2120574 | Certificate of Analysis | Aug 18, 2023 | R127644 |
J2120575 | Certificate of Analysis | Aug 18, 2023 | R127644 |
J2120576 | Certificate of Analysis | Aug 18, 2023 | R127644 |
K2026100 | Certificate of Analysis | Sep 20, 2022 | R127644 |
Solubility | Soluble in DMSO (10 mM), ethanol (10 mM), chloroform, and methanol. Insoluble in water. |
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Melt Point(°C) | 172 °C |
Pictogram(s) | GHS06, GHS08, GHS09 |
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Signal | Danger |
Hazard Statements | H301:Toxic if swallowed H331:Toxic if inhaled H351:Suspected of causing cancer H411:Toxic to aquatic life with long lasting effects |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P391:Collect spillage. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P318:if exposed or concerned, get medical advice. P316:Get emergency medical help immediately. |
WGK Germany | 3 |
RTECS | UV1164800 |
Reaxy-Rn | 4891881 |
Class | 6.1 |
Merck Index | 8233 |
1. Huanhuan Yang, Cong Liu, Chuanhong Zhu, Yan Zheng, Juan Li, Qianyun Zhu, Hao Wang, Xiangming Fang, Quan Liu, Man Liang, Zilong Liu. (2023) Determination of ten antipsychotics in blood, hair and nails: Validation of a LC–MS/MS method and forensic application of keratinized matrix analysis. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 234 (115557). [PMID:37406464] |
1. Blessing WW et al.. (2017) Clozapine, chlorpromazine and risperidone dose-dependently reduce emotional hyperthermia, a biological marker of salience.. Psychopharmacology (Berl), 234 (21): (3259-3269). [PMID:28812124] |
2. Fijal K et al.. (2014) Co-administration of 5-HT6 receptor antagonists with clozapine, risperidone, and a 5-HT2A receptor antagonist: effects on prepulse inhibition in rats.. Psychopharmacology (Berl), 231 (269-81). [PMID:23954911] |
3. Malekizadeh Y et al.. (2020) Whole transcriptome in silico screening implicates cardiovascular and infectious disease in the mechanism of action underlying atypical antipsychotic side effects.. Alzheimers Dement (N Y), 6 (e12078). [PMID:32864416] |
4. Huanhuan Yang, Cong Liu, Chuanhong Zhu, Yan Zheng, Juan Li, Qianyun Zhu, Hao Wang, Xiangming Fang, Quan Liu, Man Liang, Zilong Liu. (2023) Determination of ten antipsychotics in blood, hair and nails: Validation of a LC–MS/MS method and forensic application of keratinized matrix analysis. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 234 (115557). [PMID:37406464] |