Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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R126586-10mg | 10mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $122.90 | |
R126586-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $272.90 | |
R126586-250mg | 250mg | In stock | $570.90 | |
R126586-500mg | 500mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $867.90 | |
R126586-1g | 1g | In stock | $1,562.90 | |
R126586-5g | 5g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $7,030.90 | |
R126586-25g | 25g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $31,638.90 | |
R126586-100g | 100g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $113,898.90 |
HIV-1 and HIV-2 protease inhibitor
Synonyms | ritonavir | 155213-67-5 | Norvir | ABT-538 | Abbott 84538 | A-84538 | ABBOTT-84538 | Empetus | Ritomune | Ritovir | Viriton | RTV | ABT 538 | DRG-0244 | Ritonavirum | Viekirax | CHEBI:45409 | HSDB 7160 | TMC 114r | NSC-693184 | UNII-O3J8G9O825 | DTXSID1048627 | O3J8G9O825 | NSC693184 | CHEMBL163 | 1,3-th |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | HIV-1 and HIV-2 protease inhibitor (EC50values are 0.022-0.13 and 0.16μM, respectively). Blocks the metabolism of protease inhibitors by liver enzyme cytochrome P450-3A4 (CYP3A4). Orally bioavailable. When used in combination with lopinavir, improves outc |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Cytochrome P450 3A inhibitor |
Note | 卖完停产,不再备货 |
Product Description | Ritonavir is an antiretroviral (HIV) drug which inhibits a particular liver enzyme that normally metabolizes protease inhibitors, cytochrome P450-3A4 (CYP3A4). Application: Ritonavir has been used: as a human immunodeficiency virus (HIV) protease inhibitor to study its effects on placental endocrine function as an HIV protease inhibitor to study its effects on reduction of tetrazolium dye in human embryonic kidney cells as an organic anion transporting polypeptide (OATP) inhibitor to study its effect on hepatic uptake of bergapten and imperatorin |
ALogP | 6 |
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IUPAC Name | 1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate |
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INCHI | InChI=1S/C37H48N6O5S2/c1-24(2)33(42-36(46)43(5)20-29-22-49-35(40-29)25(3)4)34(45)39-28(16-26-12-8-6-9-13-26)18-32(44)31(17-27-14-10-7-11-15-27)41-37(47)48-21-30-19-38-23-50-30/h6-15,19,22-25,28,31-33,44H,16-18,20-21H2,1-5H3,(H,39,45)(H,41,47)(H,42,46)/t28-,31-,32-,33-/m0/s1 |
InChi Key | NCDNCNXCDXHOMX-XGKFQTDJSA-N |
Canonical SMILES | CC(C)C1=NC(=CS1)CN(C)C(=O)NC(C(C)C)C(=O)NC(CC2=CC=CC=C2)CC(C(CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)O |
Isomeric SMILES | CC(C)C1=NC(=CS1)CN(C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC2=CC=CC=C2)C[C@@H]([C@H](CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)O |
WGK Germany | 3 |
RTECS | XA5310000 |
PubChem CID | 392622 |
Molecular Weight | 720.94 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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H2231875 | Certificate of Analysis | Jun 20, 2024 | R126586 |
H2231876 | Certificate of Analysis | Jun 20, 2024 | R126586 |
H2231889 | Certificate of Analysis | Jun 20, 2024 | R126586 |
H2231890 | Certificate of Analysis | Jun 20, 2024 | R126586 |
H2231891 | Certificate of Analysis | Jun 20, 2024 | R126586 |
H2231892 | Certificate of Analysis | Jun 20, 2024 | R126586 |
H2231893 | Certificate of Analysis | Jun 20, 2024 | R126586 |
F1503111 | Certificate of Analysis | Jan 25, 2023 | R126586 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 14.42, Max Conc. mM: 20 with gentle warming; Solvent:ethanol, Max Conc. mg/mL: 7.21, Max Conc. mM: 10 |
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Pictogram(s) | GHS08, GHS07 |
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Signal | Warning |
Hazard Statements | H319:Causes serious eye irritation H351:Suspected of causing cancer H302:Harmful if swallowed H312:Harmful in contact with skin H332:Harmful if inhaled H302+H312+H332:Harmful if swallowed, in contact with skin or if inhaled H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. |
WGK Germany | 3 |
RTECS | XA5310000 |
1. Han Xie, Li Song, Sagie Katz, Jinyu Zhu, Yawen Liu, Jinping Tang, Linjun Cai, Peter Hildebrandt, Xiao Xia Han. (2022) Electron transfer between cytochrome c and microsomal monooxygenase generates reactive oxygen species that accelerates apoptosis. Redox Biology, 53 (102340). [PMID:35609401] |
2. Qing Shen, Huijuan Yang, Yunyan Li, Shiyan Li, Kang Chen, Honghai Wang, Haixing Wang, Jianfeng Ma. (2022) Rapid determination of antiviral drugs in yellow catfish (Pelteobagrus fulvidraco) using graphene/silica nanospheres (G/KCC-1) based pipette tip solid-phase extraction with ultra-performance liquid chromatography-tandem mass spectrometry. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1189 (123097). [PMID:35007897] |
1. Zeldin RK, Petruschke RA. (2004) Pharmacological and therapeutic properties of ritonavir-boosted protease inhibitor therapy in HIV-infected patients.. J Antimicrob Chemother, 53 (1): (4-9). [PMID:14657084] |
2. Han Xie, Li Song, Sagie Katz, Jinyu Zhu, Yawen Liu, Jinping Tang, Linjun Cai, Peter Hildebrandt, Xiao Xia Han. (2022) Electron transfer between cytochrome c and microsomal monooxygenase generates reactive oxygen species that accelerates apoptosis. Redox Biology, 53 (102340). [PMID:35609401] |
3. Qing Shen, Huijuan Yang, Yunyan Li, Shiyan Li, Kang Chen, Honghai Wang, Haixing Wang, Jianfeng Ma. (2022) Rapid determination of antiviral drugs in yellow catfish (Pelteobagrus fulvidraco) using graphene/silica nanospheres (G/KCC-1) based pipette tip solid-phase extraction with ultra-performance liquid chromatography-tandem mass spectrometry. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1189 (123097). [PMID:35007897] |