Rivastigmine Tartrate - ≥98%, high purity , Cholinesterases; ACHE & BCHE inhibitor, CAS No.129101-54-8, Cholinesterases; ACHE & BCHE inhibitor

  • ≥98%
Item Number
R129987
Grouped product items
SKUSizeAvailabilityPrice Qty
R129987-250mg
250mg
In stock
$46.90
R129987-1g
1g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$142.90
R129987-5g
5g
In stock
$495.90

Acetylcholinesterase and butyrylcholinesterase inhibitor

Basic Description

SynonymsQ27133236 | AKOS022179413 | AS-14385 | AKOS003617905 | Carbamic acid, ethylmethyl-, 3-(1-(dimethylamino)ethyl)phenyl ester, (S)-, (R-(R*,R*))-2,3-dihydroxybutanedioate (1:1) | HMS3884H05 | HMS3678F17 | SDZ-ENA 713 | ENA 713 | perfluoro-n-octanesulfonic ac
Specifications & Purity≥98%
Biochemical and Physiological MechanismsRivastigmine hydrogen tartrate is a parasympathomimetic or cholinergic agent. Rivastigmine hydrogen tartrate is also a dual ChEI (cholinesterase inhibitor); inhibiting BChE (butyrylcholinesterase) and AChE (acetylcholinesterase).Acetylcholinesterase and b
Storage TempStore at 2-8°C
Shipped InWet ice
Action TypeINHIBITOR
Mechanism of actionCholinesterases; ACHE & BCHE inhibitor
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Rivastigmine Tartrate is a cholinesterase inhibitor with IC50 of 5.5 μM, and used as a parasympathomimetic or cholinergic agent for the treatment of mild to moderate Alzheimer disease.
A parasympathomimetic or cholinergic agent.

Associated Targets(Human)

ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOB Tclin Monoamine oxidase B (8835 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BCHE Tclin Butyrylcholinesterase (7174 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (2R,3R)-2,3-dihydroxybutanedioic acid;[3-[(1S)-1-(dimethylamino)ethyl]phenyl] N-ethyl-N-methylcarbamate
INCHI InChI=1S/C14H22N2O2.C4H6O6/c1-6-16(5)14(17)18-13-9-7-8-12(10-13)11(2)15(3)4;5-1(3(7)8)2(6)4(9)10/h7-11H,6H2,1-5H3;1-2,5-6H,(H,7,8)(H,9,10)/t11-;1-,2-/m01/s1
InChi Key GWHQHAUAXRMMOT-MBANBULQSA-N
Canonical SMILES CCN(C)C(=O)OC1=CC=CC(=C1)C(C)N(C)C.C(C(C(=O)O)O)(C(=O)O)O
Isomeric SMILES CCN(C)C(=O)OC1=CC=CC(=C1)[C@H](C)N(C)C.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O
WGK Germany 3
RTECS FA9550000
PubChem CID 6918078
Molecular Weight 400.42

Certificates

Certificate of Analysis(COA)

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5 results found

Lot NumberCertificate TypeDateItem
F1501131Certificate of AnalysisJan 06, 2023 R129987
K2229795Certificate of AnalysisDec 09, 2022 R129987
F2216222Certificate of AnalysisJun 21, 2022 R129987
F2216220Certificate of AnalysisJun 20, 2022 R129987
F2216221Certificate of AnalysisJun 20, 2022 R129987

Chemical and Physical Properties

SolubilityDMSO 42 mg/mL Water 80 mg/mL Ethanol 80 mg/mL
Specific Rotation[α]5° (C=5,MeOH)
Melt Point(°C)126 °C

Safety and Hazards(GHS)

WGK Germany 3
RTECS FA9550000

Related Documents

Solution Calculators