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Rizatriptan Benzoate - ≥98%(HPLC), high purity , Serotonin 1d (5-HT1d) receptor agonist, CAS No.145202-66-0, Serotonin 1d (5-HT1d) receptor agonist

≥98%(HPLC)

CAS#: 145202-66-0
Formula: C₂₂H₂₅N₅O₂
Molecular Weight: 391.47
MDL number: MFCD00866224
PubChem CID: 77997

Item Number

R129638

Grouped product items
SKU	Size	Availability	Price
R129638-10mg	10mg	In stock	$48.90
R129638-50mg	50mg	In stock	$157.90
R129638-250mg	250mg	In stock	$711.90
R129638-1g	1g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,559.90
R129638-5g	5g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$11,518.90

Potent 5-HT1Band 5-HT1Dagonist

View related series

azole Five-Membered Heterocyclic Compounds

Basic Description

Synonyms	Rizatriptan benzoate\|145202-66-0\|Maxalt\|Maxalt-MLT\|MK 462\|Rizatriptan (benzoate)\|MK-462\|MK-0462\|MK 0462\|UNII-WR978S7QHH\|WR978S7QHH\|NSC-758919\|RIZAFILM\|2-(5-((1H-1,2,4-TRIAZOL-1-YL)METHYL)-1H-INDOL-3-YL)-N,N-DIMETHYLETHANAMINE BENZOATE\|L 705126\|L 705,126\|L
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	5-HT1B/1Dagonist. Antimigraine agent; attenuates effects of CGRP on light aversion in mice. Orally bioavailable.
Shipped In	Normal
Action Type	AGONIST
Mechanism of action	Serotonin 1d (5-HT1d) receptor agonist
Note	50mg、250mg卖完停产，不再备货
Product Description	A selective serotonin 5-HTID receptor agonist.

Associated Targets

ABCC2 Tchem Canalicular multispecific organic anion transporter 1 0 Activities

Discover Target: ABCC2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABCC3 Tbio Canalicular multispecific organic anion transporter 2 0 Activities

Discover Target: ABCC3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABCC4 Tchem Multidrug resistance-associated protein 4 0 Activities

Discover Target: ABCC4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABCB11 Tchem Bile salt export pump 0 Activities

Discover Target: ABCB11

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	benzoic acid;N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine
INCHI	InChI=1S/C15H19N5.C7H6O2/c1-19(2)6-5-13-8-17-15-4-3-12(7-14(13)15)9-20-11-16-10-18-20;8-7(9)6-4-2-1-3-5-6/h3-4,7-8,10-11,17H,5-6,9H2,1-2H3;1-5H,(H,8,9)
InChi Key	JPRXYLQNJJVCMZ-UHFFFAOYSA-N
Canonical SMILES	CN(C)CCC1=CNC2=C1C=C(C=C2)CN3C=NC=N3.C1=CC=C(C=C1)C(=O)O
Isomeric SMILES	CN(C)CCC1=CNC2=C1C=C(C=C2)CN3C=NC=N3.C1=CC=C(C=C1)C(=O)O
WGK Germany	3
PubChem CID	77997
Molecular Weight	391.47

Certificates

Certificate of Analysis(COA)

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Lot Number	Certificate Type	Date	Item
F1502086	Certificate of Analysis	Jan 25, 2023	R129638

Solubility

Solvent:water, Max Conc. mg/mL: 39.15, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 19.57, Max Conc. mM: 50

Melt Point(°C)

180 °C

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Danger
Hazard Statements	H319:Causes serious eye irritation H302:Harmful if swallowed H336:May cause drowsiness or dizziness H372:Causes damage to organs through prolonged or repeated exposure H360:May damage fertility or the unborn child H361:Suspected of damaging fertility or the unborn child H361d:Suspected of damaging the unborn child
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
Merck Index	8241

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