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RJR-2403 , CAS No.15585-43-0, Agonist of nicotinic acetylcholine receptor α4 subunit
Basic Description Synonyms Metanicotine | Rivanicline | RJR-2403 | 15585-43-0 | Trans-metanicotine | 538-79-4 | (E)-Metanicotine | Rivanicline [INN] | (E)-N-methyl-4-pyridin-3-ylbut-3-en-1-amine | (3E)-N-methyl-4-(3-pyridinyl)-3-buten-1-amine | (3E)-N-Methyl-4-(pyridin-3-yl)but-3-en-1-amine | CHEMBL1329 Specifications & Purity Moligand™ Biochemical and Physiological Mechanisms RJR-2403 (Rivanicline) is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki values are 26 and 36000 nM for α4β2 and α7 receptors respectively). Active in vivo.
Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type AGONIST Mechanism of action Agonist of nicotinic acetylcholine receptor α4 subunit
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name (E)-N-methyl-4-pyridin-3-ylbut-3-en-1-amine INCHI InChI=1S/C10H14N2/c1-11-7-3-2-5-10-6-4-8-12-9-10/h2,4-6,8-9,11H,3,7H2,1H3/b5-2+ InChi Key JUOSGGQXEBBCJB-GORDUTHDSA-N Canonical SMILES CNCCC=CC1=CN=CC=C1 Isomeric SMILES CNCC/C=C/C1=CN=CC=C1 PubChem CID 5310967 Molecular Weight 162.23
Chemical and Physical Properties
References 1. Bencherif M, Lovette ME, Fowler KW, Arrington S, Reeves L, Caldwell WS, Lippiello PM. (1996) RJR-2403: a nicotinic agonist with CNS selectivity I. In vitro characterization.. J Pharmacol Exp Ther, 279 (3): (1413-21). [PMID:8968366 ]
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