RK-24466 - 98%, high purity , CAS No.213743-31-8, Inhibitor of LCK proto-oncogene; Src family tyrosine kinase

Item Number

L339695

• Synonyms: 4-Amino-7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine | N16945 | HMS3261I22 | RK 24466 | CCG-204542 | NCGC00015280-05 | RK24466 | RK-24466 | 7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine, >=98% (HPLC) | B43 | NCGC0
• Specifications & Purity: Moligand™, ≥98%
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Inhibitor of LCK proto-oncogene; Src family tyrosine kinase

Product Description

Lck Inhibitor is a cell-permeable pyrrolopyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of Lck (IC|50|at 5 μM ATP = < 1 nM, 2 nM, 70 nM, 1.57 μM and 1.98 μM for lck|64-509|Y|39|4, Lckcd pY394, Src, Kdr and Tie-2, respectively; IC|50|at 1 mM ATP = 16 μM, 66 nM, 126 nM, 420 nM and 5.18 μM for Lck64-509 Y394, Blk, Fyn, Lyn and Csk, respectively). Only minimally affects the activities of other kinases (IC|50|= 3.2 μM, > 33 μM, > 50 μM and > 50 μM for EGFR, PKC, CDC2/B and ZAP-70, respectively). Also shown to potently block T-cell receptor-stimulated IL-2 production in vitro (IC50 < 1-40 nM in Jurkat T cells).