RK-682 - 95%, high purity , CAS No.154639-24-4

  • ≥95%
Item Number
R275023
Grouped product items
SKUSizeAvailabilityPrice Qty
R275023-1mg
1mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$532.90
R275023-200μg
200μg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$138.90

Potent, selective and competitive protein tyrosine phosphatase (PTP) inhibitor

Basic Description

Specifications & Purity≥95%
Biochemical and Physiological MechanismsPotent, selective and competitive protein tyrosine phosphatase (PTP) inhibitor (IC 50 values are 5.5, 54 and 2-11.6 μM at PTP1B, CD45 and VHR respectively). Inhibits cell cycle progression at G1/S transition.
Storage TempStore at -20°C,Desiccated
Shipped InIce chest + Ice pads
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Associated Targets(Human)

PTPN1 Tchem Tyrosine-protein phosphatase non-receptor type 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
VDR Tclin Vitamin D receptor (26531 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALB Tchem Serum albumin (2651 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACP1 Tchem Low molecular weight phosphotyrosine protein phosphatase (1161 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RECQL Tbio ATP-dependent DNA helicase Q1 (5575 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Cdc25b Dual specificity phosphatase Cdc25B (32 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ptpn1 Protein-tyrosine phosphatase 1B (270 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Lyz1 Lysozyme C (11 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GCN5 Histone acetyltransferase GCN5 (89 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapt Microtubule-associated protein tau (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 4-hexadecanoyl-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one
INCHI InChI=1S/C21H36O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-17(23)19-20(24)18(16-22)26-21(19)25/h18,22,24H,2-16H2,1H3
InChi Key KZTSLHQKWLYYAC-UHFFFAOYSA-N
Canonical SMILES CCCCCCCCCCCCCCCC(=O)C1=C(C(OC1=O)CO)O
Isomeric SMILES CCCCCCCCCCCCCCCC(=O)C1=C(C(OC1=O)CO)O
PubChem CID 54685915
Molecular Weight 368.5

Certificates

Certificate of Analysis(COA)

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Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot NumberCertificate TypeDateItem
G2219907Certificate of AnalysisMay 15, 2024 R275023
G2219908Certificate of AnalysisMay 15, 2024 R275023

Chemical and Physical Properties

SolubilitySoluble in DMSO to 50 mM and in ethanol to 25 mM

Related Documents

References

1. Kase Y et al..  (2022)  The GADD45G/p38 MAPK/CDC25B signaling pathway enhances neurite outgrowth by promoting microtubule polymerization..  iScience,  25  (4): (104089).  [PMID:35497000]

Solution Calculators