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RN 1747 - 98%(HPLC), high purity , CAS No.1024448-59-6, Activator of TRPV4

Moligand™

≥98%(HPLC)

CAS#: 1024448-59-6
Formula: C₁₇H₁₈ClN₃O₄S
Molecular Weight: 395.86
PubChem CID: 5068295

Item Number

R276121

Grouped product items
SKU	Size	Availability	Price
R276121-5mg	5mg	In stock	$75.90
R276121-10mg	10mg	In stock	$140.90
R276121-25mg	25mg	In stock	$256.90
R276121-50mg	50mg	In stock	$414.90
R276121-100mg	100mg	In stock	$662.90

Selective TRPV4 agonist

View related series

TRPV4 Activator

Basic Description

Synonyms	BDBM50545035 \| 1-benzyl-4-(4-chloro-2-nitrobenzenesulfonyl)piperazine \| CS-0017520 \| 1-benzyl-4-(4-chloro-2-nitrophenyl)sulfonylpiperazine \| HMS3678D03 \| HMS3414D03 \| AKOS040742557 \| HY-19976 \| DTXSID80408000 \| AC-36308 \| RN1747 \| RN-1747 \| RN-1747, >=98%
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Selective TRPV4 agonist (EC 50 = 0.77 μM, human; 4.0\xa0μM, mouse; 4.4\xa0μM rat).\xa0Has selectivity for\xa0TRP8 (EC 50 >30\xa0μM), TRPV3 (EC 50 = >30\xa0μM) and TRPV1 (EC 50 = >100\xa0μ). TRP8 antagonist at certain concentrations (EC 50 =\xa04\xa0μM).
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ACTIVATOR
Mechanism of action	Activator of TRPV4
Note	Refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Shipped at Room Temperature. Store at +4°C.

Associated Targets(Human)

TRPV4 Tchem Transient receptor potential cation channel subfamily V member 4 (3 Activities)

Discover Target: TRPV4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPV4 Tchem Transient receptor potential cation channel subfamily V member 4 (774 Activities)

Discover Target: TRPV4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	1-benzyl-4-(4-chloro-2-nitrophenyl)sulfonylpiperazine
INCHI	InChI=1S/C17H18ClN3O4S/c18-15-6-7-17(16(12-15)21(22)23)26(24,25)20-10-8-19(9-11-20)13-14-4-2-1-3-5-14/h1-7,12H,8-11,13H2
InChi Key	ZNLVYSJQUMALEO-UHFFFAOYSA-N
Canonical SMILES	C1CN(CCN1CC2=CC=CC=C2)S(=O)(=O)C3=C(C=C(C=C3)Cl)[N+](=O)[O-]
Isomeric SMILES	C1CN(CCN1CC2=CC=CC=C2)S(=O)(=O)C3=C(C=C(C=C3)Cl)[N+](=O)[O-]
WGK Germany	1
PubChem CID	5068295
Molecular Weight	395.86

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
F2230442	Certificate of Analysis	Apr 14, 2023	R276121
F2230391	Certificate of Analysis	Apr 14, 2023	R276121
F2230392	Certificate of Analysis	Apr 14, 2023	R276121
F2230393	Certificate of Analysis	Apr 14, 2023	R276121
F2230396	Certificate of Analysis	Apr 14, 2023	R276121

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H319:Causes serious eye irritation
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help.
WGK Germany	1
RIDADR	NONHforallmodesoftransport

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