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Ro 08-2750 - ≥95%(HPLC), high purity , CAS No.37854-59-4
Inhibits NGF binding to p75NTRand TrkA
Basic Description Synonyms SCHEMBL15683182 | HMS3677A14 | 7,10-dimethyl-2,4-dioxo-2,3,4,10-tetrahydrobenzo[g]pteridine-8-carbaldehyde | NCGC00159546-01 | 7,10-DIMETHYL-2,4-DIOXO-2H,3H,4H,10H-BENZO[G]PTERIDINE-8-CARBALDEHYDE | CHEBI:92012 | 2,3,4,10-Tetrahydro-7,10-dimethyl-2,4-diox Specifications & Purity ≥95%(HPLC) Biochemical and Physiological Mechanisms Non-peptide inhibitor of NGF that binds the NGF dimer (KD~ 1μM) possibly causing a conformational change. Selectively inhibits binding of NGF to p75NTRat submicromolar concentrations, and to both p75NTRand TrkA at concentrations > 5μM. Prevents NGF-induce Storage Temp Store at -20°C Shipped In Ice chest + Ice pads
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carbaldehyde INCHI InChI=1S/C13H10N4O3/c1-6-3-8-9(4-7(6)5-18)17(2)11-10(14-8)12(19)16-13(20)15-11/h3-5H,1-2H3,(H,16,19,20) InChi Key JDEMVNYMYPJJIM-UHFFFAOYSA-N Canonical SMILES CC1=CC2=C(C=C1C=O)N(C3=NC(=O)NC(=O)C3=N2)C Isomeric SMILES CC1=CC2=C(C=C1C=O)N(C3=NC(=O)NC(=O)C3=N2)C PubChem CID 17756791 Molecular Weight 270.24
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 2.7, Max Conc. mM: 10 with gentle warming
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