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Ro 106-9920 - ≥95%, high purity , CAS No.62645-28-7
NF-κB inhibitor. Anti-inflammatory agent.
Basic Description Synonyms 6-(benzenesulfinyl)tetrazolo[1,5-b]pyridazine | NSC793725 | NSC-793725 | SR-01000597505 | NCGC00025292-02 | CS-0029139 | BRD-A53134341-001-01-6 | HY-107665 | 6-(phenylsulfinyl)tetrazolo[1,5-b]pyridazine | Q27189566 | AKOS024456773 | HMS3268E20 | DTXSID803 Specifications & Purity ≥95% Biochemical and Physiological Mechanisms NF-κB inhibitor. Anti-inflammatory agent. Selectively inhibits LPS- and TNF-α-induced IκBα ubiquitination (IC 50 = 3 μM). Inhibits TNF-α, IL-1β and IL-6 production. Shows anti-inflammatory effects in vivo. Orally active. Storage Temp Store at -20°C,Desiccated Shipped In Ice chest + Ice pads Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. Product Description
Store at -20°C (desiccating conditions).
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References Vitamin D receptor agonist AGONIST ALA1977 Vitamin D receptor SINGLE PROTEIN Homo sapiens Vitamin D receptor agonist AGONIST ALA1977 Vitamin D receptor SINGLE PROTEIN Homo sapiens Vitamin D receptor agonist AGONIST ALA1977 Vitamin D receptor SINGLE PROTEIN Homo sapiens Vitamin D receptor agonist AGONIST ALA1977 Vitamin D receptor SINGLE PROTEIN Homo sapiens Vitamin D receptor agonist AGONIST ALA1977 Vitamin D receptor SINGLE PROTEIN Homo sapiens Vitamin D receptor agonist AGONIST ALA1977 Vitamin D receptor SINGLE PROTEIN Homo sapiens Vitamin D receptor agonist AGONIST ALA1977 Vitamin D receptor SINGLE PROTEIN Homo sapiens Vitamin D receptor agonist AGONIST ALA1977 Vitamin D receptor SINGLE PROTEIN Homo sapiens Vitamin D receptor agonist AGONIST ALA1977 Vitamin D receptor SINGLE PROTEIN Homo sapiens Vitamin D receptor agonist AGONIST ALA1977 Vitamin D receptor SINGLE PROTEIN Homo sapiens
Names and Identifiers IUPAC Name 6-(benzenesulfinyl)tetrazolo[1,5-b]pyridazine INCHI InChI=1S/C10H7N5OS/c16-17(8-4-2-1-3-5-8)10-7-6-9-11-13-14-15(9)12-10/h1-7H InChi Key JFSXSNSCPNFCDM-UHFFFAOYSA-N Canonical SMILES C1=CC=C(C=C1)S(=O)C2=NN3C(=NN=N3)C=C2 Isomeric SMILES C1=CC=C(C=C1)S(=O)C2=NN3C(=NN=N3)C=C2 PubChem CID 3906779 Molecular Weight 245.26
Certificates(CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solubility Soluble in ethanol to 10 mM and in DMSO to 100mM
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