Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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R275553-5mg | 5mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $48.90 | |
R275553-25mg | 25mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $157.90 | |
R275553-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $284.90 | |
R275553-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $511.90 |
Selective phosphodiesterase 4 (PDE4) inhibitor
Synonyms | BDBM50010981 | NCGC00015166-13 | (+-)-4-((3-butoxy-4-methoxyphenyl)methyl)-2-imidazolidinone | 4-(3-Butyl-4-methoxy-benzyl)-imidazolidin-2-one | 4-(3-Butoxy-4-methoxy-benzyl)-imidazolidin-2-one(Ro 20-1724) | Tox21_500204 | HY-100927 | HMS2231O19 | EU-0100 |
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Specifications & Purity | Moligand™, ≥99% |
Biochemical and Physiological Mechanisms | Selective cAMP-specific phosphodiesterase 4 (PDE4) inhibitor (IC 50 = 3 μM). Centrally active in vivo . |
Storage Temp | Store at -20°C,Desiccated |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of phosphodiesterase 4A;Inhibitor of phosphodiesterase 4B;Inhibitor of phosphodiesterase 4C;Inhibitor of phosphodiesterase 4D |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
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IUPAC Name | 4-[(3-butoxy-4-methoxyphenyl)methyl]imidazolidin-2-one |
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INCHI | InChI=1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18) |
InChi Key | PDMUULPVBYQBBK-UHFFFAOYSA-N |
Canonical SMILES | CCCCOC1=C(C=CC(=C1)CC2CNC(=O)N2)OC |
Isomeric SMILES | CCCCOC1=C(C=CC(=C1)CC2CNC(=O)N2)OC |
PubChem CID | 5087 |
Molecular Weight | 278.35 |
CAS Registry No. | 29925-17-5 |
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PubChem CID | 5087 |
Wikipedia | Ro20-1724 |
ChEMBL Ligand | CHEMBL18701 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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H2215019 | Certificate of Analysis | May 12, 2023 | R275553 |
H2215020 | Certificate of Analysis | May 12, 2023 | R275553 |
H2215135 | Certificate of Analysis | May 12, 2023 | R275553 |
H2215289 | Certificate of Analysis | May 12, 2023 | R275553 |
Solubility | Soluble in DMSO to 100 mM and in ethanol to 100 mM |
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Sensitivity | Moisture sensitive |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |