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Ro 25-6981 - ≥98%, high purity , CAS No.169274-78-6

≥98%

CAS#: 169274-78-6
Formula: C₂₂H₂₉NO₂
Molecular Weight: 339.47
PubChem CID: 6604887

Item Number

R274967

Grouped product items
SKU	Size	Availability	Price
R274967-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$71.90
R274967-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$147.90
R274967-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$631.90

Discover Ro 25-6981 by Aladdin Scientific in ≥98% for only $71.90. Available - in Ligands at Aladdin Scientific. NR2B antagonist Tags: .

Basic Description

Synonyms	Ro 25-6981\|169274-78-6\|Ro-25-6981\|4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol\|ro25-6981\|CHEMBL305195\|(AR,BS)-ALPHA-(4-HYDROXYPHENYL)-BETA-METHYL-4-(PHENYLMETHYL)-1-PIPERIDINEPROPANOL MALEATE\|4-((1R,2S)-3-(4-benzylpiperidin-1-yl)-
Specifications & Purity	≥98%
Storage Temp	Room temperature,Desiccated
Shipped In	Normal
Product Description	Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.

Names and Identifiers

IUPAC Name	4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol
INCHI	InChI=1S/C22H29NO2/c1-17(22(25)20-7-9-21(24)10-8-20)16-23-13-11-19(12-14-23)15-18-5-3-2-4-6-18/h2-10,17,19,22,24-25H,11-16H2,1H3/t17-,22+/m0/s1
InChi Key	WVZSEUPGUDIELE-HTAPYJJXSA-N
Canonical SMILES	CC(CN1CCC(CC1)CC2=CC=CC=C2)C(C3=CC=C(C=C3)O)O
Isomeric SMILES	C[C@@H](CN1CCC(CC1)CC2=CC=CC=C2)[C@H](C3=CC=C(C=C3)O)O
PubChem CID	6604887
Molecular Weight	339.47

Safety and Hazards(GHS)

Pictogram(s)	GHS09, GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H400:Very toxic to aquatic life
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

References

1. Ye ZY et al.. (2012) Casein kinase 2-mediated synaptic GluN2A up-regulation increases N-methyl-D-aspartate receptor activity and excitability of hypothalamic neurons in hypertension.. J Biol Chem, 287 (21): (17438-46). [PMID:22474321]
2. Zhao YL et al.. (2012) Chronic opioid potentiates presynaptic but impairs postsynaptic N-methyl-D-aspartic acid receptor activity in spinal cords: implications for opioid hyperalgesia and tolerance.. J Biol Chem, 287 (30): (25073-85). [PMID:22679016]
3. McNally JM et al.. (2011) Complex receptor mediation of acute ketamine application on in vitro gamma oscillations in mouse prefrontal cortex: modeling gamma band oscillation abnormalities in schizophrenia.. Neuroscience, 199 (51-63). [PMID:22027237]
4. Wills TA et al.. (2013) Developmental changes in the acute ethanol sensitivity of glutamatergic and GABAergic transmission in the BNST.. Alcohol, 47 (7): (531-7). [PMID:24103431]
5. Gunn BG et al.. (2013) Dysfunctional astrocytic and synaptic regulation of hypothalamic glutamatergic transmission in a mouse model of early-life adversity: relevance to neurosteroids and programming of the stress response.. J Neurosci, 33 (50): (19534-54). [PMID:24336719]
6. Wills TA et al.. (2012) GluN2B subunit deletion reveals key role in acute and chronic ethanol sensitivity of glutamate synapses in bed nucleus of the stria terminalis.. Proc Natl Acad Sci U S A, 109 (5): (E278-87). [PMID:22219357]
7. Le Roux N et al.. (2013) Input-specific learning rules at excitatory synapses onto hippocampal parvalbumin-expressing interneurons.. J Physiol, 591 (Pt 7): (1809-22). [PMID:23339172]
8. Henneberger C et al.. (2020) LTP Induction Boosts Glutamate Spillover by Driving Withdrawal of Perisynaptic Astroglia.. Neuron, 108 (5): (919-936.e11). [PMID:32976770]
9. Che A et al.. (2013) The Dyslexia-Associated Gene Dcdc2 Is Required for Spike-Timing Precision in Mouse Neocortex.. Biol Psychiatry, [PMID:24094509]

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Ro 25-6981 - ≥98%, high purity , CAS No.169274-78-6

Basic Description

Associated Targets

GRIN2B Tclin Glutamate receptor ionotropic, NMDA 2B 3 Activities

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Safety and Hazards(GHS)

Related Documents

References

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