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Ro 26-4550 trifluoroacetate - ≥98%, high purity , CAS No.193744-04-6, Antagonist of Interleukin-2 receptor
a small-molecule IL-2 inhibitor
Basic Description Synonyms Trifluoroacetic acid--methyl N-{[(3R)-1-carbamimidoylpiperidin-3-yl]acetyl}-4-(phenylethynyl)-L-phenylalaninate (1/1) | N-[[(3R)-1-(Aminoiminomethyl)-3-piperidinyl]acetyl]-4-(phenylethynyl)-L-phenylalaninemethylestertrifluoroacetate | AKOS024456786 | meth Specifications & Purity Moligand™, ≥98% Storage Temp Store at 2-8°C,Desiccated Shipped In Wet ice Grade Moligand™ Action Type ANTAGONIST Mechanism of action Antagonist of Interleukin-2 receptor Product Description Ro 26-4550 trifluoroacetate is a reversible, small-molecule inhibitor which prevents binding between interleukin-2 (IL-2) and its receptor (IL-2R α-subunit). It appears to compete with IL-2Rα for its binding site on IL-2 (IC|50|= 3 μM).
Associated Targets(Human) Names and Identifiers IUPAC Name methyl (2S)-2-[[2-[(3R)-1-carbamimidoylpiperidin-3-yl]acetyl]amino]-3-[4-(2-phenylethynyl)phenyl]propanoate;2,2,2-trifluoroacetic acid INCHI InChI=1S/C26H30N4O3.C2HF3O2/c1-33-25(32)23(29-24(31)17-22-8-5-15-30(18-22)26(27)28)16-21-13-11-20(12-14-21)10-9-19-6-3-2-4-7-19;3-2(4,5)1(6)7/h2-4,6-7,11-14,22-23H,5,8,15-18H2,1H3,(H3,27,28)(H,29,31);(H,6,7)/t22-,23+;/m1./s1 InChi Key BVMWPONRCOSTMK-RFPXDPOKSA-N Canonical SMILES COC(=O)C(CC1=CC=C(C=C1)C#CC2=CC=CC=C2)NC(=O)CC3CCCN(C3)C(=N)N.C(=O)(C(F)(F)F)O Isomeric SMILES COC(=O)[C@H](CC1=CC=C(C=C1)C#CC2=CC=CC=C2)NC(=O)C[C@H]3CCCN(C3)C(=N)N.C(=O)(C(F)(F)F)O PubChem CID 16760522 Molecular Weight 560.57
Chemical and Physical Properties Solubility Soluble to 50 mM in DMSO and to 5 mM in Ethanol
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