Ro 3306 - 98%, high purity , CAS No.872573-93-8, Inhibitor of cyclin dependent kinase 1;Inhibitor of cyclin dependent kinase 2;Inhibitor of cyclin dependent kinase 5
Ro 3306 - 98%, high purity , CAS No.872573-93-8, Inhibitor of cyclin dependent kinase 1;Inhibitor of cyclin dependent kinase 2;Inhibitor of cyclin dependent kinase 5
Selective cyclin-dependent kinase (Cdk1) inhibitor (K i values are 35 and 110 nM for cdk1/cyclin B1 and cdk1/cyclin A, respectively). Enhances downstream p53 signaling. Induces G2/M-phase cell cycle arrest and apoptosis.
Source
Synthetic
Storage Temp
Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of cyclin dependent kinase 1;Inhibitor of cyclin dependent kinase 2;Inhibitor of cyclin dependent kinase 5
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
1.Vassilev LT, Tovar C, Chen S, Knezevic D, Zhao X, Sun H, Heimbrook DC, Chen L. (2006) Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1.. Proc Natl Acad Sci USA, 103 (28):(10660-5). [PMID:16818887][10.1021/op500134e]
2.Jorda R, Hendrychová D, Voller J, Řezníčková E, Gucký T, Kryštof V. (2018) How Selective Are Pharmacological Inhibitors of Cell-Cycle-Regulating Cyclin-Dependent Kinases?. J Med Chem, 61 (20):(9105-9120). [PMID:30234987][10.1021/op500134e]
3.Matsubara S et al.. (2020) Fractionation of Ovarian Follicles and in vitro Oocyte Maturation and Ovulation Assay of Ciona intestinalis Type A.. Bio Protoc, 10 (7):(e3577). [PMID:33659547]
4.Huang CR et al.. (2021) Host CDK-1 and formin mediate microvillar effacement induced by enterohemorrhagic Escherichia coli.. Nat Commun, 12 (90). [PMID:33397943]
5.Mukherjee A et al.. (2020) Nuclear plasticity increases susceptibility to damage during confined migration.. PLoS Comput Biol, 16 (10):(e1008300). [PMID:33035221]
6.Matsubara S et al.. (2019) The regulation of oocyte maturation and ovulation in the closest sister group of vertebrates.. Elife, 8 [PMID:31573508]
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