Skip to the beginning of the images gallery

Ro 3306 - 98%, high purity , CAS No.872573-93-8, Inhibitor of cyclin dependent kinase 1;Inhibitor of cyclin dependent kinase 2;Inhibitor of cyclin dependent kinase 5

Moligand™
≥98%

CAS#: 872573-93-8
Formula: C₁₈H₁₃N₃OS₂
Molecular Weight: 351.44
MDL number: MFCD17392573
PubChem CID: 135400873

Item Number

R275210

Grouped product items
SKU	Size	Availability	Price
R275210-1mg	1mg	In stock	$21.90
R275210-5mg	5mg	In stock	$90.90
R275210-25mg	25mg	In stock	$184.90
R275210-50mg	50mg	In stock	$276.90

Selective cyclin-dependent kinase (Cdk1) inhibitor

View related series

cyclin dependent kinase 1 Inhibitor cyclin dependent kinase 2 Inhibitor cyclin dependent kinase 5 Inhibitor

Basic Description

Synonyms	(5Z)-5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino)-4(5H)-thiazolone
Specifications & Purity	98%
Source	Synthetic
Storage Temp	Store at -20°C,Desiccated
Shipped In	Dry ice
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of cyclin dependent kinase 1;Inhibitor of cyclin dependent kinase 2;Inhibitor of cyclin dependent kinase 5
Product Description	Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Associated Targets

CDK1 Tchem Cyclin-dependent kinase 1 2 Activities

Discover Target: CDK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CDK2 Tchem Cyclin-dependent kinase 2 2 Activities

Discover Target: CDK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CDK5 Tchem Cyclin-dependent-like kinase 5 1 Activities

Discover Target: CDK5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(5Z)-5-(quinolin-6-ylmethylidene)-2-(thiophen-2-ylmethylimino)-1,3-thiazolidin-4-one
INCHI	InChI=1S/C18H13N3OS2/c22-17-16(24-18(21-17)20-11-14-4-2-8-23-14)10-12-5-6-15-13(9-12)3-1-7-19-15/h1-10H,11H2,(H,20,21,22)/b16-10-
InChi Key	XOLMRFUGOINFDQ-YBEGLDIGSA-N
Canonical SMILES	C1=CC2=C(C=CC(=C2)C=C3C(=O)NC(=NCC4=CC=CS4)S3)N=C1
Isomeric SMILES	C1=CC2=C(C=CC(=C2)/C=C\3/C(=O)NC(=NCC4=CC=CS4)S3)N=C1
PubChem CID	135400873
Molecular Weight	351.44

PubChem CID

136240579

CAS Registry No.

872573-93-8

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

4 results found

Lot Number	Certificate Type	Date	Item
G2208332	Certificate of Analysis	Apr 17, 2023	R275210
G2208333	Certificate of Analysis	Apr 17, 2023	R275210
G2208286	Certificate of Analysis	Apr 17, 2023	R275210
G2208235	Certificate of Analysis	Apr 17, 2023	R275210

Solubility

insoluble in EtOH; insoluble in H2O; ≥4.39 mg/mL in DMSO

Sensitivity

Heat Sensitive

References

1. Vassilev LT, Tovar C, Chen S, Knezevic D, Zhao X, Sun H, Heimbrook DC, Chen L. (2006) Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1.. Proc Natl Acad Sci USA, 103 (28): (10660-5). [PMID:16818887]
2. Jorda R, Hendrychová D, Voller J, Řezníčková E, Gucký T, Kryštof V. (2018) How Selective Are Pharmacological Inhibitors of Cell-Cycle-Regulating Cyclin-Dependent Kinases?. J Med Chem, 61 (20): (9105-9120). [PMID:30234987]
3. Matsubara S et al.. (2020) Fractionation of Ovarian Follicles and in vitro Oocyte Maturation and Ovulation Assay of Ciona intestinalis Type A.. Bio Protoc, 10 (7): (e3577). [PMID:33659547]
4. Huang CR et al.. (2021) Host CDK-1 and formin mediate microvillar effacement induced by enterohemorrhagic Escherichia coli.. Nat Commun, 12 (90). [PMID:33397943]
5. Mukherjee A et al.. (2020) Nuclear plasticity increases susceptibility to damage during confined migration.. PLoS Comput Biol, 16 (10): (e1008300). [PMID:33035221]
6. Matsubara S et al.. (2019) The regulation of oocyte maturation and ovulation in the closest sister group of vertebrates.. Elife, 8 [PMID:31573508]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.