Ro 41-5253 - ≥99%, high purity , CAS No.144092-31-9, Antagonist of Retinoic acid receptor-α

Item Number
R275860
Grouped product items
SKUSizeAvailabilityPrice Qty
R275860-5mg
5mg
Available within 8-12 weeks(?)
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$197.90

Potent, selective retinoic acid receptor antagonist

Basic Description

SynonymsNCGC00485412-01 | Ro 415253 | Ro 41-5253 | SCHEMBL4183654 | CS-0064505 | MS-29010 | 4-((E)-2-(7-Heptoxy-4,4-dimethyl-1,1-dioxo-2,3-dihydrothiochromen-6-yl)prop-1-enyl)benzoic acid | Ro415253 | Ro-415253 | Ro-41-5253 | ro41-5253 | Q27088587 | R0-415253 | A
Specifications & PurityMoligand™, ≥99%
Biochemical and Physiological MechanismsPotent, selective retinoic acid receptor (RAR) antagonist (IC 50 values are 60 nM, 2400 nM and 3300 nM for RARα, RARβ and RARγ, respectively). Active in vitro .
Storage TempStore at -20°C,Desiccated
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeANTAGONIST
Mechanism of actionAntagonist of Retinoic acid receptor-α
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

Associated Targets(Human)

RARA Tclin Retinoic acid receptor alpha (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 4-[(E)-2-(7-heptoxy-4,4-dimethyl-1,1-dioxo-2,3-dihydrothiochromen-6-yl)prop-1-enyl]benzoic acid
INCHI InChI=1S/C28H36O5S/c1-5-6-7-8-9-15-33-25-19-26-24(28(3,4)14-16-34(26,31)32)18-23(25)20(2)17-21-10-12-22(13-11-21)27(29)30/h10-13,17-19H,5-9,14-16H2,1-4H3,(H,29,30)/b20-17+
InChi Key JEIWQRITHXYGIF-LVZFUZTISA-N
Canonical SMILES CCCCCCCOC1=CC2=C(C=C1C(=CC3=CC=C(C=C3)C(=O)O)C)C(CCS2(=O)=O)(C)C
Isomeric SMILES CCCCCCCOC1=CC2=C(C=C1/C(=C/C3=CC=C(C=C3)C(=O)O)/C)C(CCS2(=O)=O)(C)C
PubChem CID 5312120
Molecular Weight 484.7

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySoluble in DMSO to 100 mM and in ethanol to 25 mM (with warming)

Related Documents

Solution Calculators