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Ro 46-2005 - 98%, high purity , CAS No.150725-87-4

≥98%

CAS#: 150725-87-4
Formula: C₂₃H₂₇N₃O₆S
Molecular Weight: 473.54
PubChem CID: 122044

Item Number

R412180

Grouped product items
SKU	Size	Availability	Price
R412180-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$62.90
R412180-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$117.90
R412180-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$219.90
R412180-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$355.90

View related series

Endothelin Receptor GPCR/G Protein

Basic Description

Synonyms	4-(tert-butyl)-N-(6-(2-hydroxyethoxy)-5-(3-methoxyphenoxy)pyrimidin-4-yl)benzenesulfonamide \| HY-19529 \| 4-tert-Butyl-N-[6-(2-hydroxy-ethoxy)-5-(3-methoxy-phenoxy)-pyrimidin-4-yl]-benzenesulfonamide \| 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(3-methoxyphenox
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Ro 46-2005 is a novel synthetic non-peptide endothelin receptor antagonist. Ro 46-2005 inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA receptor) with IC50 of 220 nM.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Information Ro 46-2005 is a novel synthetic non-peptide endothelin receptor antagonist. Ro 46-2005 inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA receptor) with IC50 of 220 nM.

Associated Targets(Human)

EDNRB Tclin Endothelin receptor ET-B (1928 Activities)

Discover Target: EDNRB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EDNRA Tclin Endothelin receptor ET-A (5008 Activities)

Discover Target: EDNRA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Oryctolagus cuniculus (11301 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(3-methoxyphenoxy)pyrimidin-4-yl]benzenesulfonamide
INCHI	InChI=1S/C23H27N3O6S/c1-23(2,3)16-8-10-19(11-9-16)33(28,29)26-21-20(22(25-15-24-21)31-13-12-27)32-18-7-5-6-17(14-18)30-4/h5-11,14-15,27H,12-13H2,1-4H3,(H,24,25,26)
InChi Key	ZNXOKLWCOWOECF-UHFFFAOYSA-N
Canonical SMILES	CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NC=N2)OCCO)OC3=CC=CC(=C3)OC
Isomeric SMILES	CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NC=N2)OCCO)OC3=CC=CC(=C3)OC
PubChem CID	122044
Molecular Weight	473.54

Certificates

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7 results found

Lot Number	Certificate Type	Date	Item
H2401084	Certificate of Analysis	Apr 18, 2024	R412180
H2401085	Certificate of Analysis	Apr 18, 2024	R412180
H2401086	Certificate of Analysis	Apr 18, 2024	R412180
H2401087	Certificate of Analysis	Apr 18, 2024	R412180
H2401088	Certificate of Analysis	Apr 18, 2024	R412180
H2401089	Certificate of Analysis	Apr 18, 2024	R412180
H2401090	Certificate of Analysis	Apr 18, 2024	R412180

Safety and Hazards(GHS)

Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

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