RO 4938581 is a potent and selective GABA A α5 inverse agonist, with a K i of 4.6 nM for GABA A α5β3γ2a , and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a ( K i , 174, 185, 80 nM, respectively); RO 4938581 is used in the research of cognitive dysfu
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Product Description
RO 4938581 is a potent and selective GABA A α5 inverse agonist, with a K i of 4.6 nM for GABA A α5β3γ2a , and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a ( K i , 174, 185, 80 nM, respectively); RO 4938581 is used in the research of cognitive dysfunction.
In Vitro
RO 4938581 is a potent and selective GABA A α5 inverse agonist, with a K i of 4.6 nM for GABA A α5β3γ2a, and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a (K i , 174, 185, 80 nM, respectively). MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
RO 4938581 (0.3-1 mg/kg, p.o.) reverses a working memory impairment induced by scopolamine the delayed match to position (DMTP) task and a spatial learning impairment induced by diazepam (RO 4938581; 1-10 mg/kg, po) . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:Ki: 4.6 nM (GABA A α5β3γ2a), 174 nM (GABA A α1β3γ2a), 185 nM (GABA A α2β3γ2a), 80 nM (GABA A α3β3γ2a)
