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Ro 5-3335 - ≥98%(HPLC), high purity , CAS No.30195-30-3
Core binding factor inhibitor; attenuates hematopoiesis
Basic Description
| Synonyms | 7-Chloro-5-(2-pyrryl)-3H-1,4-benzodiazepin-2(H)-one | Ro 5-3335 | 2H-1, 7-chloro-1,3-dihydro-5-pyrrol-2-yl- | XWNMORIHKRROGW-UHFFFAOYSA-N | 7-Chloro-5-(1H-pyrrol-2-yl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one | UNII-DLH4T68L7I | DTXSID20184270 | HY-1084 |
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| Specifications & Purity | ≥98%(HPLC) |
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| Biochemical and Physiological Mechanisms | Core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50= 1.1μM). Represses RUNX1/CBFβ-dependent transactivation in reporter assays and inhibits transcriptional regulation by RUNX1 and CBFβ. Reduce |
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| Storage Temp | Store at -20°C |
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| Shipped In | Ice chest + Ice pads |
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Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Names and Identifiers
| IUPAC Name | 7-chloro-5-(1H-pyrrol-2-yl)-1,3-dihydro-1,4-benzodiazepin-2-one |
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| INCHI | InChI=1S/C13H10ClN3O/c14-8-3-4-10-9(6-8)13(11-2-1-5-15-11)16-7-12(18)17-10/h1-6,15H,7H2,(H,17,18) |
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| InChi Key | XWNMORIHKRROGW-UHFFFAOYSA-N |
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| Canonical SMILES | C1C(=O)NC2=C(C=C(C=C2)Cl)C(=N1)C3=CC=CN3 |
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| Isomeric SMILES | C1C(=O)NC2=C(C=C(C=C2)Cl)C(=N1)C3=CC=CN3 |
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| PubChem CID | 64983 |
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| Molecular Weight | 259.69 |
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Chemical and Physical Properties
| Solubility | Solvent:DMSO, Max Conc. mg/mL: 25.96, Max Conc. mM: 100 |
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| Sensitivity | Air Sensitive,Heat Sensitive |
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| Melt Point(°C) | 256 °C(dec.) |
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G2220156