The store will not work correctly when cookies are disabled.
JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
Ro 61-8048 - 10mM in DMSO, high purity , CAS No.199666-03-0
Potent, competitive kynurenine 3-monooxygenase (KMO) inhibitor
Basic Description Synonyms 199666-03-0 | Ro 61-8048 | 3,4-dimethoxy-N-(4-(3-nitrophenyl)thiazol-2-yl)benzenesulfonamide | Ro61-8048 | 3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide | Ro-61-8048 | 3,4-Dimethoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-benzenesulfonamide | CHEMB Specifications & Purity 10mM in DMSO Biochemical and Physiological Mechanisms Potent and competitive kynurenine 3-hydroxylase inhibitor (IC 50 = 37 nM). Shows antidystonic, anticonvulsant and neuroprotective effects in vivo. Orally active. Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Product Description Product Application：
Ro 61-8048 has been used as a kynurenine 3-monooxygenase (KMO) inhibitor to study its effects on nicotinamide adenine dinucleotide (NAD+) concentration in hepatocytes of mice.
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name 3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide INCHI InChI=1S/C17H15N3O6S2/c1-25-15-7-6-13(9-16(15)26-2)28(23,24)19-17-18-14(10-27-17)11-4-3-5-12(8-11)20(21)22/h3-10H,1-2H3,(H,18,19) InChi Key NDPBMCKQJOZAQX-UHFFFAOYSA-N Canonical SMILES COC1=C(C=C(C=C1)S(=O)(=O)NC2=NC(=CS2)C3=CC(=CC=C3)[N+](=O)[O-])OC Isomeric SMILES COC1=C(C=C(C=C1)S(=O)(=O)NC2=NC(=CS2)C3=CC(=CC=C3)[N+](=O)[O-])OC WGK Germany 3 PubChem CID 5282337 Molecular Weight 421.45
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H319: Causes serious eye irritation
H302: Harmful if swallowed
Precautionary Statements P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P301+P317: IF SWALLOWED: Get medical help.
P337+P317: If eye irritation persists: Get medical help.
WGK Germany 3
Solution Calculators Molarity Calculator Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator Determine the dilution needed to prepare a stock solution.
Reconstitution Calculator
