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RO-9187 - ≥99%, high purity , CAS No.876708-03-1

Item Number

R127469

Grouped product items
SKU	Size	Availability	Price
R127469-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$240.90
R127469-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$314.90
R127469-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$859.90

Basic Description

Synonyms	RO-9187\|876708-03-1\|RO 9187\|4-Amino-1-[(2r,3s,4s,5r)-5-azido-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one\|CHEMBL513181\|SCHEMBL13471886\|DTXSID30467889\|BKB70803\|EX-A6754\|AKOS040742565\|CS-0954\|NCGC00378981-01\|NCGC00378981-02\|CID 11514721\|HY-108
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	RO-9187 is a potent inhibitor of HCV virus replication in the replicon system (IC(50) = 171 +/- 12 nM; CC(50) >1 mM). Pharmacokinetic studies with RO-9187 in rats and dogs showed that plasma concentrations exceeding HCV replicon IC(50)
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IUPAC Name	4-amino-1-[(2R,3S,4S,5R)-5-azido-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
INCHI	InChI=1S/C9H12N6O5/c10-4-1-2-15(8(19)12-4)7-5(17)6(18)9(3-16,20-7)13-14-11/h1-2,5-7,16-18H,3H2,(H2,10,12,19)/t5-,6-,7+,9+/m0/s1
InChi Key	ODLGMSQBFONGNG-XZMZPDFPSA-N
Canonical SMILES	C1=CN(C(=O)N=C1N)C2C(C(C(O2)(CO)N=[N+]=[N-])O)O
Isomeric SMILES	C1=CN(C(=O)N=C1N)[C@H]2[C@H]([C@@H]([C@](O2)(CO)N=[N+]=[N-])O)O
PubChem CID	11514721
Molecular Weight	284.23

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Solubility	DMSO

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