RO495 - 98%, high purity , CAS No.1258296-60-4

  • ≥98%
Item Number
R412354
Grouped product items
SKUSizeAvailabilityPrice Qty
R412354-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$69.90
R412354-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$159.90
R412354-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$259.90
R412354-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$459.90
R412354-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$699.90
R412354-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,169.90

JAK Inhibitors

Basic Description

Specifications & Purity≥98%
Biochemical and Physiological MechanismsRO495 (CS-2667) is a potent inhibitor of Non-receptor tyrosine-protein kinase 2 (TYK2).
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Product Description

RO495 is an effective non receptor tyrosine protein kinase 2 inhibitor.

Information

RO495 RO495 (CS-2667) is a potent inhibitor of Non-receptor tyrosine-protein kinase 2 (TYK2) .

Targets

TYK2

Explanation

RO495, a potent inhibitor of TYK2, inhibits TYK2 with IC50 of 1.5nM as tested in cell-based pharmacological assays;


Product Properties

ALogP3.699
HBD Count3
Rotatable Bond4

Associated Targets(Human)

YES1 Tclin Tyrosine-protein kinase YES (2781 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name N-[2-[(2-amino-6-methylpyrimidin-4-yl)amino]pyridin-4-yl]-2,6-dichlorobenzamide
INCHI InChI=1S/C17H14Cl2N6O/c1-9-7-14(25-17(20)22-9)24-13-8-10(5-6-21-13)23-16(26)15-11(18)3-2-4-12(15)19/h2-8H,1H3,(H4,20,21,22,23,24,25,26)
InChi Key LNGDQKGREFSTHB-UHFFFAOYSA-N
Canonical SMILES CC1=CC(=NC(=N1)N)NC2=NC=CC(=C2)NC(=O)C3=C(C=CC=C3Cl)Cl
Isomeric SMILES CC1=CC(=NC(=N1)N)NC2=NC=CC(=C2)NC(=O)C3=C(C=CC=C3Cl)Cl
PubChem CID 57519505
Molecular Weight 389.24

Certificates

Certificate of Analysis(COA)

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11 results found

Lot NumberCertificate TypeDateItem
C2412433Certificate of AnalysisJan 24, 2024 R412354
C2412434Certificate of AnalysisJan 24, 2024 R412354
C2412435Certificate of AnalysisJan 24, 2024 R412354
C2412436Certificate of AnalysisJan 24, 2024 R412354
C2412437Certificate of AnalysisJan 24, 2024 R412354
C2412438Certificate of AnalysisJan 24, 2024 R412354
C2412451Certificate of AnalysisJan 24, 2024 R412354
C2412452Certificate of AnalysisJan 24, 2024 R412354
C2412453Certificate of AnalysisJan 24, 2024 R412354
C2412461Certificate of AnalysisJan 24, 2024 R412354
C2412462Certificate of AnalysisJan 24, 2024 R412354

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Chemical and Physical Properties

SolubilitySolubility (25°C) In vitro DMSO: 78 mg/mL (200.39 mM); Water: Insoluble; Ethanol: Insoluble;
DMSO(mg / mL) Max Solubility78
DMSO(mM) Max Solubility200.390504573014
Water(mg / mL) Max Solubility<1

Related Documents

Solution Calculators