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Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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R412354-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $69.90 | |
R412354-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $159.90 | |
R412354-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $259.90 | |
R412354-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $459.90 | |
R412354-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $699.90 | |
R412354-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,169.90 |
JAK Inhibitors
Specifications & Purity | ≥98% |
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Biochemical and Physiological Mechanisms | RO495 (CS-2667) is a potent inhibitor of Non-receptor tyrosine-protein kinase 2 (TYK2). |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Product Description | RO495 is an effective non receptor tyrosine protein kinase 2 inhibitor. Information RO495 RO495 (CS-2667) is a potent inhibitor of Non-receptor tyrosine-protein kinase 2 (TYK2) . Targets TYK2 Explanation RO495, a potent inhibitor of TYK2, inhibits TYK2 with IC50 of 1.5nM as tested in cell-based pharmacological assays; |
ALogP | 3.699 |
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HBD Count | 3 |
Rotatable Bond | 4 |
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | N-[2-[(2-amino-6-methylpyrimidin-4-yl)amino]pyridin-4-yl]-2,6-dichlorobenzamide |
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INCHI | InChI=1S/C17H14Cl2N6O/c1-9-7-14(25-17(20)22-9)24-13-8-10(5-6-21-13)23-16(26)15-11(18)3-2-4-12(15)19/h2-8H,1H3,(H4,20,21,22,23,24,25,26) |
InChi Key | LNGDQKGREFSTHB-UHFFFAOYSA-N |
Canonical SMILES | CC1=CC(=NC(=N1)N)NC2=NC=CC(=C2)NC(=O)C3=C(C=CC=C3Cl)Cl |
Isomeric SMILES | CC1=CC(=NC(=N1)N)NC2=NC=CC(=C2)NC(=O)C3=C(C=CC=C3Cl)Cl |
PubChem CID | 57519505 |
Molecular Weight | 389.24 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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C2412433 | Certificate of Analysis | Jan 24, 2024 | R412354 |
C2412434 | Certificate of Analysis | Jan 24, 2024 | R412354 |
C2412435 | Certificate of Analysis | Jan 24, 2024 | R412354 |
C2412436 | Certificate of Analysis | Jan 24, 2024 | R412354 |
C2412437 | Certificate of Analysis | Jan 24, 2024 | R412354 |
C2412438 | Certificate of Analysis | Jan 24, 2024 | R412354 |
C2412451 | Certificate of Analysis | Jan 24, 2024 | R412354 |
C2412452 | Certificate of Analysis | Jan 24, 2024 | R412354 |
C2412453 | Certificate of Analysis | Jan 24, 2024 | R412354 |
C2412461 | Certificate of Analysis | Jan 24, 2024 | R412354 |
C2412462 | Certificate of Analysis | Jan 24, 2024 | R412354 |
Solubility | Solubility (25°C) In vitro DMSO: 78 mg/mL (200.39 mM); Water: Insoluble; Ethanol: Insoluble; |
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DMSO(mg / mL) Max Solubility | 78 |
DMSO(mM) Max Solubility | 200.390504573014 |
Water(mg / mL) Max Solubility | <1 |
Starting at $199.90