Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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R276055-100μg | 100μg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $990.90 |
Potent inhibitor of NF-κB activation
Synonyms | FRG4N852F7 | B603847K064 | NSC326408 | Rocaglamide | 1H-Cyclopenta(b)benzofuran-2-carboxamide, 2,3,3a,8b-tetrahydro-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-, (1R,2R,3S,3aR,8bS)- | (1R,2R,3S,3aR,8bS)-1,8b-dihydroxy-6,8-dimet |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | Potent inhibitor of NF-κB activation. Suppresses cytokine production (IFN-γ, TNF-α, IL-2 and IL-4) and inhibits NF-AT in T cells. |
Storage Temp | Store at -20°C,Desiccated |
Shipped In | Ice chest + Ice pads |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Alpha-synuclein inhibitor | INHIBITOR | ALA6152 | Alpha-synuclein | SINGLE PROTEIN | Homo sapiens | ||
Alpha-synuclein binding agent | BINDING AGENT | ALA6152 | Alpha-synuclein | SINGLE PROTEIN | Homo sapiens | ||
Isocitrate dehydrogenase [NADP] cytoplasmic inhibitor | INHIBITOR | ALA2007625 | Isocitrate dehydrogenase [NADP] cytoplasmic | SINGLE PROTEIN | Homo sapiens | FDA: [1] | |
Isocitrate dehydrogenase [NADP] cytoplasmic inhibitor | INHIBITOR | ALA2007625 | Isocitrate dehydrogenase [NADP] cytoplasmic | SINGLE PROTEIN | Homo sapiens | PubMed: [1] | |
Isocitrate dehydrogenase [NADP] cytoplasmic inhibitor | INHIBITOR | ALA2007625 | Isocitrate dehydrogenase [NADP] cytoplasmic | SINGLE PROTEIN | Homo sapiens | ||
Isocitrate dehydrogenase [NADP] cytoplasmic inhibitor | INHIBITOR | ALA2007625 | Isocitrate dehydrogenase [NADP] cytoplasmic | SINGLE PROTEIN | Homo sapiens | ||
Isocitrate dehydrogenase [NADP] cytoplasmic inhibitor | INHIBITOR | ALA2007625 | Isocitrate dehydrogenase [NADP] cytoplasmic | SINGLE PROTEIN | Homo sapiens | ||
Isocitrate dehydrogenase [NADP] cytoplasmic inhibitor | INHIBITOR | ALA2007625 | Isocitrate dehydrogenase [NADP] cytoplasmic | SINGLE PROTEIN | Homo sapiens | ||
Isocitrate dehydrogenase [NADP] cytoplasmic inhibitor | INHIBITOR | ALA2007625 | Isocitrate dehydrogenase [NADP] cytoplasmic | SINGLE PROTEIN | Homo sapiens | ||
Isocitrate dehydrogenase [NADP] cytoplasmic inhibitor | INHIBITOR | ALA2007625 | Isocitrate dehydrogenase [NADP] cytoplasmic | SINGLE PROTEIN | Homo sapiens |
IUPAC Name | (1R,2R,3S,3aR,8bS)-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxamide |
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INCHI | InChI=1S/C29H31NO7/c1-30(2)27(32)23-24(17-9-7-6-8-10-17)29(18-11-13-19(34-3)14-12-18)28(33,26(23)31)25-21(36-5)15-20(35-4)16-22(25)37-29/h6-16,23-24,26,31,33H,1-5H3/t23-,24-,26-,28+,29+/m1/s1 |
InChi Key | DAPAQENNNINUPW-IDAMAFBJSA-N |
Canonical SMILES | CN(C)C(=O)C1C(C2(C(C1O)(C3=C(O2)C=C(C=C3OC)OC)O)C4=CC=C(C=C4)OC)C5=CC=CC=C5 |
Isomeric SMILES | CN(C)C(=O)[C@@H]1[C@H]([C@]2([C@@]([C@@H]1O)(C3=C(O2)C=C(C=C3OC)OC)O)C4=CC=C(C=C4)OC)C5=CC=CC=C5 |
PubChem CID | 331783 |
Molecular Weight | 505.57 |
Solubility | Soluble in DMSO and ethanol |
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