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rodatristat , CAS No.1673568-73-4, Inhibitor of L-Tryptophan hydroxylase 1;Inhibitor of L-Tryptophan hydroxylase 2

Item Number
R613265
Grouped product items
SKUSizeAvailabilityPrice Qty
R613265-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$805.90
R613265-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,815.90
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L-Tryptophan hydroxylase 1 Inhibitor L-Tryptophan hydroxylase 2 Inhibitor

Basic Description

SynonymsRodatristat | KAR5417 | KAR-5417 | 1673568-73-4 | Rodatristat [USAN] | RVT-1201/014 | 91D8378G2V | CHEMBL4104957 | UNII-91D8378G2V | Rodatristat (USAN) | (3S)-8-(2-Amino-6-((1R)-1-(5-chloro(1,1'-biphenyl)-2-yl)-2,2,2-trifluoroethoxy)-4-pyrimidinyl)-2,8-diazaspiro(4.5)decane-
Specifications & PurityMoligand™
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of L-Tryptophan hydroxylase 1;Inhibitor of L-Tryptophan hydroxylase 2

Associated Targets(Human)

TPH1 Tclin Tryptophan 5-hydroxylase 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TPH2 Tchem Tryptophan 5-hydroxylase 2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TPH2 Tchem Tryptophan 5-hydroxylase 2 (43 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TPH1 Tclin Tryptophan 5-hydroxylase 1 (286 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Canis familiaris (36305 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name (3S)-8-[2-amino-6-[(1R)-1-(4-chloro-2-phenylphenyl)-2,2,2-trifluoroethoxy]pyrimidin-4-yl]-2,8-diazaspiro[4.5]decane-3-carboxylic acid
INCHI InChI=1S/C27H27ClF3N5O3/c28-17-6-7-18(19(12-17)16-4-2-1-3-5-16)23(27(29,30)31)39-22-13-21(34-25(32)35-22)36-10-8-26(9-11-36)14-20(24(37)38)33-15-26/h1-7,12-13,20,23,33H,8-11,14-15H2,(H,37,38)(H2,32,34,35)/t20-,23+/m0/s1
InChi Key ZNSPHKJFQDEABI-NZQKXSOJSA-N
Canonical SMILES Nc1nc(cc(n1)N1CCC2(CC1)CN[C@@H](C2)C(=O)O)O[C@@H](C(F)(F)F)c1ccc(cc1c1ccccc1)Cl
Isomeric SMILES C1CN(CCC12C[C@H](NC2)C(=O)O)C3=CC(=NC(=N3)N)O[C@H](C4=C(C=C(C=C4)Cl)C5=CC=CC=C5)C(F)(F)F
PubChem CID 117947705

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Related Documents

 SDS

 Specification Sheet

References

1. Sikander A, Rana SV, Prasad KK.  (2009)  Role of serotonin in gastrointestinal motility and irritable bowel syndrome..  Clin Chim Acta,  403  (1-2): (47-55).  [PMID:19361459]
2. Goldberg DR, De Lombaert S, Aiello R, Bourassa P, Barucci N, Zhang Q, Paralkar V, Stein AJ, Holt M, Valentine J et al..  (2017)  Optimization of spirocyclic proline tryptophan hydroxylase-1 inhibitors..  Bioorg Med Chem Lett,  27  (3): (413-419).  [PMID:28041831]
3. Domínguez-Soto Á, Usategui A, Casas-Engel ML, Simón-Fuentes M, Nieto C, Cuevas VD, Vega MA, Luis Pablos J, Corbí ÁL.  (2017)  Serotonin drives the acquisition of a profibrotic and anti-inflammatory gene profile through the 5-HT7R-PKA signaling axis..  Sci Rep,  7  (1): (14761).  [PMID:29116249]

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